DUSP6

Dual specificity phosphatase 6
PDB rendering based on 1hzm.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 1hzm​, 1mkp​
Identifiers
Symbols	DUSP6 ; MKP3; PYST1
External IDs	Template:OMIM5 Template:MGI HomoloGene: 55621
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Dual specificity phosphatase 6, also known as DUSP6, is a human gene.

The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates ERK2, is expressed in a variety of tissues with the highest levels in heart and pancreas, and unlike most other members of this family, is localized in the cytoplasm. Two transcript variants encoding different isoforms have been found for this gene.

Further reading

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. PMID 8125298.
• Muda M, Boschert U, Dickinson R; et al. (1996). "MKP-3, a novel cytosolic protein-tyrosine phosphatase that exemplifies a new class of mitogen-activated protein kinase phosphatase". J. Biol. Chem. 271 (8): 4319–26. PMID 8626780.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Groom LA, Sneddon AA, Alessi DR; et al. (1996). "Differential regulation of the MAP, SAP and RK/p38 kinases by Pyst1, a novel cytosolic dual-specificity phosphatase". EMBO J. 15 (14): 3621–32. PMID 8670865.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Smith A, Price C, Cullen M; et al. (1997). "Chromosomal localization of three human dual specificity phosphatase genes (DUSP4, DUSP6, and DUSP7)". Genomics. 42 (3): 524–7. doi:10.1006/geno.1997.4756. PMID 9205128.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K; et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. PMID 9373149.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Muda M, Theodosiou A, Gillieron C; et al. (1998). "The mitogen-activated protein kinase phosphatase-3 N-terminal noncatalytic region is responsible for tight substrate binding and enzymatic specificity". J. Biol. Chem. 273 (15): 9323–9. PMID 9535927.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Furukawa T, Yatsuoka T, Youssef EM; et al. (1999). "Genomic analysis of DUSP6, a dual specificity MAP kinase phosphatase, in pancreatic cancer". Cytogenet. Cell Genet. 82 (3–4): 156–9. PMID 9858808.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Stewart AE, Dowd S, Keyse SM, McDonald NQ (1999). "Crystal structure of the MAPK phosphatase Pyst1 catalytic domain and implications for regulated activation". Nat. Struct. Biol. 6 (2): 174–81. doi:10.1038/5861. PMID 10048930.CS1 maint: Multiple names: authors list (link)
• Rössig L, Hermann C, Haendeler J; et al. (2002). "Angiotensin II-induced upregulation of MAP kinase phosphatase-3 mRNA levels mediates endothelial cell apoptosis". Basic Res. Cardiol. 97 (1): 1–8. PMID 11998972.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Furukawa T, Sunamura M, Motoi F; et al. (2003). "Potential tumor suppressive pathway involving DUSP6/MKP-3 in pancreatic cancer". Am. J. Pathol. 162 (6): 1807–15. PMID 12759238.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kim HS, Song MC, Kwak IH; et al. (2003). "Constitutive induction of p-Erk1/2 accompanied by reduced activities of protein phosphatases 1 and 2A and MKP3 due to reactive oxygen species during cellular senescence". J. Biol. Chem. 278 (39): 37497–510. doi:10.1074/jbc.M211739200. PMID 12840032.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kim Y, Rice AE, Denu JM (2004). "Intramolecular dephosphorylation of ERK by MKP3". Biochemistry. 42 (51): 15197–207. doi:10.1021/bi035346b. PMID 14690430.CS1 maint: Multiple names: authors list (link)
• Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Karlsson M, Mathers J, Dickinson RJ; et al. (2004). "Both nuclear-cytoplasmic shuttling of the dual specificity phosphatase MKP-3 and its ability to anchor MAP kinase in the cytoplasm are mediated by a conserved nuclear export signal". J. Biol. Chem. 279 (40): 41882–91. doi:10.1074/jbc.M406720200. PMID 15269220.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Marchetti S, Gimond C, Chambard JC; et al. (2005). "Extracellular signal-regulated kinases phosphorylate mitogen-activated protein kinase phosphatase 3/DUSP6 at serines 159 and 197, two sites critical for its proteasomal degradation". Mol. Cell. Biol. 25 (2): 854–64. doi:10.1128/MCB.25.2.854-864.2005. PMID 15632084.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kamata H, Honda S, Maeda S; et al. (2005). "Reactive oxygen species promote TNFalpha-induced death and sustained JNK activation by inhibiting MAP kinase phosphatases". Cell. 120 (5): 649–61. doi:10.1016/j.cell.2004.12.041. PMID 15766528.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Xu S, Furukawa T, Kanai N; et al. (2005). "Abrogation of DUSP6 by hypermethylation in human pancreatic cancer". J. Hum. Genet. 50 (4): 159–67. doi:10.1007/s10038-005-0235-y. PMID 15824892.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Furukawa T, Fujisaki R, Yoshida Y; et al. (2005). "Distinct progression pathways involving the dysfunction of DUSP6/MKP-3 in pancreatic intraepithelial neoplasia and intraductal papillary-mucinous neoplasms of the pancreas". Mod. Pathol. 18 (8): 1034–42. doi:10.1038/modpathol.3800383. PMID 15832194.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)