GNB1

Guanine nucleotide binding protein (G protein), beta polypeptide 1
PDB rendering based on 1a0r.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 1a0r​, 1b9x​, 1b9y​, 1gg2​, 1got​, 1gp2​, 1omw​, 1tbg​, 1xhm​, 2bcj​, 2trc​
Identifiers
Symbols	GNB1 ;
External IDs	Template:OMIM5 Template:MGI HomoloGene: 55532
Gene ontology Molecular function Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Guanine nucleotide binding protein (G protein), beta polypeptide 1, also known as GNB1, is a human gene.

Heterotrimeric guanine nucleotide-binding proteins (G proteins), which integrate signals between receptors and effector proteins, are composed of an alpha, a beta, and a gamma subunit. These subunits are encoded by families of related genes. This gene encodes a beta subunit. Beta subunits are important regulators of alpha subunits, as well as of certain signal transduction receptors and effectors. This gene uses alternative polyadenylation signals.

Further reading

• Downes GB, Gautam N (2000). "The G protein subunit gene families". Genomics. 62 (3): 544–52. doi:10.1006/geno.1999.5992. PMID 10644457.
• Levine MA, Modi WS, O'Brien SJ (1991). "Chromosomal localization of the genes encoding two forms of the G protein beta polypeptide, beta 1 and beta 3, in man". Genomics. 8 (2): 380–6. PMID 1979057.CS1 maint: Multiple names: authors list (link)
• Codina J, Stengel D, Woo SL, Birnbaumer L (1986). "Beta-subunits of the human liver Gs/Gi signal-transducing proteins and those of bovine retinal rod cell transducin are identical". FEBS Lett. 207 (2): 187–92. PMID 3095147.CS1 maint: Multiple names: authors list (link)
• Buhl AM, Osawa S, Johnson GL (1995). "Mitogen-activated protein kinase activation requires two signal inputs from the human anaphylatoxin C5a receptor". J. Biol. Chem. 270 (34): 19828–32. PMID 7649993.CS1 maint: Multiple names: authors list (link)
• Ray K, Kunsch C, Bonner LM, Robishaw JD (1995). "Isolation of cDNA clones encoding eight different human G protein gamma subunits, including three novel forms designated the gamma 4, gamma 10, and gamma 11 subunits". J. Biol. Chem. 270 (37): 21765–71. PMID 7665596.CS1 maint: Multiple names: authors list (link)
• Kozasa T, Gilman AG (1995). "Purification of recombinant G proteins from Sf9 cells by hexahistidine tagging of associated subunits. Characterization of alpha 12 and inhibition of adenylyl cyclase by alpha z.". J. Biol. Chem. 270 (4): 1734–41. PMID 7829508.
• Tsukada S, Simon MI, Witte ON, Katz A (1994). "Binding of beta gamma subunits of heterotrimeric G proteins to the PH domain of Bruton tyrosine kinase". Proc. Natl. Acad. Sci. U.S.A. 91 (23): 11256–60. PMID 7972043.CS1 maint: Multiple names: authors list (link)
• Ueda N, Iñiguez-Lluhi JA, Lee E; et al. (1994). "G protein beta gamma subunits. Simplified purification and properties of novel isoforms". J. Biol. Chem. 269 (6): 4388–95. PMID 8308009.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Wall MA, Coleman DE, Lee E; et al. (1996). "The structure of the G protein heterotrimer Gi alpha 1 beta 1 gamma 2". Cell. 83 (6): 1047–58. PMID 8521505.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Sondek J, Bohm A, Lambright DG; et al. (1996). "Crystal structure of a G-protein beta gamma dimer at 2.1A resolution". Nature. 379 (6563): 369–74. doi:10.1038/379369a0. PMID 8552196.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Andersson B, Wentland MA, Ricafrente JY; et al. (1996). "A "double adaptor" method for improved shotgun library construction". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Mattingly RR, Macara IG (1996). "Phosphorylation-dependent activation of the Ras-GRF/CDC25Mm exchange factor by muscarinic receptors and G-protein beta gamma subunits". Nature. 382 (6588): 268–72. doi:10.1038/382268a0. PMID 8717044.
• De Waard M, Liu H, Walker D; et al. (1997). "Direct binding of G-protein betagamma complex to voltage-dependent calcium channels". Nature. 385 (6615): 446–50. doi:10.1038/385446a0. PMID 9009193.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Huang CL, Jan YN, Jan LY (1997). "Binding of the G protein betagamma subunit to multiple regions of G protein-gated inward-rectifying K+ channels". FEBS Lett. 405 (3): 291–8. PMID 9108307.CS1 maint: Multiple names: authors list (link)
• Yu W, Andersson B, Worley KC; et al. (1997). "Large-scale concatenation cDNA sequencing". Genome Res. 7 (4): 353–8. PMID 9110174.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Qin N, Platano D, Olcese R; et al. (1997). "Direct interaction of gbetagamma with a C-terminal gbetagamma-binding domain of the Ca2+ channel alpha1 subunit is responsible for channel inhibition by G protein-coupled receptors". Proc. Natl. Acad. Sci. U.S.A. 94 (16): 8866–71. PMID 9238069.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Nishida K, Kaziro Y, Satoh T (1999). "Association of the proto-oncogene product dbl with G protein betagamma subunits". FEBS Lett. 459 (2): 186–90. PMID 10518015.CS1 maint: Multiple names: authors list (link)
• Huang L, Shanker YG, Dubauskaite J; et al. (2000). "Ggamma13 colocalizes with gustducin in taste receptor cells and mediates IP3 responses to bitter denatonium". Nat. Neurosci. 2 (12): 1055–62. doi:10.1038/15981. PMID 10570481.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Carman CV, Barak LS, Chen C; et al. (2000). "Mutational analysis of Gbetagamma and phospholipid interaction with G protein-coupled receptor kinase 2". J. Biol. Chem. 275 (14): 10443–52. PMID 10744734.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)