GLRX

Glutaredoxin (thioltransferase)
PDB rendering based on 1b4q.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 1b4q​, 1jhb​
Identifiers
Symbols	GLRX ; GRX; GRX1; MGC117407
External IDs	Template:OMIM5 Template:MGI HomoloGene: 37566
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Glutaredoxin (thioltransferase), also known as GLRX, is a human gene.

Further reading

• Lou MF (2003). "Redox regulation in the lens". Progress in retinal and eye research. 22 (5): 657–82. PMID 12892645.
• Sykes MC, Mowbray AL, Jo H (2007). "Reversible glutathiolation of caspase-3 by glutaredoxin as a novel redox signaling mechanism in tumor necrosis factor-alpha-induced cell death". Circ. Res. 100 (2): 152–4. doi:10.1161/01.RES.0000258171.08020.72. PMID 17272816.CS1 maint: Multiple names: authors list (link)
• Padilla CA, Martínez-Galisteo E, Bárcena JA; et al. (1995). "Purification from placenta, amino acid sequence, structure comparisons and cDNA cloning of human glutaredoxin". Eur. J. Biochem. 227 (1–2): 27–34. PMID 7851394.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Bandyopadhyay S, Gronostajski RM (1994). "Identification of a conserved oxidation-sensitive cysteine residue in the NFI family of DNA-binding proteins". J. Biol. Chem. 269 (47): 29949–55. PMID 7961993.
• Fernando MR, Sumimoto H, Nanri H; et al. (1994). "Cloning and sequencing of the cDNA encoding human glutaredoxin". Biochim. Biophys. Acta. 1218 (2): 229–31. PMID 8018729.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Papov VV, Gravina SA, Mieyal JJ, Biemann K (1994). "The primary structure and properties of thioltransferase (glutaredoxin) from human red blood cells". Protein Sci. 3 (3): 428–34. PMID 8019414.CS1 maint: Multiple names: authors list (link)
• Padilla CA, Spyrou G, Holmgren A (1996). "High-level expression of fully active human glutaredoxin (thioltransferase) in E. coli and characterization of Cys7 to Ser mutant protein". FEBS Lett. 378 (1): 69–73. PMID 8549805.CS1 maint: Multiple names: authors list (link)
• Park JB, Levine M (1996). "Purification, cloning and expression of dehydroascorbic acid-reducing activity from human neutrophils: identification as glutaredoxin". Biochem. J. 315 ( Pt 3): 931–8. PMID 8645179.
• Padilla CA, Bajalica S, Lagercrantz J, Holmgren A (1997). "The gene for human glutaredoxin (GLRX) is localized to human chromosome 5q14". Genomics. 32 (3): 455–7. doi:10.1006/geno.1996.0141. PMID 8838810.CS1 maint: Multiple names: authors list (link)
• Davis DA, Newcomb FM, Starke DW; et al. (1997). "Thioltransferase (glutaredoxin) is detected within HIV-1 and can regulate the activity of glutathionylated HIV-1 protease in vitro". J. Biol. Chem. 272 (41): 25935–40. PMID 9325327.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Park JB, Levine M (1997). "The human glutaredoxin gene: determination of its organization, transcription start point, and promoter analysis". Gene. 197 (1–2): 189–93. PMID 9332366.
• Bandyopadhyay S, Starke DW, Mieyal JJ, Gronostajski RM (1998). "Thioltransferase (glutaredoxin) reactivates the DNA-binding activity of oxidation-inactivated nuclear factor I.". J. Biol. Chem. 273 (1): 392–7. PMID 9417094.CS1 maint: Multiple names: authors list (link)
• Sun C, Berardi MJ, Bushweller JH (1998). "The NMR solution structure of human glutaredoxin in the fully reduced form". J. Mol. Biol. 280 (4): 687–701. doi:10.1006/jmbi.1998.1913. PMID 9677297.CS1 maint: Multiple names: authors list (link)
• Yang Y, Jao S, Nanduri S; et al. (1999). "Reactivity of the human thioltransferase (glutaredoxin) C7S, C25S, C78S, C82S mutant and NMR solution structure of its glutathionyl mixed disulfide intermediate reflect catalytic specificity". Biochemistry. 37 (49): 17145–56. doi:10.1021/bi9806504. PMID 9860827.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Balijepalli S, Tirumalai PS, Swamy KV; et al. (1999). "Rat brain thioltransferase: regional distribution, immunological characterization, and localization by fluorescent in situ hybridization". J. Neurochem. 72 (3): 1170–8. PMID 10037490.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Barrett WC, DeGnore JP, König S; et al. (1999). "Regulation of PTP1B via glutathionylation of the active site cysteine 215". Biochemistry. 38 (20): 6699–705. doi:10.1021/bi990240v. PMID 10350489.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• García-Pardo L, Granados MD, Gaytán F; et al. (1999). "Immunolocalization of glutaredoxin in the human corpus luteum". Mol. Hum. Reprod. 5 (10): 914–9. PMID 10508218.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Mallis RJ, Poland BW, Chatterjee TK; et al. (2000). "Crystal structure of S-glutathiolated carbonic anhydrase III". FEBS Lett. 482 (3): 237–41. PMID 11024467.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Balijepalli S, Boyd MR, Ravindranath V (2001). "Human brain thioltransferase: constitutive expression and localization by fluorescence in situ hybridization". Brain Res. Mol. Brain Res. 85 (1–2): 123–32. PMID 11146114.CS1 maint: Multiple names: authors list (link)
• Qiao F, Xing K, Liu A; et al. (2001). "Human lens thioltransferase: cloning, purification, and function". Invest. Ophthalmol. Vis. Sci. 42 (3): 743–51. PMID 11222536.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)