EZH2

Enhancer of zeste homolog 2 (Drosophila)
Identifiers
Symbols	EZH2 ; EZH1; ENX-1; MGC9169
External IDs	Template:OMIM5 Template:MGI HomoloGene: 37926
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Enhancer of zeste homolog 2 (Drosophila), also known as EZH2, is a human gene.

This gene encodes a member of the Polycomb-group (PcG) family. PcG family members form multimeric protein complexes, which are involved in maintaining the transcriptional repressive state of genes over successive cell generations. This protein associates with the embryonic ectoderm development protein, the VAV1 oncoprotein, and the X-linked nuclear protein. This protein may play a role in the hematopoietic and central nervous systems. Two transcript variants encoding distinct isoforms have been identified for this gene.

Further reading

• Zeidler M, Kleer CG (2007). "The Polycomb group protein Enhancer of Zeste 2: its links to DNA repair and breast cancer". J. Mol. Histol. 37 (5–7): 219–23. doi:10.1007/s10735-006-9042-9. PMID 16855786.
• De Haan G, Gerrits A (2007). "Epigenetic control of hematopoietic stem cell aging the case of Ezh2". Ann. N. Y. Acad. Sci. 1106: 233–9. doi:10.1196/annals.1392.008. PMID 17332078.
• Hobert O, Jallal B, Ullrich A (1996). "Interaction of Vav with ENX-1, a putative transcriptional regulator of homeobox gene expression". Mol. Cell. Biol. 16 (6): 3066–73. PMID 8649418.CS1 maint: Multiple names: authors list (link)
• Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. PMID 8889548.CS1 maint: Multiple names: authors list (link)
• Abel KJ, Brody LC, Valdes JM; et al. (1997). "Characterization of EZH1, a human homolog of Drosophila Enhancer of zeste near BRCA1". Genomics. 37 (2): 161–71. doi:10.1006/geno.1996.0537. PMID 8921387.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Chen H, Rossier C, Antonarakis SE (1997). "Cloning of a human homolog of the Drosophila enhancer of zeste gene (EZH2) that maps to chromosome 21q22.2". Genomics. 38 (1): 30–7. doi:10.1006/geno.1996.0588. PMID 8954776.CS1 maint: Multiple names: authors list (link)
• Laible G, Wolf A, Dorn R; et al. (1997). "Mammalian homologues of the Polycomb-group gene Enhancer of zeste mediate gene silencing in Drosophila heterochromatin and at S. cerevisiae telomeres". EMBO J. 16 (11): 3219–32. doi:10.1093/emboj/16.11.3219. PMID 9214638.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Cardoso C, Timsit S, Villard L; et al. (1998). "Specific interaction between the XNP/ATR-X gene product and the SET domain of the human EZH2 protein". Hum. Mol. Genet. 7 (4): 679–84. PMID 9499421.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• van Lohuizen M, Tijms M, Voncken JW; et al. (1998). "Interaction of mouse polycomb-group (Pc-G) proteins Enx1 and Enx2 with Eed: indication for separate Pc-G complexes". Mol. Cell. Biol. 18 (6): 3572–9. PMID 9584197.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Sewalt RG, van der Vlag J, Gunster MJ; et al. (1998). "Characterization of interactions between the mammalian polycomb-group proteins Enx1/EZH2 and EED suggests the existence of different mammalian polycomb-group protein complexes". Mol. Cell. Biol. 18 (6): 3586–95. PMID 9584199.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Denisenko O, Shnyreva M, Suzuki H, Bomsztyk K (1998). "Point mutations in the WD40 domain of Eed block its interaction with Ezh2". Mol. Cell. Biol. 18 (10): 5634–42. PMID 9742080.CS1 maint: Multiple names: authors list (link)
• van der Vlag J, Otte AP (1999). "Transcriptional repression mediated by the human polycomb-group protein EED involves histone deacetylation". Nat. Genet. 23 (4): 474–8. doi:10.1038/70602. PMID 10581039.
• Cardoso C, Mignon C, Hetet G; et al. (2000). "The human EZH2 gene: genomic organisation and revised mapping in 7q35 within the critical region for malignant myeloid disorders". Eur. J. Hum. Genet. 8 (3): 174–80. doi:10.1038/sj.ejhg.5200439. PMID 10780782.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Raaphorst FM, Otte AP, van Kemenade FJ; et al. (2001). "Distinct BMI-1 and EZH2 expression patterns in thymocytes and mature T cells suggest a role for Polycomb genes in human T cell differentiation". J. Immunol. 166 (10): 5925–34. PMID 11342607.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• O'Connell S, Wang L, Robert S; et al. (2001). "Polycomblike PHD fingers mediate conserved interaction with enhancer of zeste protein". J. Biol. Chem. 276 (46): 43065–73. doi:10.1074/jbc.M104294200. PMID 11571280.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Varambally S, Dhanasekaran SM, Zhou M; et al. (2002). "The polycomb group protein EZH2 is involved in progression of prostate cancer". Nature. 419 (6907): 624–9. doi:10.1038/nature01075. PMID 12374981.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Scherer SW, Cheung J, MacDonald JR; et al. (2003). "Human chromosome 7: DNA sequence and biology". Science. 300 (5620): 767–72. doi:10.1126/science.1083423. PMID 12690205.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Hillier LW, Fulton RS, Fulton LA; et al. (2003). "The DNA sequence of human chromosome 7". Nature. 424 (6945): 157–64. doi:10.1038/nature01782. PMID 12853948.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kleer CG, Cao Q, Varambally S; et al. (2003). "EZH2 is a marker of aggressive breast cancer and promotes neoplastic transformation of breast epithelial cells". Proc. Natl. Acad. Sci. U.S.A. 100 (20): 11606–11. doi:10.1073/pnas.1933744100. PMID 14500907.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)