GOT2

Glutamic-oxaloacetic transaminase 2, mitochondrial (aspartate aminotransferase 2)
Identifiers
Symbols	GOT2 ; FLJ40994
External IDs	Template:OMIM5 Template:MGI HomoloGene: 1572
Gene ontology Molecular function Template:GNF GO Cellular component Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Glutamic-oxaloacetic transaminase 2, mitochondrial (aspartate aminotransferase 2), also known as GOT2, is a human gene.

Glutamic-oxaloacetic transaminase is a pyridoxal phosphate-dependent enzyme which exists in cytoplasmic and inner-membrane mitochondrial forms, GOT1 and GOT2, respectively. GOT plays a role in amino acid metabolism and the urea and tricarboxylic acid cycles. The two enzymes are homodimeric and show close homology.

Further reading

• Doonan S, Barra D, Bossa F (1985). "Structural and genetic relationships between cytosolic and mitochondrial isoenzymes". Int. J. Biochem. 16 (12): 1193–9. PMID 6397370.CS1 maint: Multiple names: authors list (link)
• Furuya E, Yoshida Y, Tagawa K (1979). "Interaction of mitochondrial aspartate aminotransferase with negatively charged lecithin liposomes". J. Biochem. 85 (5): 1157–63. PMID 376500.CS1 maint: Multiple names: authors list (link)
• Craig IW, Tolley E, Bobrow M, van Heyningen V (1979). "Assignment of a gene necessary for the expression of mitochondrial glutamic-oxaloacetic transaminase in human-mouse hybrid cells". Cytogenet. Cell Genet. 22 (1–6): 190–4. PMID 752471.CS1 maint: Multiple names: authors list (link)
• Pol S, Bousquet-Lemercier B, Pavé-Preux M; et al. (1989). "Chromosomal localization of human aspartate aminotransferase genes by in situ hybridization". Hum. Genet. 83 (2): 159–64. PMID 2777255.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Fahien LA, Kmiotek EH, MacDonald MJ; et al. (1988). "Regulation of malate dehydrogenase activity by glutamate, citrate, alpha-ketoglutarate, and multienzyme interaction". J. Biol. Chem. 263 (22): 10687–97. PMID 2899080.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Pol S, Bousquet-Lemercier B, Pave-Preux M; et al. (1989). "Nucleotide sequence and tissue distribution of the human mitochondrial aspartate aminotransferase mRNA". Biochem. Biophys. Res. Commun. 157 (3): 1309–15. PMID 3207426.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Fahien LA, Kmiotek EH, Woldegiorgis G; et al. (1985). "Regulation of aminotransferase-glutamate dehydrogenase interactions by carbamyl phosphate synthase-I, Mg2+ plus leucine versus citrate and malate". J. Biol. Chem. 260 (10): 6069–79. PMID 3997814.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Martini F, Angelaccio S, Barra D; et al. (1985). "The primary structure of mitochondrial aspartate aminotransferase from human heart". Biochim. Biophys. Acta. 832 (1): 46–51. PMID 4052435.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Davidson RG, Cortner JA, Rattazzi MC; et al. (1970). "Genetic polymorphisms of human mitochondrial glutamic oxaloacetic transaminase". Science. 169 (943): 391–2. PMID 5450376.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ford GC, Eichele G, Jansonius JN (1980). "Three-dimensional structure of a pyridoxal-phosphate-dependent enzyme, mitochondrial aspartate aminotransferase". Proc. Natl. Acad. Sci. U.S.A. 77 (5): 2559–63. PMID 6930651.CS1 maint: Multiple names: authors list (link)
• Jeremiah SJ, Povey S, Burley MW; et al. (1982). "Mapping studies on human mitochondrial glutamate oxaloacetate transaminase". Ann. Hum. Genet. 46 (Pt 2): 145–52. PMID 7114792.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Tolley E, van Heyningen V, Brown R; et al. (1981). "Assignment to chromosome 16 of a gene necessary for the expression of human mitochondrial glutamate oxaloacetate transaminase (aspartate aminotransferase) (E.C. 2.6.1.1.)". Biochem. Genet. 18 (9–10): 947–54. PMID 7225087.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Lain B, Iriarte A, Mattingly JR; et al. (1995). "Structural features of the precursor to mitochondrial aspartate aminotransferase responsible for binding to hsp70". J. Biol. Chem. 270 (42): 24732–9. PMID 7559589.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. PMID 8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K; et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. PMID 9373149.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Rual JF, Venkatesan K, Hao T; et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)