Endothelin converting enzyme 1

Endothelin converting enzyme 1
Identifiers
Symbols	ECE1 ; ECE
External IDs	Template:OMIM5 Template:MGI HomoloGene: 1068
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO
RNA expression pattern
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Endothelin converting enzyme 1, also known as ECE1, is a human gene.

Endothelin-converting enzyme-1 is involved in the proteolytic processing of endothelin-1 (EDN1; MIM 131240), -2 (EDN2; MIM 131241), and -3 (EDN3; MIM 131242) to biologically active peptides.[supplied by OMIM]

Further reading

• Yorimitsu K, Moroi K, Inagaki N; et al. (1995). "Cloning and sequencing of a human endothelin converting enzyme in renal adenocarcinoma (ACHN) cells producing endothelin-2". Biochem. Biophys. Res. Commun. 208 (2): 721–7. PMID 7695628.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Schmidt M, Kröger B, Jacob E; et al. (1995). "Molecular characterization of human and bovine endothelin converting enzyme (ECE-1)". FEBS Lett. 356 (2–3): 238–43. PMID 7805846.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Shimada K, Matsushita Y, Wakabayashi K; et al. (1995). "Cloning and functional expression of human endothelin-converting enzyme cDNA". Biochem. Biophys. Res. Commun. 207 (2): 807–12. doi:10.1006/bbrc.1995.1258. PMID 7864876.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Valdenaire O, Rohrbacher E, Mattei MG (1996). "Organization of the gene encoding the human endothelin-converting enzyme (ECE-1)". J. Biol. Chem. 270 (50): 29794–8. PMID 8530372.CS1 maint: Multiple names: authors list (link)
• Matsuoka R, Sawamura T, Yamada K; et al. (1996). "Human endothelin converting enzyme gene (ECE1) mapped to chromosomal region 1p36.1". Cytogenet. Cell Genet. 72 (4): 322–4. PMID 8641140.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Orzechowski HD, Richter CM, Funke-Kaiser H; et al. (1997). "Evidence of alternative promoters directing isoform-specific expression of human endothelin-converting enzyme-1 mRNA in cultured endothelial cells". J. Mol. Med. 75 (7): 512–21. PMID 9253714.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Schweizer A, Valdenaire O, Nelböck P; et al. (1998). "Human endothelin-converting enzyme (ECE-1): three isoforms with distinct subcellular localizations". Biochem. J. 328 ( Pt 3): 871–7. PMID 9396733.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kido T, Sawamura T, Masaki T (1998). "The processing pathway of endothelin-1 production". J. Cardiovasc. Pharmacol. 31 Suppl 1: S13–5. PMID 9595387.CS1 maint: Multiple names: authors list (link)
• Hofstra RM, Valdenaire O, Arch E; et al. (1999). "A loss-of-function mutation in the endothelin-converting enzyme 1 (ECE-1) associated with Hirschsprung disease, cardiac defects, and autonomic dysfunction". Am. J. Hum. Genet. 64 (1): 304–8. PMID 9915973.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Lee S, Lin M, Mele A; et al. (1999). "Proteolytic processing of big endothelin-3 by the kell blood group protein". Blood. 94 (4): 1440–50. PMID 10438732.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Valdenaire O, Lepailleur-Enouf D, Egidy G; et al. (1999). "A fourth isoform of endothelin-converting enzyme (ECE-1) is generated from an additional promoter molecular cloning and characterization". Eur. J. Biochem. 264 (2): 341–9. PMID 10491078.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Fahnoe DC, Johnson GD, Herman SB, Ahn K (2000). "Disulfide bonds in big ET-1 are essential for the specific cleavage at the Trp(21)-Val(22) bond by soluble endothelin converting enzyme-1 from baculovirus/insect cells". Arch. Biochem. Biophys. 373 (2): 385–93. doi:10.1006/abbi.1999.1586. PMID 10620363.CS1 maint: Multiple names: authors list (link)
• López-Ongil S, Senchak V, Saura M; et al. (2000). "Superoxide regulation of endothelin-converting enzyme". J. Biol. Chem. 275 (34): 26423–7. doi:10.1074/jbc.M000767200. PMID 10833511.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Hachiya A, Kobayashi T, Takema Y, Imokawa G (2002). "Biochemical characterization of endothelin-converting enzyme-1alpha in cultured skin-derived cells and its postulated role in the stimulation of melanogenesis in human epidermis". J. Biol. Chem. 277 (7): 5395–403. doi:10.1074/jbc.M105874200. PMID 11723113.CS1 maint: Multiple names: authors list (link)
• Inguimbert N, Coric P, Poras H; et al. (2002). "Toward an optimal joint recognition of the S1' subsites of endothelin converting enzyme-1 (ECE-1), angiotensin converting enzyme (ACE), and neutral endopeptidase (NEP)". J. Med. Chem. 45 (7): 1477–86. PMID 11906289.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• MacLeod KJ, Husain RD, Gage DA, Ahn K (2003). "Constitutive phosphorylation of human endothelin-converting enzyme-1 isoforms". J. Biol. Chem. 277 (48): 46355–63. doi:10.1074/jbc.M207972200. PMID 12244060.CS1 maint: Multiple names: authors list (link)
• Muller L, Barret A, Etienne E; et al. (2003). "Heterodimerization of endothelin-converting enzyme-1 isoforms regulates the subcellular distribution of this metalloprotease". J. Biol. Chem. 278 (1): 545–55. doi:10.1074/jbc.M208949200. PMID 12393864.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Eckman EA, Watson M, Marlow L; et al. (2003). "Alzheimer's disease beta-amyloid peptide is increased in mice deficient in endothelin-converting enzyme". J. Biol. Chem. 278 (4): 2081–4. doi:10.1074/jbc.C200642200. PMID 12464614.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Masatsugu K, Itoh H, Chun TH; et al. (2003). "Shear stress attenuates endothelin and endothelin-converting enzyme expression through oxidative stress". Regul. Pept. 111 (1–3): 13–9. PMID 12609744.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)