EPS15

Epidermal growth factor receptor pathway substrate 15
PDB rendering based on 1c07.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 1c07​, 1eh2​, 1f8h​, 1ff1​, 1qjt​
Identifiers
Symbols	EPS15 ; AF-1P; AF1P; MLLT5
External IDs	Template:OMIM5 Template:MGI HomoloGene: 81627
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Epidermal growth factor receptor pathway substrate 15, also known as EPS15, is a human gene.

This gene encodes a protein that is part of the EGFR pathway. The protein is present at clatherin-coated pits and is involved in receptor-mediated endocytosis of EGF. Notably, this gene is rearranged with the HRX/ALL/MLL gene in acute myelogeneous leukemias. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized.

References

• Schumacher C, Knudsen BS, Ohuchi T; et al. (1995). "The SH3 domain of Crk binds specifically to a conserved proline-rich motif in Eps15 and Eps15R". J. Biol. Chem. 270 (25): 15341–7. PMID 7797522.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Bernard OA, Mauchauffe M, Mecucci C; et al. (1994). "A novel gene, AF-1p, fused to HRX in t(1;11)(p32;q23), is not related to AF-4, AF-9 nor ENL". Oncogene. 9 (4): 1039–45. PMID 8134107.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Wong WT, Kraus MH, Carlomagno F; et al. (1994). "The human eps15 gene, encoding a tyrosine kinase substrate, is conserved in evolution and maps to 1p31-p32". Oncogene. 9 (6): 1591–7. PMID 8183552.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Andersson B, Wentland MA, Ricafrente JY; et al. (1996). "A "double adaptor" method for improved shotgun library construction". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Benmerah A, Bégue B, Dautry-Varsat A, Cerf-Bensussan N (1996). "The ear of alpha-adaptin interacts with the COOH-terminal domain of the Eps 15 protein". J. Biol. Chem. 271 (20): 12111–6. PMID 8662627.CS1 maint: Multiple names: authors list (link)
• Matsuda M, Ota S, Tanimura R; et al. (1996). "Interaction between the amino-terminal SH3 domain of CRK and its natural target proteins". J. Biol. Chem. 271 (24): 14468–72. PMID 8662907.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• van Delft S, Schumacher C, Hage W; et al. (1997). "Association and colocalization of Eps15 with adaptor protein-2 and clathrin". J. Cell Biol. 136 (4): 811–21. PMID 9049247.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Yu W, Andersson B, Worley KC; et al. (1997). "Large-scale concatenation cDNA sequencing". Genome Res. 7 (4): 353–8. PMID 9110174.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Tebar F, Confalonieri S, Carter RE; et al. (1997). "Eps15 is constitutively oligomerized due to homophilic interaction of its coiled-coil region". J. Biol. Chem. 272 (24): 15413–8. PMID 9182572.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Salcini AE, Confalonieri S, Doria M; et al. (1997). "Binding specificity and in vivo targets of the EH domain, a novel protein-protein interaction module". Genes Dev. 11 (17): 2239–49. PMID 9303539.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Cupers P, ter Haar E, Boll W, Kirchhausen T (1998). "Parallel dimers and anti-parallel tetramers formed by epidermal growth factor receptor pathway substrate clone 15". J. Biol. Chem. 272 (52): 33430–4. PMID 9407139.CS1 maint: Multiple names: authors list (link)
• Haffner C, Takei K, Chen H; et al. (1998). "Synaptojanin 1: localization on coated endocytic intermediates in nerve terminals and interaction of its 170 kDa isoform with Eps15". FEBS Lett. 419 (2–3): 175–80. PMID 9428629.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Benmerah A, Lamaze C, Bègue B; et al. (1998). "AP-2/Eps15 interaction is required for receptor-mediated endocytosis". J. Cell Biol. 140 (5): 1055–62. PMID 9490719.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• de Beer T, Carter RE, Lobel-Rice KE; et al. (1998). "Structure and Asn-Pro-Phe binding pocket of the Eps15 homology domain". Science. 281 (5381): 1357–60. PMID 9721102.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Chen H, Fre S, Slepnev VI; et al. (1998). "Epsin is an EH-domain-binding protein implicated in clathrin-mediated endocytosis". Nature. 394 (6695): 793–7. doi:10.1038/29555. PMID 9723620.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Lewin DA, Sheff D, Ooi CE; et al. (1998). "Cloning, expression, and localization of a novel gamma-adaptin-like molecule". FEBS Lett. 435 (2–3): 263–8. PMID 9762922.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Sengar AS, Wang W, Bishay J; et al. (1999). "The EH and SH3 domain Ese proteins regulate endocytosis by linking to dynamin and Eps15". EMBO J. 18 (5): 1159–71. doi:10.1093/emboj/18.5.1159. PMID 10064583.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Poupon V, Bègue B, Gagnon J; et al. (1999). "Molecular cloning and characterization of MT-ACT48, a novel mitochondrial acyl-CoA thioesterase". J. Biol. Chem. 274 (27): 19188–94. PMID 10383425.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Nakashima S, Morinaka K, Koyama S; et al. (1999). "Small G protein Ral and its downstream molecules regulate endocytosis of EGF and insulin receptors". EMBO J. 18 (13): 3629–42. doi:10.1093/emboj/18.13.3629. PMID 10393179.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Stephens DJ, Banting G (1999). "Direct interaction of the trans-Golgi network membrane protein, TGN38, with the F-actin binding protein, neurabin". J. Biol. Chem. 274 (42): 30080–6. PMID 10514494.