EEF1B2

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Eukaryotic translation elongation factor 1 beta 2
PDB rendering based on 1b64.
Available structures
PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB
Identifiers
Symbols EEF1B2 ; EEF1B1; EF1B; EEF1B
External IDs Template:OMIM5 Template:MGI HomoloGene: 1480
Orthologs
Template:GNF Ortholog box
Species Human Mouse
Entrez n/a n/a
Ensembl n/a n/a
UniProt n/a n/a
RefSeq (mRNA) n/a n/a
RefSeq (protein) n/a n/a
Location (UCSC) n/a n/a
PubMed search n/a n/a

Eukaryotic translation elongation factor 1 beta 2, also known as EEF1B2, is a human gene.[1]

This gene encodes a translation elongation factor. The protein is a guanine nucleotide exchange factor involved in the transfer of aminoacylated tRNAs to the ribosome. Alternative splicing results in three transcript variants which differ only in the 5' UTR.[1]

References

  1. ↑ 1.0 1.1 "Entrez Gene: EEF1B2 eukaryotic translation elongation factor 1 beta 2".

Further reading

  • Rasmussen HH, van Damme J, Puype M; et al. (1993). "Microsequences of 145 proteins recorded in the two-dimensional gel protein database of normal human epidermal keratinocytes". Electrophoresis. 13 (12): 960–9. PMID 1286667.
  • Hochstrasser DF, Frutiger S, Paquet N; et al. (1993). "Human liver protein map: a reference database established by microsequencing and gel comparison". Electrophoresis. 13 (12): 992–1001. PMID 1286669.
  • von der Kammer H, Klaudiny J, Zimmer M, Scheit KH (1991). "Human elongation factor 1 beta: cDNA and derived amino acid sequence". Biochem. Biophys. Res. Commun. 177 (1): 312–7. PMID 1710449.
  • Sanders J, Maassen JA, Amons R, Möller W (1991). "Nucleotide sequence of human elongation factor-1 beta cDNA". Nucleic Acids Res. 19 (16): 4551. PMID 1886777.
  • Bec G, Kerjan P, Zha XD, Waller JP (1990). "Valyl-tRNA synthetase from rabbit liver. I. Purification as a heterotypic complex in association with elongation factor 1". J. Biol. Chem. 264 (35): 21131–7. PMID 2556394.
  • Motorin YuA , Wolfson AD, Orlovsky AF, Gladilin KL (1988). "Mammalian valyl-tRNA synthetase forms a complex with the first elongation factor". FEBS Lett. 238 (2): 262–4. PMID 3169261.
  • Pizzuti A, Gennarelli M, Novelli G; et al. (1994). "Human elongation factor EF-1 beta: cloning and characterization of the EF1 beta 5a gene and assignment of EF-1 beta isoforms to chromosomes 2,5,15 and X.". Biochem. Biophys. Res. Commun. 197 (1): 154–62. PMID 8250921.
  • Chen CJ, Traugh JA (1996). "Expression of recombinant elongation factor 1 beta from rabbit in Escherichia coli. Phosphorylation by casein kinase II". Biochim. Biophys. Acta. 1264 (3): 303–11. PMID 8547318.
  • Béhar G, Coleclough C, Houlgatte R; et al. (1996). "Human lymphocyte cDNA ordered library analyzed by 2D gel electrophoresis. 3. Analysis of individual clones". Appl. Theor. Electrophor. 5 (2): 99–105. PMID 8573604.
  • Sanders J, Brandsma M, Janssen GM; et al. (1996). "Immunofluorescence studies of human fibroblasts demonstrate the presence of the complex of elongation factor-1 beta gamma delta in the endoplasmic reticulum". J. Cell. Sci. 109 ( Pt 5): 1113–7. PMID 8743958.
  • Sheu GT, Traugh JA (1998). "Recombinant subunits of mammalian elongation factor 1 expressed in Escherichia coli. Subunit interactions, elongation activity, and phosphorylation by protein kinase CKII". J. Biol. Chem. 272 (52): 33290–7. PMID 9407120.
  • Sheu GT, Traugh JA (1999). "A structural model for elongation factor 1 (EF-1) and phosphorylation by protein kinase CKII". Mol. Cell. Biochem. 191 (1–2): 181–6. PMID 10094407.
  • Pérez JM, Siegal G, Kriek J; et al. (1999). "The solution structure of the guanine nucleotide exchange domain of human elongation factor 1beta reveals a striking resemblance to that of EF-Ts from Escherichia coli". Structure. 7 (2): 217–26. PMID 10368288.
  • Chambers DM, Rouleau GA, Abbott CM (2001). "Comparative genomic analysis of genes encoding translation elongation factor 1B(alpha) in human and mouse shows EEF1B1 to be a recent retrotransposition event". Genomics. 77 (3): 145–8. doi:10.1006/geno.2001.6626. PMID 11597139.
  • Sang Lee J, Gyu Park S, Park H; et al. (2002). "Interaction network of human aminoacyl-tRNA synthetases and subunits of elongation factor 1 complex". Biochem. Biophys. Res. Commun. 291 (1): 158–64. doi:10.1006/bbrc.2002.6398. PMID 11829477.
  • Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
  • Cans C, Passer BJ, Shalak V; et al. (2004). "Translationally controlled tumor protein acts as a guanine nucleotide dissociation inhibitor on the translation elongation factor eEF1A". Proc. Natl. Acad. Sci. U.S.A. 100 (24): 13892–7. doi:10.1073/pnas.2335950100. PMID 14623968.
  • Shu H, Chen S, Bi Q; et al. (2004). "Identification of phosphoproteins and their phosphorylation sites in the WEHI-231 B lymphoma cell line". Mol. Cell Proteomics. 3 (3): 279–86. doi:10.1074/mcp.D300003-MCP200. PMID 14729942.
  • Beausoleil SA, Jedrychowski M, Schwartz D; et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMID 15302935.
  • Ito T, Marintchev A, Wagner G (2005). "Solution structure of human initiation factor eIF2alpha reveals homology to the elongation factor eEF1B". Structure. 12 (9): 1693–704. doi:10.1016/j.str.2004.07.010. PMID 15341733.

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