GALNT3

UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 3 (GalNAc-T3)
Identifiers
Symbols	GALNT3 ; DKFZp686C10199; GalNAc-T3; HFTC; HHS; MGC61909
External IDs	Template:OMIM5 Template:MGI HomoloGene: 55827
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Template:GNF GO Biological process Template:GNF GO
RNA expression pattern
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 3 (GalNAc-T3), also known as GALNT3, is a human gene.

This gene encodes UDP-GalNAc transferase 3, a member of the GalNAc-transferases family. This family transfers an N-acetyl galactosamine to the hydroxyl group of a serine or threonine residue in the first step of O-linked oligosaccharide biosynthesis. Individual GalNAc-transferases have distinct activities and initiation of O-glycosylation is regulated by a repertoire of GalNAc-transferases. The protein encoded by this gene is highly homologous to other family members, however the enzymes have different substrate specificities.

Further reading

• Bennett EP, Hassan H, Clausen H (1996). "cDNA cloning and expression of a novel human UDP-N-acetyl-alpha-D-galactosamine. Polypeptide N-acetylgalactosaminyltransferase, GalNAc-t3". J. Biol. Chem. 271 (29): 17006–12. PMID 8663203.CS1 maint: Multiple names: authors list (link)
• Wandall HH, Hassan H, Mirgorodskaya E; et al. (1997). "Substrate specificities of three members of the human UDP-N-acetyl-alpha-D-galactosamine:Polypeptide N-acetylgalactosaminyltransferase family, GalNAc-T1, -T2, and -T3". J. Biol. Chem. 272 (38): 23503–14. PMID 9295285.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Röttger S, White J, Wandall HH; et al. (1998). "Localization of three human polypeptide GalNAc-transferases in HeLa cells suggests initiation of O-linked glycosylation throughout the Golgi apparatus". J. Cell. Sci. 111 ( Pt 1): 45–60. PMID 9394011.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Bennett EP, Weghuis DO, Merkx G; et al. (1998). "Genomic organization and chromosomal localization of three members of the UDP-N-acetylgalactosamine: polypeptide N-acetylgalactosaminyltransferase family". Glycobiology. 8 (6): 547–55. PMID 9592121.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Mandel U, Hassan H, Therkildsen MH; et al. (1999). "Expression of polypeptide GalNAc-transferases in stratified epithelia and squamous cell carcinomas: immunohistological evaluation using monoclonal antibodies to three members of the GalNAc-transferase family". Glycobiology. 9 (1): 43–52. PMID 9884405.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Dosaka-Akita H, Kinoshita I, Yamazaki K; et al. (2002). "N-acetylgalactosaminyl transferase-3 is a potential new marker for non-small cell lung cancers". Br. J. Cancer. 87 (7): 751–5. doi:10.1038/sj.bjc.6600536. PMID 12232759.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Argüeso P, Tisdale A, Mandel U; et al. (2003). "The cell-layer- and cell-type-specific distribution of GalNAc-transferases in the ocular surface epithelia is altered during keratinization". Invest. Ophthalmol. Vis. Sci. 44 (1): 86–92. PMID 12506059.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Onitsuka K, Shibao K, Nakayama Y; et al. (2003). "Prognostic significance of UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase-3 (GalNAc-T3) expression in patients with gastric carcinoma". Cancer Sci. 94 (1): 32–6. PMID 12708471.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Yamamoto S, Nakamori S, Tsujie M; et al. (2004). "Expression of uridine diphosphate N-acetyl-alpha-D-galactosamine: polypeptide N-acetylgalactosaminyl transferase 3 in adenocarcinoma of the pancreas". Pathobiology. 71 (1): 12–8. doi:10.1159/000072957. PMID 14555840.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gu C, Oyama T, Osaki T; et al. (2004). "Low expression of polypeptide GalNAc N-acetylgalactosaminyl transferase-3 in lung adenocarcinoma: impact on poor prognosis and early recurrence". Br. J. Cancer. 90 (2): 436–42. doi:10.1038/sj.bjc.6601531. PMID 14735190.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Miyahara N, Shoda J, Kawamoto T; et al. (2004). "Expression of UDP-N-acetyl-alpha-D-galactosamine-polypeptide N-acetylgalactosaminyltransferase isozyme 3 in the subserosal layer correlates with postsurgical survival of pathological tumor stage 2 carcinoma of the gallbladder". Clin. Cancer Res. 10 (6): 2090–9. PMID 15041730.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Topaz O, Shurman DL, Bergman R; et al. (2004). "Mutations in GALNT3, encoding a protein involved in O-linked glycosylation, cause familial tumoral calcinosis". Nat. Genet. 36 (6): 579–81. doi:10.1038/ng1358. PMID 15133511.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ishikawa M, Kitayama J, Kohno K, Nagawa H (2005). "The expression pattern of UDP-N-acetyl-alpha-D-galactosamine-polypeptide N-acetyl-galactosaminyl transferase-3 in squamous cell carcinoma of the esophagus". Pathobiology. 72 (3): 139–45. doi:10.1159/000084117. PMID 15860931.CS1 maint: Multiple names: authors list (link)
• Kimura K, Wakamatsu A, Suzuki Y; et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMID 16344560.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kato K, Jeanneau C, Tarp MA; et al. (2006). "Polypeptide GalNAc-transferase T3 and familial tumoral calcinosis. Secretion of fibroblast growth factor 23 requires O-glycosylation". J. Biol. Chem. 281 (27): 18370–7. doi:10.1074/jbc.M602469200. PMID 16638743.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ichikawa S, Imel EA, Sorenson AH; et al. (2007). "Tumoral calcinosis presenting with eyelid calcifications due to novel missense mutations in the glycosyl transferase domain of the GALNT3 gene". J. Clin. Endocrinol. Metab. 91 (11): 4472–5. doi:10.1210/jc.2006-1247. PMID 16940445.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Barbieri AM, Filopanti M, Bua G, Beck-Peccoz P (2007). "Two novel nonsense mutations in GALNT3 gene are responsible for familial tumoral calcinosis". J. Hum. Genet. 52 (5): 464–8. doi:10.1007/s10038-007-0126-5. PMID 17351710.CS1 maint: Multiple names: authors list (link)
• Inoue T, Eguchi T, Oda Y; et al. (2007). "Expression of GalNAc-T3 and its relationships with clinicopathological factors in 61 extrahepatic bile duct carcinomas analyzed using stepwise sections - special reference to its association with lymph node metastases-". Mod. Pathol. 20 (2): 267–76. doi:10.1038/modpathol.3800700. PMID 17361208.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)