FGR (gene)

Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog
Identifiers
Symbols	FGR ; FLJ43153; MGC75096; SRC2; c-fgr; c-src2; p55c-fgr; p58c-fgr
External IDs	Template:OMIM5 Template:MGI HomoloGene: 3842
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog, also known as FGR, is a human gene.

This gene is a member of the Src family of protein tyrosine kinases (PTKs). The encoded protein contains N-terminal sites for myristylation and palmitylation, a PTK domain, and SH2 and SH3 domains which are involved in mediating protein-protein interactions with phosphotyrosine-containing and proline-rich motifs, respectively. The protein localizes to plasma membrane ruffles, and functions as a negative regulator of cell migration and adhesion triggered by the beta-2 integrin signal transduction pathway. Infection with Epstein-Barr virus results in the overexpression of this gene. Multiple alternatively spliced variants, encoding the same protein, have been identified.

Further reading

• Patel M, Faulkner L, Katz DR, Brickell PM (1991). "The c-fgr proto-oncogene: expression in Epstein-Barr-virus-infected B lymphocytes and in cells of the myelomonocytic and granulocytic lineages". Pathobiology. 59 (4): 289–92. PMID 1652975.CS1 maint: Multiple names: authors list (link)
• Resh MD (1994). "Myristylation and palmitylation of Src family members: the fats of the matter". Cell. 76 (3): 411–3. PMID 8313462.
• Lowell CA, Berton G (1999). "Integrin signal transduction in myeloid leukocytes". J. Leukoc. Biol. 65 (3): 313–20. PMID 10080533.
• Snapper SB, Rosen FS (1999). "The Wiskott-Aldrich syndrome protein (WASP): roles in signaling and cytoskeletal organization". Annu. Rev. Immunol. 17: 905–29. doi:10.1146/annurev.immunol.17.1.905. PMID 10358777.
• Tatosyan AG, Mizenina OA (2000). "Kinases of the Src family: structure and functions". Biochemistry Mosc. 65 (1): 49–58. PMID 10702640.
• Patel MS, Mankoo BS, Brickell PM (1993). "A polymorphic microsatellite repeat is located close to the promoter region of the c-fgr proto-oncogene (FGR) at chromosome 1p36.2-p36.1". Hum. Mol. Genet. 1 (1): 65. PMID 1339476.CS1 maint: Multiple names: authors list (link)
• Link DC, Gutkind SJ, Robbins KC, Ley TJ (1992). "Characterization of the 5' untranslated region of the human c-fgr gene and identification of the major myelomonocytic c-fgr promoter". Oncogene. 7 (5): 877–84. PMID 1373875.CS1 maint: Multiple names: authors list (link)
• Patel M, Leevers SJ, Brickell PM (1990). "Structure of the complete human c-fgr proto-oncogene and identification of multiple transcriptional start sites". Oncogene. 5 (2): 201–6. PMID 1690869.CS1 maint: Multiple names: authors list (link)
• Biondi A, Paganin C, Rossi V; et al. (1991). "Expression of lineage-restricted protein tyrosine kinase genes in human natural killer cells". Eur. J. Immunol. 21 (3): 843–6. PMID 1826268.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gutkind JS, Link DC, Katamine S; et al. (1991). "A novel c-fgr exon utilized in Epstein-Barr virus-infected B lymphocytes but not in normal monocytes". Mol. Cell. Biol. 11 (3): 1500–7. PMID 1847500.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Patel M, Leevers SJ, Brickell PM (1990). "Regulation of c-fgr proto-oncogene expression in Epstein-Barr virus infected B-cell lines". Int. J. Cancer. 45 (2): 342–6. PMID 2154410.CS1 maint: Multiple names: authors list (link)
• Parker RC, Mardon G, Lebo RV; et al. (1985). "Isolation of duplicated human c-src genes located on chromosomes 1 and 20". Mol. Cell. Biol. 5 (4): 831–8. PMID 2581127.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Brickell PM, Patel M (1989). "Structure and expression of c-fgr protooncogene mRNA in Epstein-Barr virus converted cell lines". Br. J. Cancer. 58 (6): 704–9. PMID 2852026.
• Tronick SR, Popescu NC, Cheah MS; et al. (1985). "Isolation and chromosomal localization of the human fgr protooncogene, a distinct member of the tyrosine kinase gene family". Proc. Natl. Acad. Sci. U.S.A. 82 (19): 6595–9. PMID 2995972.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Cheah MS, Ley TJ, Tronick SR, Robbins KC (1986). "fgr proto-oncogene mRNA induced in B lymphocytes by Epstein-Barr virus infection". Nature. 319 (6050): 238–40. doi:10.1038/319238a0. PMID 3003578.CS1 maint: Multiple names: authors list (link)
• Nishizawa M, Semba K, Yoshida MC; et al. (1987). "Structure, expression, and chromosomal location of the human c-fgr gene". Mol. Cell. Biol. 6 (2): 511–7. PMID 3023853.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Katamine S, Notario V, Rao CD; et al. (1988). "Primary structure of the human fgr proto-oncogene product p55c-fgr". Mol. Cell. Biol. 8 (1): 259–66. PMID 3275868.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Inoue K, Ikawa S, Semba K; et al. (1988). "Isolation and sequencing of cDNA clones homologous to the v-fgr oncogene from a human B lymphocyte cell line, IM-9". Oncogene. 1 (3): 301–4. PMID 3330776.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Nishizawa M, Semba K, Yamamoto T, Toyoshima K (1985). "Human c-f gr gene does not contain coding sequence for actin-like protein". Jpn. J. Cancer Res. 76 (3): 155–9. PMID 3922831.CS1 maint: Multiple names: authors list (link)