FYB

FYN binding protein (FYB-120/130)
PDB rendering based on 1ri9.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 1ri9​, 2gtj​, 2gto​
Identifiers
Symbols	FYB ; ADAP; PRO0823; SLAP-130
External IDs	Template:OMIM5 Template:MGI HomoloGene: 22664
Gene ontology Molecular function Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

FYN binding protein (FYB-120/130), also known as FYB, is a human gene.

Further reading

• da Silva AJ, Janssen O, Rudd CE (1993). "T cell receptor zeta/CD3-p59fyn(T)-associated p120/130 binds to the SH2 domain of p59fyn(T)". J. Exp. Med. 178 (6): 2107–13. PMID 7504057.CS1 maint: Multiple names: authors list (link)
• Musci MA, Hendricks-Taylor LR, Motto DG; et al. (1997). "Molecular cloning of SLAP-130, an SLP-76-associated substrate of the T cell antigen receptor-stimulated protein tyrosine kinases". J. Biol. Chem. 272 (18): 11674–7. PMID 9115214.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• da Silva AJ, Li Z, de Vera C; et al. (1997). "Cloning of a novel T-cell protein FYB that binds FYN and SH2-domain-containing leukocyte protein 76 and modulates interleukin 2 production". Proc. Natl. Acad. Sci. U.S.A. 94 (14): 7493–8. PMID 9207119.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Liu J, Kang H, Raab M; et al. (1998). "FYB (FYN binding protein) serves as a binding partner for lymphoid protein and FYN kinase substrate SKAP55 and a SKAP55-related protein in T cells". Proc. Natl. Acad. Sci. U.S.A. 95 (15): 8779–84. PMID 9671755.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Marie-Cardine A, Hendricks-Taylor LR, Boerth NJ; et al. (1998). "Molecular interaction between the Fyn-associated protein SKAP55 and the SLP-76-associated phosphoprotein SLAP-130". J. Biol. Chem. 273 (40): 25789–95. PMID 9748251.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Marie-Cardine A, Verhagen AM, Eckerskorn C, Schraven B (1998). "SKAP-HOM, a novel adaptor protein homologous to the FYN-associated protein SKAP55". FEBS Lett. 435 (1): 55–60. PMID 9755858.CS1 maint: Multiple names: authors list (link)
• Veale M, Raab M, Li Z; et al. (1999). "Novel isoform of lymphoid adaptor FYN-T-binding protein (FYB-130) interacts with SLP-76 and up-regulates interleukin 2 production". J. Biol. Chem. 274 (40): 28427–35. PMID 10497204.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Hamid N, Gustavsson A, Andersson K; et al. (1999). "YopH dephosphorylates Cas and Fyn-binding protein in macrophages". Microb. Pathog. 27 (4): 231–42. doi:10.1006/mpat.1999.0301. PMID 10502464.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Geng L, Raab M, Rudd CE (1999). "Cutting edge: SLP-76 cooperativity with FYB/FYN-T in the Up-regulation of TCR-driven IL-2 transcription requires SLP-76 binding to FYB at Tyr595 and Tyr651". J. Immunol. 163 (11): 5753–7. PMID 10570256.CS1 maint: Multiple names: authors list (link)
• Krause M, Sechi AS, Konradt M; et al. (2000). "Fyn-binding protein (Fyb)/SLP-76-associated protein (SLAP), Ena/vasodilator-stimulated phosphoprotein (VASP) proteins and the Arp2/3 complex link T cell receptor (TCR) signaling to the actin cytoskeleton". J. Cell Biol. 149 (1): 181–94. PMID 10747096.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kang H, Freund C, Duke-Cohan JS; et al. (2000). "SH3 domain recognition of a proline-independent tyrosine-based RKxxYxxY motif in immune cell adaptor SKAP55". EMBO J. 19 (12): 2889–99. doi:10.1093/emboj/19.12.2889. PMID 10856234.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Asazuma N, Wilde JI, Berlanga O; et al. (2000). "Interaction of linker for activation of T cells with multiple adapter proteins in platelets activated by the glycoprotein VI-selective ligand, convulxin". J. Biol. Chem. 275 (43): 33427–34. doi:10.1074/jbc.M001439200. PMID 10942756.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Li C, Iosef C, Jia CY; et al. (2003). "Dual functional roles for the X-linked lymphoproliferative syndrome gene product SAP/SH2D1A in signaling through the signaling lymphocyte activation molecule (SLAM) family of immune receptors". J. Biol. Chem. 278 (6): 3852–9. doi:10.1074/jbc.M206649200. PMID 12458214.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Brill LM, Salomon AR, Ficarro SB; et al. (2004). "Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry". Anal. Chem. 76 (10): 2763–72. doi:10.1021/ac035352d. PMID 15144186.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Heuer K, Arbuzova A, Strauss H; et al. (2005). "The helically extended SH3 domain of the T cell adaptor protein ADAP is a novel lipid interaction domain". J. Mol. Biol. 348 (4): 1025–35. doi:10.1016/j.jmb.2005.02.069. PMID 15843031.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Huang Y, Norton DD, Precht P; et al. (2005). "Deficiency of ADAP/Fyb/SLAP-130 destabilizes SKAP55 in Jurkat T cells". J. Biol. Chem. 280 (25): 23576–83. doi:10.1074/jbc.M413201200. PMID 15849195.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Koga S, Yogo K, Yoshikawa K; et al. (2005). "Physical and functional association of c-Src and adhesion and degranulation promoting adaptor protein (ADAP) in osteoclastogenesis in vitro". J. Biol. Chem. 280 (36): 31564–71. doi:10.1074/jbc.M502703200. PMID 16020549.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Duke-Cohan JS, Kang H, Liu H, Rudd CE (2006). "Regulation and function of SKAP-55 non-canonical motif binding to the SH3c domain of adhesion and degranulation-promoting adaptor protein". J. Biol. Chem. 281 (19): 13743–50. doi:10.1074/jbc.M508774200. PMID 16461356.CS1 maint: Multiple names: authors list (link)