GNLY

Granulysin
PDB rendering based on 1l9l.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 1l9l​
Identifiers
Symbols	GNLY ; 519; D2S69E; LAG-2; LAG2; NKG5; TLA519
External IDs	Template:OMIM5 HomoloGene: 88739
Gene ontology Cellular component Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Granulysin, also known as GNLY, is a human gene.

Granulysin is a protein present in cytotoxic granules of cytotoxic T lymphocytes and natural killer cells. Granulysin is a member of the saposin-like protein (SAPLIP) family and is located in the cytotoxic granules of T cells, which are released upon antigen stimulation. Granulysin has antimicrobial activity against M. tuberculosis and other organisms. Granulysin is alternatively spliced, resulting in the NKG5 and 519 transcripts.

Further reading

• Peña SV, Krensky AM (1997). "Granulysin, a new human cytolytic granule-associated protein with possible involvement in cell-mediated cytotoxicity". Semin. Immunol. 9 (2): 117–25. doi:10.1006/smim.1997.0061. PMID 9194222.
• Krensky AM (2000). "Granulysin: a novel antimicrobial peptide of cytolytic T lymphocytes and natural killer cells". Biochem. Pharmacol. 59 (4): 317–20. PMID 10644038.
• Donlon TA, Krensky AM, Clayberger C (1990). "Localization of the human T lymphocyte activation gene 519 (D2S69E) to chromosome 2p12----q11". Cytogenet. Cell Genet. 53 (4): 230–1. PMID 2209093.CS1 maint: Multiple names: authors list (link)
• Yabe T, McSherry C, Bach FH, Houchins JP (1990). "A cDNA clone expressed in natural killer and T cells that likely encodes a secreted protein". J. Exp. Med. 172 (4): 1159–63. PMID 2212946.CS1 maint: Multiple names: authors list (link)
• Jongstra J, Schall TJ, Dyer BJ; et al. (1987). "The isolation and sequence of a novel gene from a human functional T cell line". J. Exp. Med. 165 (3): 601–14. PMID 2434598.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Houchins JP, Kricek F, Chujor CS; et al. (1993). "Genomic structure of NKG5, a human NK and T cell-specific activation gene". Immunogenetics. 37 (2): 102–7. PMID 8423048.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Peña SV, Hanson DA, Carr BA; et al. (1997). "Processing, subcellular localization, and function of 519 (granulysin), a human late T cell activation molecule with homology to small, lytic, granule proteins". J. Immunol. 158 (6): 2680–8. PMID 9058801.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Stenger S, Hanson DA, Teitelbaum R; et al. (1998). "An antimicrobial activity of cytolytic T cells mediated by granulysin". Science. 282 (5386): 121–5. PMID 9756476.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Hanson DA, Kaspar AA, Poulain FR, Krensky AM (1999). "Biosynthesis of granulysin, a novel cytolytic molecule". Mol. Immunol. 36 (7): 413–22. PMID 10449094.CS1 maint: Multiple names: authors list (link)
• Kaspar AA, Okada S, Kumar J; et al. (2001). "A distinct pathway of cell-mediated apoptosis initiated by granulysin". J. Immunol. 167 (1): 350–6. PMID 11418670.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kitamura N, Koshiba M, Horie O, Ryo R (2002). "Expression of granulysin mRNA in the human megakaryoblastic leukemia cell line CMK". Acta Haematol. 108 (1): 13–8. PMID 12145461.CS1 maint: Multiple names: authors list (link)
• Ma LL, Spurrell JC, Wang JF; et al. (2003). "CD8 T cell-mediated killing of Cryptococcus neoformans requires granulysin and is dependent on CD4 T cells and IL-15". J. Immunol. 169 (10): 5787–95. PMID 12421959.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ericson KG, Fadeel B, Andersson M; et al. (2003). "Sequence analysis of the granulysin and granzyme B genes in familial hemophagocytic lymphohistiocytosis". Hum. Genet. 112 (1): 98–9. doi:10.1007/s00439-002-0841-0. PMID 12483306.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Anderson DH, Sawaya MR, Cascio D; et al. (2003). "Granulysin crystal structure and a structure-derived lytic mechanism". J. Mol. Biol. 325 (2): 355–65. PMID 12488100.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gansert JL, Kiessler V, Engele M; et al. (2003). "Human NKT cells express granulysin and exhibit antimycobacterial activity". J. Immunol. 170 (6): 3154–61. PMID 12626573.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ogawa K, Takamori Y, Suzuki K; et al. (2003). "Granulysin in human serum as a marker of cell-mediated immunity". Eur. J. Immunol. 33 (7): 1925–33. doi:10.1002/eji.200323977. PMID 12884856.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kotsch K, Mashreghi MF, Bold G; et al. (2004). "Enhanced granulysin mRNA expression in urinary sediment in early and delayed acute renal allograft rejection". Transplantation. 77 (12): 1866–75. PMID 15223905.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)