FIS1

Fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae)
PDB rendering based on 1iyg.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 1iyg​, 1nzn​, 1pc2​
Identifiers
Symbols	FIS1 ; CGI-135; TTC11
External IDs	Template:OMIM5 Template:MGI HomoloGene: 41099
Gene ontology Molecular function Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae), also known as FIS1, is a human gene.

The balance between fission and fusion regulates the morphology of mitochondria. TTC11 is a component of a mitochondrial complex that promotes mitochondrial fission (James et al., 2003).[supplied by OMIM]

Further reading

• Lai CH, Chou CY, Ch'ang LY; et al. (2000). "Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics". Genome Res. 10 (5): 703–13. PMID 10810093.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• James DI, Parone PA, Mattenberger Y, Martinou JC (2003). "hFis1, a novel component of the mammalian mitochondrial fission machinery". J. Biol. Chem. 278 (38): 36373–9. doi:10.1074/jbc.M303758200. PMID 12783892.CS1 maint: Multiple names: authors list (link)
• Hillier LW, Fulton RS, Fulton LA; et al. (2003). "The DNA sequence of human chromosome 7". Nature. 424 (6945): 157–64. doi:10.1038/nature01782. PMID 12853948.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Yoon Y, Krueger EW, Oswald BJ, McNiven MA (2003). "The mitochondrial protein hFis1 regulates mitochondrial fission in mammalian cells through an interaction with the dynamin-like protein DLP1". Mol. Cell. Biol. 23 (15): 5409–20. PMID 12861026.CS1 maint: Multiple names: authors list (link)
• Kikuchi M, Hatano N, Yokota S; et al. (2004). "Proteomic analysis of rat liver peroxisome: presence of peroxisome-specific isozyme of Lon protease". J. Biol. Chem. 279 (1): 421–8. doi:10.1074/jbc.M305623200. PMID 14561759.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Suzuki M, Jeong SY, Karbowski M; et al. (2003). "The solution structure of human mitochondria fission protein Fis1 reveals a novel TPR-like helix bundle". J. Mol. Biol. 334 (3): 445–58. PMID 14623186.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Dohm JA, Lee SJ, Hardwick JM; et al. (2004). "Cytosolic domain of the human mitochondrial fission protein fis1 adopts a TPR fold". Proteins. 54 (1): 153–6. doi:10.1002/prot.10524. PMID 14705031.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Stojanovski D, Koutsopoulos OS, Okamoto K, Ryan MT (2004). "Levels of human Fis1 at the mitochondrial outer membrane regulate mitochondrial morphology". J. Cell. Sci. 117 (Pt 7): 1201–10. doi:10.1242/jcs.01058. PMID 14996942.CS1 maint: Multiple names: authors list (link)
• Frieden M, James D, Castelbou C; et al. (2004). "Ca(2+) homeostasis during mitochondrial fragmentation and perinuclear clustering induced by hFis1". J. Biol. Chem. 279 (21): 22704–14. doi:10.1074/jbc.M312366200. PMID 15024001.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Lee YJ, Jeong SY, Karbowski M; et al. (2005). "Roles of the mammalian mitochondrial fission and fusion mediators Fis1, Drp1, and Opa1 in apoptosis". Mol. Biol. Cell. 15 (11): 5001–11. doi:10.1091/mbc.E04-04-0294. PMID 15356267.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kong D, Xu L, Yu Y; et al. (2005). "Regulation of Ca2+-induced permeability transition by Bcl-2 is antagonized by Drpl and hFis1". Mol. Cell. Biochem. 272 (1–2): 187–99. PMID 16010987.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Koch A, Yoon Y, Bonekamp NA; et al. (2006). "A role for Fis1 in both mitochondrial and peroxisomal fission in mammalian cells". Mol. Biol. Cell. 16 (11): 5077–86. doi:10.1091/mbc.E05-02-0159. PMID 16107562.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Yu T, Fox RJ, Burwell LS, Yoon Y (2006). "Regulation of mitochondrial fission and apoptosis by the mitochondrial outer membrane protein hFis1". J. Cell. Sci. 118 (Pt 18): 4141–51. doi:10.1242/jcs.02537. PMID 16118244.CS1 maint: Multiple names: authors list (link)
• Yoon YS, Yoon DS, Lim IK; et al. (2006). "Formation of elongated giant mitochondria in DFO-induced cellular senescence: involvement of enhanced fusion process through modulation of Fis1". J. Cell. Physiol. 209 (2): 468–80. doi:10.1002/jcp.20753. PMID 16883569.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Alirol E, James D, Huber D; et al. (2007). "The mitochondrial fission protein hFis1 requires the endoplasmic reticulum gateway to induce apoptosis". Mol. Biol. Cell. 17 (11): 4593–605. doi:10.1091/mbc.E06-05-0377. PMID 16914522.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kobayashi S, Tanaka A, Fujiki Y (2007). "Fis1, DLP1, and Pex11p coordinately regulate peroxisome morphogenesis". Exp. Cell Res. 313 (8): 1675–86. doi:10.1016/j.yexcr.2007.02.028. PMID 17408615.CS1 maint: Multiple names: authors list (link)
• Lee S, Jeong SY, Lim WC; et al. (2007). "Mitochondrial fission and fusion mediators, hFis1 and OPA1, modulate cellular senescence". J. Biol. Chem. 282 (31): 22977–83. doi:10.1074/jbc.M700679200. PMID 17545159.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)