DYNLT1

Dynein, light chain, Tctex-type 1
Identifiers
Symbols	DYNLT1 ; CW-1; MGC111571; TCTEL1; tctex-1
External IDs	Template:OMIM5 Template:MGI HomoloGene: 4754
Gene ontology Molecular function Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO
RNA expression pattern
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Dynein, light chain, Tctex-type 1, also known as DYNLT1, is a human gene.

Cytoplasmic dynein is the major motor protein complex responsible for minus-end, microtubule-based motile processes. Each dynein complex consists of 2 heavy chains that have ATPase and motor activities, plus a group of accessory polypeptides. TCTEX1 is a dynein light chain involved in cargo binding (Chuang et al., 2005).[supplied by OMIM]

Further reading

• Tete R, de Montgolfier R, Piante M (1971). "[Leiomyoma and leiomyosarcoma of the small intestine. Value of selective angiography]". Journal de médecine de Lyon. 52 (192): 1523-6 passim. PMID 5503857.CS1 maint: Multiple names: authors list (link)
• Watanabe TK, Fujiwara T, Shimizu F; et al. (1996). "Cloning, expression, and mapping of TCTEL1, a putative human homologue of murine Tcte1, to 6q". Cytogenet. Cell Genet. 73 (1–2): 153–6. PMID 8646886.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• King SM, Dillman JF, Benashski SE; et al. (1997). "The mouse t-complex-encoded protein Tctex-1 is a light chain of brain cytoplasmic dynein". J. Biol. Chem. 271 (50): 32281–7. PMID 8943288.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Nagano F, Orita S, Sasaki T; et al. (1998). "Interaction of Doc2 with tctex-1, a light chain of cytoplasmic dynein. Implication in dynein-dependent vesicle transport". J. Biol. Chem. 273 (46): 30065–8. PMID 9804756.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strovel ET, Wu D, Sussman DJ (2000). "Protein phosphatase 2Calpha dephosphorylates axin and activates LEF-1-dependent transcription". J. Biol. Chem. 275 (4): 2399–403. PMID 10644691.CS1 maint: Multiple names: authors list (link)
• Mueller S, Cao X, Welker R, Wimmer E (2002). "Interaction of the poliovirus receptor CD155 with the dynein light chain Tctex-1 and its implication for poliovirus pathogenesis". J. Biol. Chem. 277 (10): 7897–904. doi:10.1074/jbc.M111937200. PMID 11751937.CS1 maint: Multiple names: authors list (link)
• Schwarzer C, Barnikol-Watanabe S, Thinnes FP, Hilschmann N (2002). "Voltage-dependent anion-selective channel (VDAC) interacts with the dynein light chain Tctex1 and the heat-shock protein PBP74". Int. J. Biochem. Cell Biol. 34 (9): 1059–70. PMID 12009301.CS1 maint: Multiple names: authors list (link)
• Nadano D, Nakayama J, Matsuzawa S; et al. (2002). "Human tastin, a proline-rich cytoplasmic protein, associates with the microtubular cytoskeleton". Biochem. J. 364 (Pt 3): 669–77. doi:10.1042/BJ20011836. PMID 12049630.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Machado RD, Rudarakanchana N, Atkinson C; et al. (2004). "Functional interaction between BMPR-II and Tctex-1, a light chain of Dynein, is isoform-specific and disrupted by mutations underlying primary pulmonary hypertension". Hum. Mol. Genet. 12 (24): 3277–86. doi:10.1093/hmg/ddg365. PMID 14583445.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Douglas MW, Diefenbach RJ, Homa FL; et al. (2004). "Herpes simplex virus type 1 capsid protein VP26 interacts with dynein light chains RP3 and Tctex1 and plays a role in retrograde cellular transport". J. Biol. Chem. 279 (27): 28522–30. doi:10.1074/jbc.M311671200. PMID 15117959.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ohka S, Matsuda N, Tohyama K; et al. (2004). "Receptor (CD155)-dependent endocytosis of poliovirus and retrograde axonal transport of the endosome". J. Virol. 78 (13): 7186–98. doi:10.1128/JVI.78.13.7186-7198.2004. PMID 15194795.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• de Wit NJ, Verschuure P, Kappé G; et al. (2005). "Testis-specific human small heat shock protein HSPB9 is a cancer/testis antigen, and potentially interacts with the dynein subunit TCTEL1". Eur. J. Cell Biol. 83 (7): 337–45. PMID 15503857.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Chuang JZ, Yeh TY, Bollati F; et al. (2005). "The dynein light chain Tctex-1 has a dynein-independent role in actin remodeling during neurite outgrowth". Dev. Cell. 9 (1): 75–86. doi:10.1016/j.devcel.2005.04.003. PMID 15992542.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Pfister KK, Fisher EM, Gibbons IR; et al. (2006). "Cytoplasmic dynein nomenclature". J. Cell Biol. 171 (3): 411–3. doi:10.1083/jcb.200508078. PMID 16260502.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Yeh TY, Peretti D, Chuang JZ; et al. (2007). "Regulatory dissociation of Tctex-1 light chain from dynein complex is essential for the apical delivery of rhodopsin". Traffic. 7 (11): 1495–502. doi:10.1111/j.1600-0854.2006.00482.x. PMID 16956385.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)