Diablo homolog

Diablo homolog (Drosophila)
PDB rendering based on 1few.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 1few​, 1g73​
Identifiers
Symbols	DIABLO ; DIABLO-S; FLJ10537; FLJ25049; SMAC; SMAC3
External IDs	Template:OMIM5 Template:MGI HomoloGene: 10532
Gene ontology Molecular function Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Diablo homolog (Drosophila), also known as DIABLO, is a human gene.

This gene encodes an inhibitor of apoptosis protein (IAP)-binding protein. The encoded mitochondrial protein enters the cytosol when cells undergo apoptosis, and it moderates the caspase inhibition of IAPs. Multiple polyadenylation sites have been found for this gene. Several alternatively spliced transcript variants that encode distinct isoforms have been described for this gene but the validity of some transcripts, and their predicted ORFs, has not been determined conclusively.

Further reading

• Shi Y (2001). "A structural view of mitochondria-mediated apoptosis". Nat. Struct. Biol. 8 (5): 394–401. doi:10.1038/87548. PMID 11323712.
• Anguiano-Hernandez YM, Chartier A, Huerta S (2007). "Smac/DIABLO and colon cancer". Anti-cancer agents in medicinal chemistry. 7 (4): 467–73. PMID 17630921.CS1 maint: Multiple names: authors list (link)
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. PMID 8125298.
• Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. PMID 8889548.CS1 maint: Multiple names: authors list (link)
• Hillier LD, Lennon G, Becker M; et al. (1997). "Generation and analysis of 280,000 human expressed sequence tags". Genome Res. 6 (9): 807–28. PMID 8889549.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K; et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. PMID 9373149.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Du C, Fang M, Li Y; et al. (2000). "Smac, a mitochondrial protein that promotes cytochrome c-dependent caspase activation by eliminating IAP inhibition". Cell. 102 (1): 33–42. PMID 10929711.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Verhagen AM, Ekert PG, Pakusch M; et al. (2000). "Identification of DIABLO, a mammalian protein that promotes apoptosis by binding to and antagonizing IAP proteins". Cell. 102 (1): 43–53. PMID 10929712.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Srinivasula SM, Datta P, Fan XJ; et al. (2000). "Molecular determinants of the caspase-promoting activity of Smac/DIABLO and its role in the death receptor pathway". J. Biol. Chem. 275 (46): 36152–7. doi:10.1074/jbc.C000533200. PMID 10950947.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Chai J, Du C, Wu JW; et al. (2000). "Structural and biochemical basis of apoptotic activation by Smac/DIABLO". Nature. 406 (6798): 855–62. doi:10.1038/35022514. PMID 10972280.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Liu Z, Sun C, Olejniczak ET; et al. (2001). "Structural basis for binding of Smac/DIABLO to the XIAP BIR3 domain". Nature. 408 (6815): 1004–8. doi:10.1038/35050006. PMID 11140637.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Wu G, Chai J, Suber TL; et al. (2001). "Structural basis of IAP recognition by Smac/DIABLO". Nature. 408 (6815): 1008–12. doi:10.1038/35050012. PMID 11140638.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Srinivasula SM, Hegde R, Saleh A; et al. (2001). "A conserved XIAP-interaction motif in caspase-9 and Smac/DIABLO regulates caspase activity and apoptosis". Nature. 410 (6824): 112–6. doi:10.1038/35065125. PMID 11242052.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Huang Y, Park YC, Rich RL; et al. (2001). "Structural basis of caspase inhibition by XIAP: differential roles of the linker versus the BIR domain". Cell. 104 (5): 781–90. PMID 11257231.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Roberts DL, Merrison W, MacFarlane M, Cohen GM (2001). "The inhibitor of apoptosis protein-binding domain of Smac is not essential for its proapoptotic activity". J. Cell Biol. 153 (1): 221–8. PMID 11285287.CS1 maint: Multiple names: authors list (link)
• Verhagen AM, Silke J, Ekert PG; et al. (2002). "HtrA2 promotes cell death through its serine protease activity and its ability to antagonize inhibitor of apoptosis proteins". J. Biol. Chem. 277 (1): 445–54. doi:10.1074/jbc.M109891200. PMID 11604410.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Adrain C, Creagh EM, Martin SJ (2002). "Apoptosis-associated release of Smac/DIABLO from mitochondria requires active caspases and is blocked by Bcl-2". EMBO J. 20 (23): 6627–36. doi:10.1093/emboj/20.23.6627. PMID 11726499.CS1 maint: Multiple names: authors list (link)
• Sun XM, Bratton SB, Butterworth M; et al. (2002). "Bcl-2 and Bcl-xL inhibit CD95-mediated apoptosis by preventing mitochondrial release of Smac/DIABLO and subsequent inactivation of X-linked inhibitor-of-apoptosis protein". J. Biol. Chem. 277 (13): 11345–51. doi:10.1074/jbc.M109893200. PMID 11801595.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Vucic D, Deshayes K, Ackerly H; et al. (2002). "SMAC negatively regulates the anti-apoptotic activity of melanoma inhibitor of apoptosis (ML-IAP)". J. Biol. Chem. 277 (14): 12275–9. doi:10.1074/jbc.M112045200. PMID 11801603.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)