GZMB
Granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1) | |||||||||||
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PDB rendering based on 1fq3. | |||||||||||
Identifiers | |||||||||||
Symbols | GZMB ; HLP; CTLA1; CCPI; CGL-1; CGL1; CSP-B; CSPB; CTSGL1; SECT | ||||||||||
External IDs | Template:OMIM5 Template:MGI HomoloGene: 20876 | ||||||||||
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RNA expression pattern | |||||||||||
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Template:GNF Ortholog box | |||||||||||
Species | Human | Mouse | |||||||||
Entrez | n/a | n/a | |||||||||
Ensembl | n/a | n/a | |||||||||
UniProt | n/a | n/a | |||||||||
RefSeq (mRNA) | n/a | n/a | |||||||||
RefSeq (protein) | n/a | n/a | |||||||||
Location (UCSC) | n/a | n/a | |||||||||
PubMed search | n/a | n/a |
WikiDoc Resources for GZMB |
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Evidence Based Medicine |
Clinical Trials |
Ongoing Trials on GZMB at Clinical Trials.gov Clinical Trials on GZMB at Google
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Guidelines / Policies / Govt |
US National Guidelines Clearinghouse on GZMB
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Patient Resources / Community |
Directions to Hospitals Treating GZMB Risk calculators and risk factors for GZMB
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Healthcare Provider Resources |
Continuing Medical Education (CME) |
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Experimental / Informatics |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1), also known as GZMB, is a human gene.
Cytolytic T lymphocytes (CTL) and natural killer (NK) cells share the remarkable ability to recognize, bind, and lyse specific target cells. They are thought to protect their host by lysing cells bearing on their surface 'nonself' antigens, usually peptides or proteins resulting from infection by intracellular pathogens. The protein encoded by this gene is crucial for the rapid induction of target cell apoptosis by CTL in cell-mediated immune response.[1]
See also
References
Further reading
- Trapani JA (1996). "Target cell apoptosis induced by cytotoxic T cells and natural killer cells involves synergy between the pore-forming protein, perforin, and the serine protease, granzyme B.". Australian and New Zealand journal of medicine. 25 (6): 793–9. PMID 8770355.
- Cohen GM (1997). "Caspases: the executioners of apoptosis". Biochem. J. 326 ( Pt 1): 1–16. PMID 9337844.
- Trapani JA, Sutton VR (2004). "Granzyme B: pro-apoptotic, antiviral and antitumor functions". Curr. Opin. Immunol. 15 (5): 533–43. PMID 14499262.