GRB14
| Growth factor receptor-bound protein 14 | |||||||||||||
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 PDB rendering based on 2aug. | |||||||||||||
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| Symbols | GRB14 ; | ||||||||||||
| External IDs | Template:OMIM5 Template:MGI HomoloGene: 3303 | ||||||||||||
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| Species | Human | Mouse | |||||||||||
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Growth factor receptor-bound protein 14, also known as GRB14, is a human gene.[1]
The product of this gene belongs to a small family of adapter proteins that are known to interact with a number of receptor tyrosine kinases and signaling molecules. This gene encodes a growth factor receptor-binding protein that interacts with insulin receptors and insulin-like growth-factor receptors. This protein likely has an inhibitory effect on receptor tyrosine kinase signaling and, in particular, on insulin receptor signaling. This gene may play a role in signaling pathways that regulate growth and metabolism. Transcript variants have been reported for this gene, but their full-length natures have not been determined to date.[1]
References
Further reading
- Han DC, Shen TL, Guan JL (2001). "The Grb7 family proteins: structure, interactions with other signaling molecules and potential cellular functions". Oncogene. 20 (44): 6315–21. doi:10.1038/sj.onc.1204775. PMID 11607834.
- Daly RJ, Sanderson GM, Janes PW, Sutherland RL (1996). "Cloning and characterization of GRB14, a novel member of the GRB7 gene family". J. Biol. Chem. 271 (21): 12502–10. PMID 8647858.
- Baker E, Sutherland GR, Sutherland RL, Daly RJ (1997). "Assignment of the human GRB14 gene to chromosome 2q22-q24 by fluorescence in situ hybridization". Genomics. 36 (1): 218–20. doi:10.1006/geno.1996.0453. PMID 8812444.
- Kasus-Jacobi A, Perdereau D, Auzan C; et al. (1998). "Identification of the rat adapter Grb14 as an inhibitor of insulin actions". J. Biol. Chem. 273 (40): 26026–35. PMID 9748281.
- Jones N, Master Z, Jones J; et al. (1999). "Identification of Tek/Tie2 binding partners. Binding to a multifunctional docking site mediates cell survival and migration". J. Biol. Chem. 274 (43): 30896–905. PMID 10521483.
- Reilly JF, Mickey G, Maher PA (2000). "Association of fibroblast growth factor receptor 1 with the adaptor protein Grb14. Characterization of a new receptor binding partner". J. Biol. Chem. 275 (11): 7771–8. PMID 10713090.
- Hemming R, Agatep R, Badiani K; et al. (2001). "Human growth factor receptor bound 14 binds the activated insulin receptor and alters the insulin-stimulated tyrosine phosphorylation levels of multiple proteins". Biochem. Cell Biol. 79 (1): 21–32. PMID 11235915.
- Lyons RJ, Deane R, Lynch DK; et al. (2001). "Identification of a novel human tankyrase through its interaction with the adaptor protein Grb14". J. Biol. Chem. 276 (20): 17172–80. doi:10.1074/jbc.M009756200. PMID 11278563.
- Béréziat V, Kasus-Jacobi A, Perdereau D; et al. (2002). "Inhibition of insulin receptor catalytic activity by the molecular adapter Grb14". J. Biol. Chem. 277 (7): 4845–52. doi:10.1074/jbc.M106574200. PMID 11726652.
- Cariou B, Perdereau D, Cailliau K; et al. (2002). "The adapter protein ZIP binds Grb14 and regulates its inhibitory action on insulin signaling by recruiting protein kinase Czeta". Mol. Cell. Biol. 22 (20): 6959–70. PMID 12242277.
- Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
- King CC, Newton AC (2004). "The adaptor protein Grb14 regulates the localization of 3-phosphoinositide-dependent kinase-1". J. Biol. Chem. 279 (36): 37518–27. doi:10.1074/jbc.M405340200. PMID 15210700.
- Scharf PJ, Witney J, Daly R, Lyons BA (2005). "Solution structure of the human Grb14-SH2 domain and comparison with the structures of the human Grb7-SH2/erbB2 peptide complex and human Grb10-SH2 domain". Protein Sci. 13 (9): 2541–6. doi:10.1110/ps.04884704. PMID 15322292.
- Kairouz R, Parmar J, Lyons RJ; et al. (2005). "Hormonal regulation of the Grb14 signal modulator and its role in cell cycle progression of MCF-7 human breast cancer cells". J. Cell. Physiol. 203 (1): 85–93. doi:10.1002/jcp.20199. PMID 15372466.
- Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
- Depetris RS, Hu J, Gimpelevich I; et al. (2006). "Structural basis for inhibition of the insulin receptor by the adaptor protein Grb14". Mol. Cell. 20 (2): 325–33. doi:10.1016/j.molcel.2005.09.001. PMID 16246733.
- Park JJ, Berggren JR, Hulver MW; et al. (2006). "GRB14, GPD1, and GDF8 as potential network collaborators in weight loss-induced improvements in insulin action in human skeletal muscle". Physiol. Genomics. 27 (2): 114–21. doi:10.1152/physiolgenomics.00045.2006. PMID 16849634.
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