GAB1

GRB2-associated binding protein 1
Identifiers
Symbols	GAB1 ;
External IDs	Template:OMIM5 Template:MGI HomoloGene: 1542
Gene ontology Molecular function Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

GRB2-associated binding protein 1, also known as GAB1, is a human gene.

The protein encoded by this gene is a member of the IRS1-like multisubstrate docking protein family. The encoded protein is an important mediator of branching tubulogenesis and plays a central role in cellular growth response, transformation and apoptosis. Two transcript variants encoding different isoforms have been found for this gene.

Further reading

• Holgado-Madruga M, Emlet DR, Moscatello DK; et al. (1996). "A Grb2-associated docking protein in EGF- and insulin-receptor signalling". Nature. 379 (6565): 560–4. doi:10.1038/379560a0. PMID 8596638.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Fixman ED, Holgado-Madruga M, Nguyen L; et al. (1997). "Efficient cellular transformation by the Met oncoprotein requires a functional Grb2 binding site and correlates with phosphorylation of the Grb2-associated proteins, Cbl and Gab1". J. Biol. Chem. 272 (32): 20167–72. PMID 9242692.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Nguyen L, Holgado-Madruga M, Maroun C; et al. (1997). "Association of the multisubstrate docking protein Gab1 with the hepatocyte growth factor receptor requires a functional Grb2 binding site involving tyrosine 1356". J. Biol. Chem. 272 (33): 20811–9. PMID 9252406.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Holgado-Madruga M, Moscatello DK, Emlet DR; et al. (1997). "Grb2-associated binder-1 mediates phosphatidylinositol 3-kinase activation and the promotion of cell survival by nerve growth factor". Proc. Natl. Acad. Sci. U.S.A. 94 (23): 12419–24. PMID 9356464.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Rocchi S, Tartare-Deckert S, Murdaca J; et al. (1998). "Determination of Gab1 (Grb2-associated binder-1) interaction with insulin receptor-signaling molecules". Mol. Endocrinol. 12 (7): 914–23. PMID 9658397.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Qiu M, Hua S, Agrawal M; et al. (1999). "Molecular cloning and expression of human grap-2, a novel leukocyte-specific SH2- and SH3-containing adaptor-like protein that binds to gab-1". Biochem. Biophys. Res. Commun. 253 (2): 443–7. doi:10.1006/bbrc.1998.9795. PMID 9878555.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Lehr S, Kotzka J, Herkner A; et al. (1999). "Identification of tyrosine phosphorylation sites in human Gab-1 protein by EGF receptor kinase in vitro". Biochemistry. 38 (1): 151–9. doi:10.1021/bi9818265. PMID 9890893.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Maroun CR, Holgado-Madruga M, Royal I; et al. (1999). "The Gab1 PH domain is required for localization of Gab1 at sites of cell-cell contact and epithelial morphogenesis downstream from the met receptor tyrosine kinase". Mol. Cell. Biol. 19 (3): 1784–99. PMID 10022866.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Nishida K, Yoshida Y, Itoh M; et al. (1999). "Gab-family adapter proteins act downstream of cytokine and growth factor receptors and T- and B-cell antigen receptors". Blood. 93 (6): 1809–16. PMID 10068651.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gual P, Giordano S, Williams TA; et al. (2000). "Sustained recruitment of phospholipase C-gamma to Gab1 is required for HGF-induced branching tubulogenesis". Oncogene. 19 (12): 1509–18. doi:10.1038/sj.onc.1203514. PMID 10734310.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Braun L, Ghebrehiwet B, Cossart P (2000). "gC1q-R/p32, a C1q-binding protein, is a receptor for the InlB invasion protein of Listeria monocytogenes". EMBO J. 19 (7): 1458–66. doi:10.1093/emboj/19.7.1458. PMID 10747014.CS1 maint: Multiple names: authors list (link)
• Sakkab D, Lewitzky M, Posern G; et al. (2000). "Signaling of hepatocyte growth factor/scatter factor (HGF) to the small GTPase Rap1 via the large docking protein Gab1 and the adapter protein CRKL". J. Biol. Chem. 275 (15): 10772–8. PMID 10753869.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Lehr S, Kotzka J, Herkner A; et al. (2000). "Identification of major tyrosine phosphorylation sites in the human insulin receptor substrate Gab-1 by insulin receptor kinase in vitro". Biochemistry. 39 (35): 10898–907. PMID 10978177.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Sachs M, Brohmann H, Zechner D; et al. (2000). "Essential role of Gab1 for signaling by the c-Met receptor in vivo". J. Cell Biol. 150 (6): 1375–84. PMID 10995442.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Yart A, Laffargue M, Mayeux P; et al. (2001). "A critical role for phosphoinositide 3-kinase upstream of Gab1 and SHP2 in the activation of ras and mitogen-activated protein kinases by epidermal growth factor". J. Biol. Chem. 276 (12): 8856–64. doi:10.1074/jbc.M006966200. PMID 11134009.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ingham RJ, Santos L, Dang-Lawson M; et al. (2001). "The Gab1 docking protein links the b cell antigen receptor to the phosphatidylinositol 3-kinase/Akt signaling pathway and to the SHP2 tyrosine phosphatase". J. Biol. Chem. 276 (15): 12257–65. doi:10.1074/jbc.M010590200. PMID 11278704.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Lewitzky M, Kardinal C, Gehring NH; et al. (2001). "The C-terminal SH3 domain of the adapter protein Grb2 binds with high affinity to sequences in Gab1 and SLP-76 which lack the SH3-typical P-x-x-P core motif". Oncogene. 20 (9): 1052–62. doi:10.1038/sj.onc.1204202. PMID 11314042.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Cunnick JM, Mei L, Doupnik CA, Wu J (2001). "Phosphotyrosines 627 and 659 of Gab1 constitute a bisphosphoryl tyrosine-based activation motif (BTAM) conferring binding and activation of SHP2". J. Biol. Chem. 276 (26): 24380–7. doi:10.1074/jbc.M010275200. PMID 11323411.CS1 maint: Multiple names: authors list (link)
• Kurokawa K, Iwashita T, Murakami H; et al. (2001). "Identification of SNT/FRS2 docking site on RET receptor tyrosine kinase and its role for signal transduction". Oncogene. 20 (16): 1929–38. doi:10.1038/sj.onc.1204290. PMID 11360177.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kameda H, Risinger JI, Han BB; et al. (2001). "Identification of epidermal growth factor receptor- Grb2-associated binder-1-SHP-2 complex formation and its functional loss during neoplastic cell progression". Cell Growth Differ. 12 (6): 307–18. PMID 11432805.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)