FBXW7

F-box and WD repeat domain containing 7
PDB rendering based on 2ovp.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 2ovp​, 2ovq​, 2ovr​
Identifiers
Symbols	FBXW7 ; AGO; CDC4; DKFZp686F23254; FBW7; FBX30; FBXW6; SEL-10; SEL10
External IDs	Template:OMIM5 Template:MGI HomoloGene: 69520
Gene ontology Molecular function Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO
RNA expression pattern
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

F-box and WD repeat domain containing 7, also known as FBXW7, is a human gene.

This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene was previously referred to as FBX30, and belongs to the Fbws class; in addition to an F-box, this protein contains 7 tandem WD40 repeats. This protein binds directly to cyclin E and probably targets cyclin E for ubiquitin-mediated degradation. Mutations in this gene are detected in ovarian and breast cancer cell lines, implicating the gene's potential role in the pathogenesis of human cancers. Three transcript variants encoding three different isoforms have been found for this gene.

Further reading

• Robertson NG, Khetarpal U, Gutiérrez-Espeleta GA; et al. (1995). "Isolation of novel and known genes from a human fetal cochlear cDNA library using subtractive hybridization and differential screening". Genomics. 23 (1): 42–50. doi:10.1006/geno.1994.1457. PMID 7829101.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. PMID 8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K; et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. PMID 9373149.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Winston JT, Koepp DM, Zhu C; et al. (1999). "A family of mammalian F-box proteins". Curr. Biol. 9 (20): 1180–2. doi:10.1016/S0960-9822(00)80021-4. PMID 10531037.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gupta-Rossi N, Le Bail O, Gonen H; et al. (2001). "Functional interaction between SEL-10, an F-box protein, and the nuclear form of activated Notch1 receptor". J. Biol. Chem. 276 (37): 34371–8. doi:10.1074/jbc.M101343200. PMID 11425854.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Oberg C, Li J, Pauley A; et al. (2001). "The Notch intracellular domain is ubiquitinated and negatively regulated by the mammalian Sel-10 homolog". J. Biol. Chem. 276 (38): 35847–53. doi:10.1074/jbc.M103992200. PMID 11461910.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Koepp DM, Schaefer LK, Ye X; et al. (2001). "Phosphorylation-dependent ubiquitination of cyclin E by the SCFFbw7 ubiquitin ligase". Science. 294 (5540): 173–7. doi:10.1126/science.1065203. PMID 11533444.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Moberg KH, Bell DW, Wahrer DC; et al. (2001). "Archipelago regulates Cyclin E levels in Drosophila and is mutated in human cancer cell lines". Nature. 413 (6853): 311–6. doi:10.1038/35095068. PMID 11565033.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strohmaier H, Spruck CH, Kaiser P; et al. (2001). "Human F-box protein hCdc4 targets cyclin E for proteolysis and is mutated in a breast cancer cell line". Nature. 413 (6853): 316–22. doi:10.1038/35095076. PMID 11565034.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Wu G, Lyapina S, Das I; et al. (2001). "SEL-10 is an inhibitor of notch signaling that targets notch for ubiquitin-mediated protein degradation". Mol. Cell. Biol. 21 (21): 7403–15. doi:10.1128/MCB.21.21.7403-7415.2001. PMID 11585921.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Spruck CH, Strohmaier H, Sangfelt O; et al. (2002). "hCDC4 gene mutations in endometrial cancer". Cancer Res. 62 (16): 4535–9. PMID 12183400.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Li J, Pauley AM, Myers RL; et al. (2002). "SEL-10 interacts with presenilin 1, facilitates its ubiquitination, and alters A-beta peptide production". J. Neurochem. 82 (6): 1540–8. PMID 12354302.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Staropoli JF, McDermott C, Martinat C; et al. (2003). "Parkin is a component of an SCF-like ubiquitin ligase complex and protects postmitotic neurons from kainate excitotoxicity". Neuron. 37 (5): 735–49. PMID 12628165.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Calhoun ES, Jones JB, Ashfaq R; et al. (2003). "BRAF and FBXW7 (CDC4, FBW7, AGO, SEL10) mutations in distinct subsets of pancreatic cancer: potential therapeutic targets". Am. J. Pathol. 163 (4): 1255–60. PMID 14507635.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Welcker M, Singer J, Loeb KR; et al. (2003). "Multisite phosphorylation by Cdk2 and GSK3 controls cyclin E degradation". Mol. Cell. 12 (2): 381–92. PMID 14536078.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Busino L, Donzelli M, Chiesa M; et al. (2003). "Degradation of Cdc25A by beta-TrCP during S phase and in response to DNA damage". Nature. 426 (6962): 87–91. doi:10.1038/nature02082. PMID 14603323.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Cassia R, Moreno-Bueno G, Rodríguez-Perales S; et al. (2004). "Cyclin E gene (CCNE) amplification and hCDC4 mutations in endometrial carcinoma". J. Pathol. 201 (4): 589–95. doi:10.1002/path.1474. PMID 14648662.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Nateri AS, Riera-Sans L, Da Costa C, Behrens A (2004). "The ubiquitin ligase SCFFbw7 antagonizes apoptotic JNK signaling". Science. 303 (5662): 1374–8. doi:10.1126/science.1092880. PMID 14739463.CS1 maint: Multiple names: authors list (link)