EIF4A1

Eukaryotic translation initiation factor 4A, isoform 1
PDB rendering based on 2g9n.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 2g9n​
Identifiers
Symbols	EIF4A1 ; DDX2A; EIF-4A; EIF4A
External IDs	Template:OMIM5 Template:MGI HomoloGene: 68182
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Biological process Template:GNF GO
RNA expression pattern
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Eukaryotic translation initiation factor 4A, isoform 1, also known as EIF4A1, is a human gene.

Further reading

• Reddy NS, Roth WW, Bragg PW, Wahba AJ (1989). "Isolation and mapping of a gene for protein synthesis initiation factor 4A and its expression during differentiation of murine erythroleukemia cells". Gene. 70 (2): 231–43. PMID 3215517.CS1 maint: Multiple names: authors list (link)
• Kim NS, Kato T, Abe N, Kato S (1993). "Nucleotide sequence of human cDNA encoding eukaryotic initiation factor 4AI". Nucleic Acids Res. 21 (8): 2012. PMID 8493113.CS1 maint: Multiple names: authors list (link)
• Kukimoto I, Watanabe S, Taniguchi K; et al. (1997). "Characterization of the cloned promoter of the human initiation factor 4AI gene". Biochem. Biophys. Res. Commun. 233 (3): 844–7. doi:10.1006/bbrc.1997.6555. PMID 9168945.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Imataka H, Sonenberg N (1997). "Human eukaryotic translation initiation factor 4G (eIF4G) possesses two separate and independent binding sites for eIF4A". Mol. Cell. Biol. 17 (12): 6940–7. PMID 9372926.
• Gradi A, Imataka H, Svitkin YV; et al. (1998). "A novel functional human eukaryotic translation initiation factor 4G". Mol. Cell. Biol. 18 (1): 334–42. PMID 9418880.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Craig AW, Haghighat A, Yu AT, Sonenberg N (1998). "Interaction of polyadenylate-binding protein with the eIF4G homologue PAIP enhances translation". Nature. 392 (6675): 520–3. doi:10.1038/33198. PMID 9548260.CS1 maint: Multiple names: authors list (link)
• Jones E, Quinn CM, See CG; et al. (1998). "The linked human elongation initiation factor 4A1 (EIF4A1) and CD68 genes map to chromosome 17p13". Genomics. 53 (2): 248–50. doi:10.1006/geno.1998.5515. PMID 9790779.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Henis-Korenblit S, Strumpf NL, Goldstaub D, Kimchi A (2000). "A novel form of DAP5 protein accumulates in apoptotic cells as a result of caspase cleavage and internal ribosome entry site-mediated translation". Mol. Cell. Biol. 20 (2): 496–506. PMID 10611228.CS1 maint: Multiple names: authors list (link)
• Quinn CM, Wiles AP, El-Shanawany T; et al. (2000). "The human eukaryotic initiation factor 4AI gene (EIF4A1) contains multiple regulatory elements that direct high-level reporter gene expression in mammalian cell lines". Genomics. 62 (3): 468–76. doi:10.1006/geno.1999.6031. PMID 10644445.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Cuesta R, Xi Q, Schneider RJ (2000). "Adenovirus-specific translation by displacement of kinase Mnk1 from cap-initiation complex eIF4F". EMBO J. 19 (13): 3465–74. doi:10.1093/emboj/19.13.3465. PMID 10880459.CS1 maint: Multiple names: authors list (link)
• Mendell JT, Medghalchi SM, Lake RG; et al. (2000). "Novel Upf2p orthologues suggest a functional link between translation initiation and nonsense surveillance complexes". Mol. Cell. Biol. 20 (23): 8944–57. PMID 11073994.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Li W, Belsham GJ, Proud CG (2001). "Eukaryotic initiation factors 4A (eIF4A) and 4G (eIF4G) mutually interact in a 1:1 ratio in vivo". J. Biol. Chem. 276 (31): 29111–5. doi:10.1074/jbc.C100284200. PMID 11408474.CS1 maint: Multiple names: authors list (link)
• Du MX, Johnson RB, Sun XL; et al. (2002). "Comparative characterization of two DEAD-box RNA helicases in superfamily II: human translation-initiation factor 4A and hepatitis C virus non-structural protein 3 (NS3) helicase". Biochem. J. 363 (Pt 1): 147–55. PMID 11903057.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Bohnsack MT, Regener K, Schwappach B; et al. (2003). "Exp5 exports eEF1A via tRNA from nuclei and synergizes with other transport pathways to confine translation to the cytoplasm". EMBO J. 21 (22): 6205–15. PMID 12426392.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Yang HS, Cho MH, Zakowicz H; et al. (2004). "A novel function of the MA-3 domains in transformation and translation suppressor Pdcd4 is essential for its binding to eukaryotic translation initiation factor 4A". Mol. Cell. Biol. 24 (9): 3894–906. PMID 15082783.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Mingot JM, Bohnsack MT, Jäkle U, Görlich D (2005). "Exportin 7 defines a novel general nuclear export pathway". EMBO J. 23 (16): 3227–36. doi:10.1038/sj.emboj.7600338. PMID 15282546.CS1 maint: Multiple names: authors list (link)
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Hinton TM, Coldwell MJ, Carpenter GA; et al. (2007). "Functional analysis of individual binding activities of the scaffold protein eIF4G". J. Biol. Chem. 282 (3): 1695–708. doi:10.1074/jbc.M602780200. PMID 17130132.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ewing RM, Chu P, Elisma F; et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3: 89. doi:10.1038/msb4100134. PMID 17353931.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)