GSTT2

Glutathione S-transferase theta 2
PDB rendering based on 1ljr.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 1ljr​, 2ljr​, 3ljr​
Identifiers
Symbols	GSTT2 ; GSTT2
External IDs	Template:OMIM5 Template:MGI HomoloGene: 37358
Gene ontology Molecular function Template:GNF GO Template:GNF GO
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Glutathione S-transferase theta 2, also known as GSTT2, is a human gene.

Glutathione S-transferase (GSTs) theta 2 (GSTT2) is a member of a superfamily of proteins that catalyze the conjugation of reduced glutathione to a variety of electrophilic and hydrophobic compounds. Human GSTs can be divided into five main classes: Alpha, Mu, Pi, Theta, and Zeta. The theta class members GSTT1 and GSTT2 share 55% amino acid sequence identity and both are thought to have an important role in human carcinogenesis. The theta genes have a similar structure, being composed of five exons with identical exon/intron boundaries.

Further reading

• Hussey AJ, Hayes JD (1992). "Characterization of a human class-Theta glutathione S-transferase with activity towards 1-menaphthyl sulphate". Biochem. J. 286 ( Pt 3): 929–35. PMID 1417752.
• Tan KL, Webb GC, Baker RT, Board PG (1995). "Molecular cloning of a cDNA and chromosomal localization of a human theta-class glutathione S-transferase gene (GSTT2) to chromosome 22". Genomics. 25 (2): 381–7. PMID 7789971.CS1 maint: Multiple names: authors list (link)
• Whittington AT, Webb GC, Baker RT, Board PG (1996). "Characterization of a cDNA and gene encoding the mouse theta class glutathione transferase mGSTT2 and its localization to chromosome 10B5-C1". Genomics. 33 (1): 105–11. doi:10.1006/geno.1996.0165. PMID 8617493.CS1 maint: Multiple names: authors list (link)
• Webb G, Vaska V, Coggan M, Board P (1996). "Chromosomal localization of the gene for the human theta class glutathione transferase (GSTT1)". Genomics. 33 (1): 121–3. doi:10.1006/geno.1996.0167. PMID 8617495.CS1 maint: Multiple names: authors list (link)
• Mainwaring GW, Williams SM, Foster JR; et al. (1996). "The distribution of theta-class glutathione S-transferases in the liver and lung of mouse, rat and human". Biochem. J. 318 ( Pt 1): 297–303. PMID 8761485.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. PMID 8889548.CS1 maint: Multiple names: authors list (link)
• Chelvanayagam G, Wilce MC, Parker MW; et al. (1997). "Homology model for the human GSTT2 Theta class glutathione transferase". Proteins. 27 (1): 118–30. PMID 9037717.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Rossjohn J, McKinstry WJ, Oakley AJ; et al. (1998). "Human theta class glutathione transferase: the crystal structure reveals a sulfate-binding pocket within a buried active site". Structure. 6 (3): 309–22. PMID 9551553.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Coggan M, Whitbread L, Whittington A, Board P (1998). "Structure and organization of the human theta-class glutathione S-transferase and D-dopachrome tautomerase gene complex". Biochem. J. 334 ( Pt 3): 617–23. PMID 9729470.CS1 maint: Multiple names: authors list (link)
• de Bruin WC, Wagenmans MJ, Board PG, Peters WH (1999). "Expression of glutathione S-transferase theta class isoenzymes in human colorectal and gastric cancers". Carcinogenesis. 20 (8): 1453–7. PMID 10426791.CS1 maint: Multiple names: authors list (link)
• Dunham I, Shimizu N, Roe BA; et al. (1999). "The DNA sequence of human chromosome 22". Nature. 402 (6761): 489–95. doi:10.1038/990031. PMID 10591208.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• de Bruin WC, Wagenmans MJ, Peters WH (2000). "Expression of glutathione S-transferase alpha, P1-1 and T1-1 in the human gastrointestinal tract". Jpn. J. Cancer Res. 91 (3): 310–6. PMID 10760690.CS1 maint: Multiple names: authors list (link)
• Sprenger R, Schlagenhaufer R, Kerb R; et al. (2001). "Characterization of the glutathione S-transferase GSTT1 deletion: discrimination of all genotypes by polymerase chain reaction indicates a trimodular genotype-phenotype correlation". Pharmacogenetics. 10 (6): 557–65. PMID 10975610.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Venter JC, Adams MD, Myers EW; et al. (2001). "The sequence of the human genome". Science. 291 (5507): 1304–51. doi:10.1126/science.1058040. PMID 11181995.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• De Maria F, Pedersen JZ, Caccuri AM; et al. (2004). "The specific interaction of dinitrosyl-diglutathionyl-iron complex, a natural NO carrier, with the glutathione transferase superfamily: suggestion for an evolutionary pressure in the direction of the storage of nitric oxide". J. Biol. Chem. 278 (43): 42283–93. doi:10.1074/jbc.M305568200. PMID 12871945.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Collins JE, Wright CL, Edwards CA; et al. (2005). "A genome annotation-driven approach to cloning the human ORFeome". Genome Biol. 5 (10): R84. doi:10.1186/gb-2004-5-10-r84. PMID 15461802.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Jang SG, Kim IJ, Kang HC; et al. (2007). "GSTT2 promoter polymorphisms and colorectal cancer risk". BMC Cancer. 7: 16. doi:10.1186/1471-2407-7-16. PMID 17250773.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)