GZMK

Granzyme K (granzyme 3; tryptase II)
PDB rendering based on 1mza.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 1mza​, 1mzd​
Identifiers
Symbols	GZMK ; TRYP2
External IDs	Template:OMIM5 Template:MGI HomoloGene: 20485
Gene ontology Molecular function Template:GNF GO Cellular component Template:GNF GO Biological process Template:GNF GO
RNA expression pattern
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Granzyme K (granzyme 3; tryptase II), also known as GZMK, is a human gene.

This gene product is a member of a group of related serine proteases from the cytoplasmic granules of cytotoxic lymphocytes. Cytolytic T lymphocytes (CTL) and natural killer (NK) cells share the remarkable ability to recognize, bind, and lyse specific target cells. They are thought to protect their host by lysing cells bearing on their surface 'nonself' antigens, usually peptides or proteins resulting from infection by intracellular pathogens. The protein described here lacks consensus sequences for N-glycosylation present in other granzymes.

Further reading

• Smyth MJ, O'Connor MD, Trapani JA (1996). "Granzymes: a variety of serine protease specificities encoded by genetically distinct subfamilies". J. Leukoc. Biol. 60 (5): 555–62. PMID 8929545.CS1 maint: Multiple names: authors list (link)
• Shi L, Kam CM, Powers JC; et al. (1993). "Purification of three cytotoxic lymphocyte granule serine proteases that induce apoptosis through distinct substrate and target cell interactions". J. Exp. Med. 176 (6): 1521–9. PMID 1460416.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Hameed A, Lowrey DM, Lichtenheld M, Podack ER (1988). "Characterization of three serine esterases isolated from human IL-2 activated killer cells". J. Immunol. 141 (9): 3142–7. PMID 3262682.CS1 maint: Multiple names: authors list (link)
• Przetak MM, Yoast S, Schmidt BF (1995). "Cloning of cDNA for human granzyme 3". FEBS Lett. 364 (3): 268–71. PMID 7758581.CS1 maint: Multiple names: authors list (link)
• Baker E, Sayers TJ, Sutherland GR, Smyth MJ (1994). "The genes encoding NK cell granule serine proteases, human tryptase-2 (TRYP2) and human granzyme A (HFSP), both map to chromosome 5q11-q12 and define a new locus for cytotoxic lymphocyte granule tryptases". Immunogenetics. 40 (3): 235–7. PMID 8039831.CS1 maint: Multiple names: authors list (link)
• Sayers TJ, Lloyd AR, McVicar DW; et al. (1996). "Cloning and expression of a second human natural killer cell granule tryptase, HNK-Tryp-2/granzyme 3". J. Leukoc. Biol. 59 (5): 763–8. PMID 8656064.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Hink-Schauer C, Estébanez-Perpiñá E, Wilharm E; et al. (2003). "The 2.2-A crystal structure of human pro-granzyme K reveals a rigid zymogen with unusual features". J. Biol. Chem. 277 (52): 50923–33. doi:10.1074/jbc.M207962200. PMID 12384499.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Fajardo I, Pejler G (2003). "Formation of active monomers from tetrameric human beta-tryptase". Biochem. J. 369 (Pt 3): 603–10. doi:10.1042/BJ20021418. PMID 12387726.
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Zhao T, Zhang H, Guo Y; et al. (2007). "Granzyme K cleaves the nucleosome assembly protein SET to induce single-stranded DNA nicks of target cells". Cell Death Differ. 14 (3): 489–99. doi:10.1038/sj.cdd.4402040. PMID 17008916.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Zhao T, Zhang H, Guo Y, Fan Z (2007). "Granzyme K directly processes bid to release cytochrome c and endonuclease G leading to mitochondria-dependent cell death". J. Biol. Chem. 282 (16): 12104–11. doi:10.1074/jbc.M611006200. PMID 17308307.CS1 maint: Multiple names: authors list (link)
• Rucevic M, Fast LD, Jay GD; et al. (2007). "Altered levels and molecular forms of granzyme k in plasma from septic patients". Shock. 27 (5): 488–93. doi:10.1097/01.shk.0000246905.24895.e5. PMID 17438453.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)