GYPE

Glycophorin E
Identifiers
Symbols	GYPE ; MNS; GPE; MiIX
External IDs	Template:OMIM5 HomoloGene: 88655
Gene ontology Cellular component Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Glycophorin E, also known as GYPE, is a human gene.

The protein encoded by this gene is a sialoglycoprotein and a type I membrane protein. It is a member of a gene family with GPA and GPB genes. This encoded protein might carry the M blood group antigen. GYPA, GYPB, and GYPE are organized in tandem on chromosome 4. This gene might have derived from an ancestral gene common to the GPB gene by gene duplication. Two alternatively spliced transcript variants encoding the same protein have been described for this gene.

Further reading

• Cartron JP, Rahuel C (1992). "Human erythrocyte glycophorins: protein and gene structure analyses". Transfusion medicine reviews. 6 (2): 63–92. PMID 1591491.
• Huang CH, Skov F, Daniels G; et al. (1992). "Molecular analysis of human glycophorin MiIX gene shows a silent segment transfer and untemplated mutation resulting from gene conversion via sequence repeats". Blood. 80 (9): 2379–87. PMID 1421409.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Vignal A, London J, Rahuel C, Cartron JP (1991). "Promoter sequence and chromosomal organization of the genes encoding glycophorins A, B and E.". Gene. 95 (2): 289–93. PMID 2249783.CS1 maint: Multiple names: authors list (link)
• Kudo S, Fukuda M (1990). "Identification of a novel human glycophorin, glycophorin E, by isolation of genomic clones and complementary DNA clones utilizing polymerase chain reaction". J. Biol. Chem. 265 (2): 1102–10. PMID 2295603.
• Vignal A, Rahuel C, London J; et al. (1990). "A novel gene member of the human glycophorin A and B gene family. Molecular cloning and expression". Eur. J. Biochem. 191 (3): 619–25. PMID 2390989.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kudo S, Fukuda M (1994). "Contribution of gene conversion to the retention of the sequence for M blood group type determinant in glycophorin E gene". J. Biol. Chem. 269 (37): 22969–74. PMID 7521873.
• Onda M, Fukuda M (1995). "Detailed physical mapping of the genes encoding glycophorins A, B and E, as revealed by P1 plasmids containing human genomic DNA". Gene. 159 (2): 225–30. PMID 7622054.
• Kudo S, Onda M, Fukuda M (1995). "Characterization of glycophorin A transcripts: control by the common erythroid-specific promoter and alternative usage of different polyadenylation signals". J. Biochem. 116 (1): 183–92. PMID 7798177.CS1 maint: Multiple names: authors list (link)
• Huang CH, Chen Y, Blumenfeld OO (2000). "A novel St(a) glycophorin produced via gene conversion of pseudoexon III from glycophorin E to glycophorin A gene". Hum. Mutat. 15 (6): 533–40. doi:10.1002/1098-1004(200006)15:6<533::AID-HUMU5>3.0.CO;2-R. PMID 10862083.CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Wang HY, Tang H, Shen CK, Wu CI (2004). "Rapidly evolving genes in human. I. The glycophorins and their possible role in evading malaria parasites". Mol. Biol. Evol. 20 (11): 1795–804. doi:10.1093/molbev/msg185. PMID 12949139.CS1 maint: Multiple names: authors list (link)
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)