Erythropoietin receptor

Erythropoietin receptor
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 1cn4​, 1eba​, 1ebp​, 1eer​, 1ern​
Identifiers
Symbols	EPOR ; MGC138358
External IDs	Template:OMIM5 Template:MGI HomoloGene: 95
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO
RNA expression pattern
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

The erythropoietin receptor is a 66 kDa peptide and is a member of the cytokine receptor family. The receptor is tyrosine phosphorylated upon binding by erythropoietin and associates with and activates the tyrosine kinase, JAK2, which activates different intracellular pathways including: Ras/MAP kinase, phosphatidylinositol 3-kinase and STAT transcription factors. The stimulated erythropoietin receptor appears to have a role in erythroid cell survival. Defects in the erythropoietin receptor may produce erythroleukemia and familial erythrocytosis.

Further reading

• Zhu Y, D'Andrea AD (1999). "The molecular physiology of erythropoietin and the erythropoietin receptor". Curr. Opin. Hematol. 1 (2): 113–8. PMID 9371269.
• Lacombe C, Mayeux P (1998). "Biology of erythropoietin". Haematologica. 83 (8): 724–32. PMID 9793257.
• Bonifacino JS (2002). "Quality control of receptor-kinase signaling complexes". Dev. Cell. 2 (1): 1–2. PMID 11782306.
• Takeshita A, Shinjo K, Naito K; et al. (2003). "Erythropoietin receptor in myelodysplastic syndrome and leukemia". Leuk. Lymphoma. 43 (2): 261–4. PMID 11999556.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kralovics R, Skoda RC (2005). "Molecular pathogenesis of Philadelphia chromosome negative myeloproliferative disorders". Blood Rev. 19 (1): 1–13. doi:10.1016/j.blre.2004.02.002. PMID 15572213.
• Madeddu P, Emanueli C (2007). "Switching on reparative angiogenesis: essential role of the vascular erythropoietin receptor". Circ. Res. 100 (5): 599–601. doi:10.1161/01.RES.0000261610.11754.b1. PMID 17363704.

External links

• Erythropoietin+Receptors at the US National Library of Medicine Medical Subject Headings (MeSH)