EIF4A3

Eukaryotic translation initiation factor 4A, isoform 3
PDB rendering based on 2hxy.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 2hxy​, 2hyi​, 2j0q​, 2j0s​, 2j0u​
Identifiers
Symbols	EIF4A3 ; DDX48; KIAA0111; MGC10862; NUK-34; eIF4AIII; hNMP265
External IDs	Template:OMIM5 Template:MGI HomoloGene: 5602
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Eukaryotic translation initiation factor 4A, isoform 3, also known as EIF4A3, is a human gene.

This gene encodes a member of the DEAD box protein family. DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure, such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. The protein encoded by this gene is a nuclear matrix protein. Its amino acid sequence is highly similar to the amino acid sequences of the translation initiation factors eIF4AI and eIF4AII, two other members of the DEAD box protein family.

Further reading

• Nagase T, Miyajima N, Tanaka A; et al. (1995). "Prediction of the coding sequences of unidentified human genes. III. The coding sequences of 40 new genes (KIAA0081-KIAA0120) deduced by analysis of cDNA clones from human cell line KG-1". DNA Res. 2 (1): 37–43. PMID 7788527.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Li Q, Imataka H, Morino S; et al. (1999). "Eukaryotic translation initiation factor 4AIII (eIF4AIII) is functionally distinct from eIF4AI and eIF4AII". Mol. Cell. Biol. 19 (11): 7336–46. PMID 10523622.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Holzmann K, Gerner C, Pöltl A; et al. (2000). "A human common nuclear matrix protein homologous to eukaryotic translation initiation factor 4A". Biochem. Biophys. Res. Commun. 267 (1): 339–44. doi:10.1006/bbrc.1999.1973. PMID 10623621.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Jurica MS, Licklider LJ, Gygi SR; et al. (2002). "Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis". RNA. 8 (4): 426–39. PMID 11991638.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Lee S, Baek M, Yang H; et al. (2002). "Identification of genes differentially expressed between gastric cancers and normal gastric mucosa with cDNA microarrays". Cancer Lett. 184 (2): 197–206. PMID 12127692.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Chan CC, Dostie J, Diem MD; et al. (2004). "eIF4A3 is a novel component of the exon junction complex". RNA. 10 (2): 200–9. PMID 14730019.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Palacios IM, Gatfield D, St Johnston D, Izaurralde E (2004). "An eIF4AIII-containing complex required for mRNA localization and nonsense-mediated mRNA decay". Nature. 427 (6976): 753–7. doi:10.1038/nature02351. PMID 14973490.CS1 maint: Multiple names: authors list (link)
• Ferraiuolo MA, Lee CS, Ler LW; et al. (2004). "A nuclear translation-like factor eIF4AIII is recruited to the mRNA during splicing and functions in nonsense-mediated decay". Proc. Natl. Acad. Sci. U.S.A. 101 (12): 4118–23. doi:10.1073/pnas.0400933101. PMID 15024115.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Shibuya T, Tange TØ, Sonenberg N, Moore MJ (2004). "eIF4AIII binds spliced mRNA in the exon junction complex and is essential for nonsense-mediated decay". Nat. Struct. Mol. Biol. 11 (4): 346–51. doi:10.1038/nsmb750. PMID 15034551.CS1 maint: Multiple names: authors list (link)
• Jin J, Smith FD, Stark C; et al. (2004). "Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization". Curr. Biol. 14 (16): 1436–50. doi:10.1016/j.cub.2004.07.051. PMID 15324660.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Andersen JS, Lam YW, Leung AK; et al. (2005). "Nucleolar proteome dynamics". Nature. 433 (7021): 77–83. doi:10.1038/nature03207. PMID 15635413.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Xia Q, Kong XT, Zhang GA; et al. (2005). "Proteomics-based identification of DEAD-box protein 48 as a novel autoantigen, a prospective serum marker for pancreatic cancer". Biochem. Biophys. Res. Commun. 330 (2): 526–32. doi:10.1016/j.bbrc.2005.02.181. PMID 15796914.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ballut L, Marchadier B, Baguet A; et al. (2005). "The exon junction core complex is locked onto RNA by inhibition of eIF4AIII ATPase activity". Nat. Struct. Mol. Biol. 12 (10): 861–9. doi:10.1038/nsmb990. PMID 16170325.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Rual JF, Venkatesan K, Hao T; et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gehring NH, Kunz JB, Neu-Yilik G; et al. (2005). "Exon-junction complex components specify distinct routes of nonsense-mediated mRNA decay with differential cofactor requirements". Mol. Cell. 20 (1): 65–75. doi:10.1016/j.molcel.2005.08.012. PMID 16209946.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Andersen CB, Ballut L, Johansen JS; et al. (2006). "Structure of the exon junction core complex with a trapped DEAD-box ATPase bound to RNA". Science. 313 (5795): 1968–72. doi:10.1126/science.1131981. PMID 16931718.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• You KT, Li LS, Kim NG; et al. (2007). "Selective translational repression of truncated proteins from frameshift mutation-derived mRNAs in tumors". PLoS Biol. 5 (5): e109. doi:10.1371/journal.pbio.0050109. PMID 17456004.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Zhang Z, Krainer AR (2007). "Splicing remodels messenger ribonucleoprotein architecture via eIF4A3-dependent and -independent recruitment of exon junction complex components". Proc. Natl. Acad. Sci. U.S.A. 104 (28): 11574–9. doi:10.1073/pnas.0704946104. PMID 17606899.