GRID2

Glutamate receptor, ionotropic, delta 2
Identifiers
Symbols	GRID2 ; MGC117022; MGC117023; MGC117024
External IDs	Template:OMIM5 Template:MGI HomoloGene: 74399
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO
RNA expression pattern
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Glutamate receptor, ionotropic, delta 2, also known as GRID2, is a human gene.

Human glutamate receptor delta-2 (GRID2) is a relatively new member of the family of ionotropic glutamate receptors which are the predominant excitatory neurotransmitter receptors in the mammalian brain. GRID2 is a predicted 1,007 amino acid protein that shares 97% identity with the mouse homolog which is expressed selectively in cerebellar Purkinje cells. A point mutation in mouse GRID2, associated with the phenotype named 'lurcher', in the heterozygous state leads to ataxia resulting from selective, cell-autonomous apoptosis of cerebellar Purkinje cells during postnatal development. Mice homozygous for this mutation die shortly after birth from massive loss of mid- and hindbrain neurons during late embryogenesis. This strongly suggests a role for GRID2 in neuronal apoptotic death.

Further reading

• Araki K, Meguro H, Kushiya E; et al. (1994). "Selective expression of the glutamate receptor channel delta 2 subunit in cerebellar Purkinje cells". Biochem. Biophys. Res. Commun. 197 (3): 1267–76. doi:10.1006/bbrc.1993.2614. PMID 7506541.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Hu W, Zuo J, De Jager PL, Heintz N (1998). "The human glutamate receptor delta 2 gene (GRID2) maps to chromosome 4q22". Genomics. 47 (1): 143–5. doi:10.1006/geno.1997.5108. PMID 9465309.CS1 maint: Multiple names: authors list (link)
• "Toward a complete human genome sequence". Genome Res. 8 (11): 1097–108. 1999. PMID 9847074.
• Roche KW, Ly CD, Petralia RS; et al. (1999). "Postsynaptic density-93 interacts with the delta2 glutamate receptor subunit at parallel fiber synapses". J. Neurosci. 19 (10): 3926–34. PMID 10234023.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Hironaka K, Umemori H, Tezuka T; et al. (2000). "The protein-tyrosine phosphatase PTPMEG interacts with glutamate receptor delta 2 and epsilon subunits". J. Biol. Chem. 275 (21): 16167–73. doi:10.1074/jbc.M909302199. PMID 10748123.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Miyagi Y, Yamashita T, Fukaya M; et al. (2002). "Delphilin: a novel PDZ and formin homology domain-containing protein that synaptically colocalizes and interacts with glutamate receptor delta 2 subunit". J. Neurosci. 22 (3): 803–14. PMID 11826110.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ly CD, Roche KW, Lee HK, Wenthold RJ (2002). "Identification of rat EMAP, a delta-glutamate receptor binding protein". Biochem. Biophys. Res. Commun. 291 (1): 85–90. doi:10.1006/bbrc.2002.6413. PMID 11829466.CS1 maint: Multiple names: authors list (link)
• Yue Z, Horton A, Bravin M; et al. (2002). "A novel protein complex linking the delta 2 glutamate receptor and autophagy: implications for neurodegeneration in lurcher mice". Neuron. 35 (5): 921–33. PMID 12372286.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kohda K, Kamiya Y, Matsuda S; et al. (2003). "Heteromer formation of delta2 glutamate receptors with AMPA or kainate receptors". Brain Res. Mol. Brain Res. 110 (1): 27–37. PMID 12573530.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Yap CC, Muto Y, Kishida H; et al. (2003). "PKC regulates the delta2 glutamate receptor interaction with S-SCAM/MAGI-2 protein". Biochem. Biophys. Res. Commun. 301 (4): 1122–8. PMID 12589829.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Sonoda T, Mochizuki C, Yamashita T; et al. (2006). "Binding of glutamate receptor delta2 to its scaffold protein, Delphilin, is regulated by PKA". Biochem. Biophys. Res. Commun. 350 (3): 748–52. doi:10.1016/j.bbrc.2006.09.109. PMID 17027646.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)