HAVCR2

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Hepatitis A virus cellular receptor 2
Identifiers
Symbols HAVCR2 ; FLJ14428; KIM-3; TIM3; TIMD3; Tim-3
External IDs Template:OMIM5 HomoloGene: 87084
RNA expression pattern
More reference expression data
Orthologs
Template:GNF Ortholog box
Species Human Mouse
Entrez n/a n/a
Ensembl n/a n/a
UniProt n/a n/a
RefSeq (mRNA) n/a n/a
RefSeq (protein) n/a n/a
Location (UCSC) n/a n/a
PubMed search n/a n/a

Hepatitis A virus cellular receptor 2, also known as HAVCR2, is a human gene.[1]

CD4 (MIM 186940)-positive T helper lymphocytes can be divided into types 1 (Th1) and 2 (Th2) on the basis of their cytokine secretion patterns. Th1 cells and their associated cytokines are involved in cell-mediated immunity to intracellular pathogens and delayed-type hypersensitivity reactions, whereas Th2 cells are involved in the control of extracellular helminthic infections and the promotion of atopic and allergic diseases. The 2 types of cells also cross-regulate the functions of the other. TIM3 is a Th1-specific cell surface protein that regulates macrophage activation and enhances the severity of experimental autoimmune encephalomyelitis in mice.[supplied by OMIM][1]

References

  1. ↑ 1.0 1.1 "Entrez Gene: HAVCR2 hepatitis A virus cellular receptor 2".

Further reading

  • Anderson DE (2007). "TIM-3 as a therapeutic target in human inflammatory diseases". Expert Opin. Ther. Targets. 11 (8): 1005–9. doi:10.1517/14728222.11.8.1005. PMID 17665973.
  • Monney L, Sabatos CA, Gaglia JL; et al. (2002). "Th1-specific cell surface protein Tim-3 regulates macrophage activation and severity of an autoimmune disease". Nature. 415 (6871): 536–41. doi:10.1038/415536a. PMID 11823861.
  • Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
  • Sánchez-Fueyo A, Tian J, Picarella D; et al. (2003). "Tim-3 inhibits T helper type 1-mediated auto- and alloimmune responses and promotes immunological tolerance". Nat. Immunol. 4 (11): 1093–101. doi:10.1038/ni987. PMID 14556005.
  • Sabatos CA, Chakravarti S, Cha E; et al. (2003). "Interaction of Tim-3 and Tim-3 ligand regulates T helper type 1 responses and induction of peripheral tolerance". Nat. Immunol. 4 (11): 1102–10. doi:10.1038/ni988. PMID 14556006.
  • Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Khademi M, Illés Z, Gielen AW; et al. (2004). "T Cell Ig- and mucin-domain-containing molecule-3 (TIM-3) and TIM-1 molecules are differentially expressed on human Th1 and Th2 cells and in cerebrospinal fluid-derived mononuclear cells in multiple sclerosis". J. Immunol. 172 (11): 7169–76. PMID 15153541.
  • Chae SC, Park YR, Shim SC; et al. (2005). "The polymorphisms of Th1 cell surface gene Tim-3 are associated in a Korean population with rheumatoid arthritis". Immunol. Lett. 95 (1): 91–5. doi:10.1016/j.imlet.2004.06.008. PMID 15325803.
  • Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
  • Chae SC, Park YR, Lee YC; et al. (2005). "The association of TIM-3 gene polymorphism with atopic disease in Korean population". Hum. Immunol. 65 (12): 1427–31. doi:10.1016/j.humimm.2004.07.002. PMID 15603868.
  • Zhu C, Anderson AC, Schubart A; et al. (2006). "The Tim-3 ligand galectin-9 negatively regulates T helper type 1 immunity". Nat. Immunol. 6 (12): 1245–52. doi:10.1038/ni1271. PMID 16286920.
  • Sui L, Zhang W, Chen Y; et al. (2006). "Human membrane protein Tim-3 facilitates hepatitis A virus entry into target cells". Int. J. Mol. Med. 17 (6): 1093–9. PMID 16685421.
  • Koguchi K, Anderson DE, Yang L; et al. (2006). "Dysregulated T cell expression of TIM3 in multiple sclerosis". J. Exp. Med. 203 (6): 1413–8. doi:10.1084/jem.20060210. PMID 16754722.
  • van de Weyer PS, Muehlfeit M, Klose C; et al. (2007). "A highly conserved tyrosine of Tim-3 is phosphorylated upon stimulation by its ligand galectin-9". Biochem. Biophys. Res. Commun. 351 (2): 571–6. doi:10.1016/j.bbrc.2006.10.079. PMID 17069754.
  • Wiener Z, Kohalmi B, Pocza P; et al. (2007). "TIM-3 is expressed in melanoma cells and is upregulated in TGF-beta stimulated mast cells". J. Invest. Dermatol. 127 (4): 906–14. doi:10.1038/sj.jid.5700616. PMID 17096021.
  • Renesto PG, Ponciano VC, Cenedeze MA; et al. (2007). "High expression of Tim-3 mRNA in urinary cells from kidney transplant recipients with acute rejection". Am. J. Transplant. 7 (6): 1661–5. doi:10.1111/j.1600-6143.2007.01795.x. PMID 17430399.
  • Anderson AC, Anderson DE, Bregoli L; et al. (2007). "Promotion of tissue inflammation by the immune receptor Tim-3 expressed on innate immune cells". Science. 318 (5853): 1141–3. doi:10.1126/science.1148536. PMID 18006747.

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