FNTB

Farnesyltransferase, CAAX box, beta
PDB rendering based on 1d8d.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 1d8d​, 1d8e​, 1fpp​, 1ft1​, 1ft2​, 1jcq​, 1jcr​, 1jcs​, 1kzo​, 1kzp​, 1ld7​, 1ld8​, 1mzc​, 1n94​, 1n95​, 1n9a​, 1ni1​, 1nl4​, 1o1r​, 1o1s​, 1o1t​, 1o5m​, 1qbq​, 1s63​, 1sa4​, 1sa5​, 1tn6​, 1tn7​, 1tn8​, 1x81​, 2bed​, 2f0y​, 2h6f​, 2h6g​, 2h6h​, 2h6i​, 2iej​
Identifiers
Symbols	FNTB ; FPTB; MGC31935
External IDs	Template:OMIM5 Template:MGI HomoloGene: 1535
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Farnesyltransferase, CAAX box, beta, also known as FNTB, is a human gene.

Further reading

• Manne V, Roberts D, Tobin A; et al. (1990). "Identification and preliminary characterization of protein-cysteine farnesyltransferase". Proc. Natl. Acad. Sci. U.S.A. 87 (19): 7541–5. PMID 2217184.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. PMID 8125298.
• Sinensky M, Fantle K, Trujillo M; et al. (1994). "The processing pathway of prelamin A.". J. Cell. Sci. 107 ( Pt 1): 61–7. PMID 8175923.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Andres DA, Milatovich A, Ozçelik T; et al. (1994). "cDNA cloning of the two subunits of human CAAX farnesyltransferase and chromosomal mapping of FNTA and FNTB loci and related sequences". Genomics. 18 (1): 105–12. doi:10.1006/geno.1993.1432. PMID 8276393.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Omer CA, Kral AM, Diehl RE; et al. (1993). "Characterization of recombinant human farnesyl-protein transferase: cloning, expression, farnesyl diphosphate binding, and functional homology with yeast prenyl-protein transferases". Biochemistry. 32 (19): 5167–76. PMID 8494894.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Wang T, Danielson PD, Li BY; et al. (1996). "The p21(RAS) farnesyltransferase alpha subunit in TGF-beta and activin signaling". Science. 271 (5252): 1120–2. PMID 8599089.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Nantais DE, Schwemmle M, Stickney JT; et al. (1996). "Prenylation of an interferon-gamma-induced GTP-binding protein: the human guanylate binding protein, huGBP1". J. Leukoc. Biol. 60 (3): 423–31. PMID 8830800.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Goalstone ML, Draznin B (1996). "Effect of insulin on farnesyltransferase activity in 3T3-L1 adipocytes". J. Biol. Chem. 271 (44): 27585–9. PMID 8910345.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K; et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. PMID 9373149.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Long SB, Casey PJ, Beese LS (1998). "Cocrystal structure of protein farnesyltransferase complexed with a farnesyl diphosphate substrate". Biochemistry. 37 (27): 9612–8. doi:10.1021/bi980708e. PMID 9657673.CS1 maint: Multiple names: authors list (link)
• Prakash B, Praefcke GJ, Renault L; et al. (2000). "Structure of human guanylate-binding protein 1 representing a unique class of GTP-binding proteins". Nature. 403 (6769): 567–71. doi:10.1038/35000617. PMID 10676968.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Zeng Q, Si X, Horstmann H; et al. (2000). "Prenylation-dependent association of protein-tyrosine phosphatases PRL-1, -2, and -3 with the plasma membrane and the early endosome". J. Biol. Chem. 275 (28): 21444–52. doi:10.1074/jbc.M000453200. PMID 10747914.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ashar HR, James L, Gray K; et al. (2000). "Farnesyl transferase inhibitors block the farnesylation of CENP-E and CENP-F and alter the association of CENP-E with the microtubules". J. Biol. Chem. 275 (39): 30451–7. doi:10.1074/jbc.M003469200. PMID 10852915.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Guenzi E, Töpolt K, Cornali E; et al. (2001). "The helical domain of GBP-1 mediates the inhibition of endothelial cell proliferation by inflammatory cytokines". EMBO J. 20 (20): 5568–77. doi:10.1093/emboj/20.20.5568. PMID 11598000.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Long SB, Hancock PJ, Kral AM; et al. (2001). "The crystal structure of human protein farnesyltransferase reveals the basis for inhibition by CaaX tetrapeptides and their mimetics". Proc. Natl. Acad. Sci. U.S.A. 98 (23): 12948–53. doi:10.1073/pnas.241407898. PMID 11687658.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Lobell RB, Omer CA, Abrams MT; et al. (2002). "Evaluation of farnesyl:protein transferase and geranylgeranyl:protein transferase inhibitor combinations in preclinical models". Cancer Res. 61 (24): 8758–68. PMID 11751396.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Bell IM, Gallicchio SN, Abrams M; et al. (2002). "3-Aminopyrrolidinone farnesyltransferase inhibitors: design of macrocyclic compounds with improved pharmacokinetics and excellent cell potency". J. Med. Chem. 45 (12): 2388–409. PMID 12036349.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Long SB, Casey PJ, Beese LS (2002). "Reaction path of protein farnesyltransferase at atomic resolution". Nature. 419 (6907): 645–50. doi:10.1038/nature00986. PMID 12374986.CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• deSolms SJ, Ciccarone TM, MacTough SC; et al. (2003). "Dual protein farnesyltransferase-geranylgeranyltransferase-I inhibitors as potential cancer chemotherapeutic agents". J. Med. Chem. 46 (14): 2973–84. doi:10.1021/jm020587n. PMID 12825937.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)