GRK5

G protein-coupled receptor kinase 5
Identifiers
Symbols	GRK5 ; GPRK5
External IDs	Template:OMIM5 Template:MGI HomoloGene: 3879
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

G protein-coupled receptor kinase 5, also known as GRK5, is a human gene.

This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily of the Ser/Thr protein kinase family. The protein phosphorylates the activated forms of G protein-coupled receptors thus initiating their deactivation. It has also been shown to play a role in regulating the motility of polymorphonuclear leukocytes (PMNs).

Further reading

• Kunapuli P, Benovic JL (1993). "Cloning and expression of GRK5: a member of the G protein-coupled receptor kinase family". Proc. Natl. Acad. Sci. U.S.A. 90 (12): 5588–92. PMID 7685906.
• Bullrich F, Druck T, Kunapuli P; et al. (1995). "Chromosomal mapping of the genes GPRK5 and GPRK6 encoding G protein-coupled receptor kinases GRK5 and GRK6". Cytogenet. Cell Genet. 70 (3–4): 250–4. PMID 7789183.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kunapuli P, Gurevich VV, Benovic JL (1994). "Phospholipid-stimulated autophosphorylation activates the G protein-coupled receptor kinase GRK5". J. Biol. Chem. 269 (14): 10209–12. PMID 8144599.CS1 maint: Multiple names: authors list (link)
• Kunapuli P, Onorato JJ, Hosey MM, Benovic JL (1994). "Expression, purification, and characterization of the G protein-coupled receptor kinase GRK5". J. Biol. Chem. 269 (2): 1099–105. PMID 8288567.CS1 maint: Multiple names: authors list (link)
• Nagayama Y, Tanaka K, Hara T; et al. (1996). "Involvement of G protein-coupled receptor kinase 5 in homologous desensitization of the thyrotropin receptor". J. Biol. Chem. 271 (17): 10143–8. PMID 8626574.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Oppermann M, Freedman NJ, Alexander RW, Lefkowitz RJ (1996). "Phosphorylation of the type 1A angiotensin II receptor by G protein-coupled receptor kinases and protein kinase C.". J. Biol. Chem. 271 (22): 13266–72. PMID 8662816.CS1 maint: Multiple names: authors list (link)
• Fredericks ZL, Pitcher JA, Lefkowitz RJ (1996). "Identification of the G protein-coupled receptor kinase phosphorylation sites in the human beta2-adrenergic receptor". J. Biol. Chem. 271 (23): 13796–803. PMID 8662852.CS1 maint: Multiple names: authors list (link)
• Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. PMID 8889548.CS1 maint: Multiple names: authors list (link)
• Pronin AN, Carman CV, Benovic JL (1998). "Structure-function analysis of G protein-coupled receptor kinase-5. Role of the carboxyl terminus in kinase regulation". J. Biol. Chem. 273 (47): 31510–8. PMID 9813065.CS1 maint: Multiple names: authors list (link)
• Premont RT, Claing A, Vitale N; et al. (1998). "beta2-Adrenergic receptor regulation by GIT1, a G protein-coupled receptor kinase-associated ADP ribosylation factor GTPase-activating protein". Proc. Natl. Acad. Sci. U.S.A. 95 (24): 14082–7. PMID 9826657.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Carman CV, Lisanti MP, Benovic JL (1999). "Regulation of G protein-coupled receptor kinases by caveolin". J. Biol. Chem. 274 (13): 8858–64. PMID 10085129.CS1 maint: Multiple names: authors list (link)
• Brenninkmeijer CB, Price SA, López Bernal A, Phaneuf S (1999). "Expression of G-protein-coupled receptor kinases in pregnant term and non-pregnant human myometrium". J. Endocrinol. 162 (3): 401–8. PMID 10467231.CS1 maint: Multiple names: authors list (link)
• Okochi M, Walter J, Koyama A; et al. (2000). "Constitutive phosphorylation of the Parkinson's disease associated alpha-synuclein". J. Biol. Chem. 275 (1): 390–7. PMID 10617630.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Pronin AN, Morris AJ, Surguchov A, Benovic JL (2000). "Synucleins are a novel class of substrates for G protein-coupled receptor kinases". J. Biol. Chem. 275 (34): 26515–22. doi:10.1074/jbc.M003542200. PMID 10852916.CS1 maint: Multiple names: authors list (link)
• Berrada K, Plesnicher CL, Luo X, Thibonnier M (2000). "Dynamic interaction of human vasopressin/oxytocin receptor subtypes with G protein-coupled receptor kinases and protein kinase C after agonist stimulation". J. Biol. Chem. 275 (35): 27229–37. doi:10.1074/jbc.M002288200. PMID 10858434.CS1 maint: Multiple names: authors list (link)
• Zhou H, Yan F, Tai HH (2001). "Phosphorylation and desensitization of the human thromboxane receptor-alpha by G protein-coupled receptor kinases". J. Pharmacol. Exp. Ther. 298 (3): 1243–51. PMID 11504827.CS1 maint: Multiple names: authors list (link)
• Blaukat A, Pizard A, Breit A; et al. (2001). "Determination of bradykinin B2 receptor in vivo phosphorylation sites and their role in receptor function". J. Biol. Chem. 276 (44): 40431–40. doi:10.1074/jbc.M107024200. PMID 11517230.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Hu LA, Chen W, Premont RT; et al. (2002). "G protein-coupled receptor kinase 5 regulates beta 1-adrenergic receptor association with PSD-95". J. Biol. Chem. 277 (2): 1607–13. doi:10.1074/jbc.M107297200. PMID 11700307.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Warabi K, Richardson MD, Barry WT; et al. (2002). "Human substance P receptor undergoes agonist-dependent phosphorylation by G protein-coupled receptor kinase 5 in vitro". FEBS Lett. 521 (1–3): 140–4. PMID 12067742.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)