FBLIM1

Filamin binding LIM protein 1
Identifiers
Symbols	FBLIM1 ; CAL; DKFZp434G171; FBLP-1; FBLP1; RP11-169K16.5
External IDs	Template:OMIM5 Template:MGI HomoloGene: 56774
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Biological process Template:GNF GO Template:GNF GO
RNA expression pattern
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Filamin binding LIM protein 1, also known as FBLIM1, is a human gene.

This gene encodes a protein with an N-terminal filamin-binding domain, a central proline-rich domain, and, multiple C-terminal LIM domains. This protein localizes at cell junctions and may link cell adhesion structures to the actin cytoskeleton. This protein may be involved in the assembly and stabilization of actin-filaments and likely plays a role in modulating cell adhesion, cell morphology and cell motility. This protein also localizes to the nucleus and may affect cardiomyocyte differentiation after binding with the CSX/NKX2-5 transcription factor. Alternative splicing results in multiple transcript variants encoding different isoforms.

Further reading

• Wu C (2005). "Migfilin and its binding partners: from cell biology to human diseases". J. Cell. Sci. 118 (Pt 4): 659–64. doi:10.1242/jcs.01639. PMID 15701922.
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Takafuta T, Saeki M, Fujimoto TT; et al. (2003). "A new member of the LIM protein family binds to filamin B and localizes at stress fibers". J. Biol. Chem. 278 (14): 12175–81. doi:10.1074/jbc.M209339200. PMID 12496242.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Tu Y, Wu S, Shi X; et al. (2003). "Migfilin and Mig-2 link focal adhesions to filamin and the actin cytoskeleton and function in cell shape modulation". Cell. 113 (1): 37–47. PMID 12679033.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Akazawa H, Kudoh S, Mochizuki N; et al. (2004). "A novel LIM protein Cal promotes cardiac differentiation by association with CSX/NKX2-5". J. Cell Biol. 164 (3): 395–405. doi:10.1083/jcb.200309159. PMID 14757752.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Brandenberger R, Wei H, Zhang S; et al. (2005). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation". Nat. Biotechnol. 22 (6): 707–16. doi:10.1038/nbt971. PMID 15146197.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gkretsi V, Zhang Y, Tu Y; et al. (2005). "Physical and functional association of migfilin with cell-cell adhesions". J. Cell. Sci. 118 (Pt 4): 697–710. doi:10.1242/jcs.01638. PMID 15671069.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Rual JF, Venkatesan K, Hao T; et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Oh JH, Yang JO, Hahn Y; et al. (2006). "Transcriptome analysis of human gastric cancer". Mamm. Genome. 16 (12): 942–54. doi:10.1007/s00335-005-0075-2. PMID 16341674.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Zhang Y, Tu Y, Gkretsi V, Wu C (2006). "Migfilin interacts with vasodilator-stimulated phosphoprotein (VASP) and regulates VASP localization to cell-matrix adhesions and migration". J. Biol. Chem. 281 (18): 12397–407. doi:10.1074/jbc.M512107200. PMID 16531412.CS1 maint: Multiple names: authors list (link)
• Gregory SG, Barlow KF, McLay KE; et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. doi:10.1038/nature04727. PMID 16710414.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Papachristou DJ, Gkretsi V, Tu Y; et al. (2007). "Increased cytoplasmic level of migfilin is associated with higher grades of human leiomyosarcoma". Histopathology. 51 (4): 499–508. doi:10.1111/j.1365-2559.2007.02791.x. PMID 17711449.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)