HAX1

HCLS1 associated protein X-1
Identifiers
Symbols	HAX1 ; HCLSBP1; HS1BP1
External IDs	Template:OMIM5 Template:MGI HomoloGene: 4463
Gene ontology Molecular function Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

HCLS1 associated protein X-1, also known as HAX1, is a human gene.

The protein encoded by this gene is known to associate with HS1, a substrate of Src family tyrosine kinases. It also interacts with the product of PKD2 gene, mutations in which are associated with autosomal-dominant polycystic kidney disease, and with F-actin-binding protein, cortactin. It was earlier thought that this gene product is mainly localized in the mitochondria, however, recent studies indicate it to be localized in the cell body. Two transcript variants encoding different isoforms have been found for this gene.

Further reading

• Modem S, Reddy TR (2007). "An anti-apoptotic protein, Hax-1, inhibits the HIV-1 rev function by altering its sub-cellular localization". J. Cell. Physiol. 214 (1): 14–9. doi:10.1002/jcp.21305. PMID 17929250.
• Klein C, Grudzien M, Appaswamy G; et al. (2007). "HAX1 deficiency causes autosomal recessive severe congenital neutropenia (Kostmann disease)". Nat. Genet. 39 (1): 86–92. doi:10.1038/ng1940. PMID 17187068.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kawaguchi Y, Nishimagi E, Tochimoto A; et al. (2006). "Intracellular IL-1alpha-binding proteins contribute to biological functions of endogenous IL-1alpha in systemic sclerosis fibroblasts". Proc. Natl. Acad. Sci. U.S.A. 103 (39): 14501–6. doi:10.1073/pnas.0603545103. PMID 16971486.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Han Y, Chen YS, Liu Z; et al. (2006). "Overexpression of HAX-1 protects cardiac myocytes from apoptosis through caspase-9 inhibition". Circ. Res. 99 (4): 415–23. doi:10.1161/01.RES.0000237387.05259.a5. PMID 16857965.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Rual JF, Venkatesan K, Hao T; et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ortiz DF, Moseley J, Calderon G; et al. (2004). "Identification of HAX-1 as a protein that binds bile salt export protein and regulates its abundance in the apical membrane of Madin-Darby canine kidney cells". J. Biol. Chem. 279 (31): 32761–70. doi:10.1074/jbc.M404337200. PMID 15159385.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Bouwmeester T, Bauch A, Ruffner H; et al. (2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway". Nat. Cell Biol. 6 (2): 97–105. doi:10.1038/ncb1086. PMID 14743216.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Mirmohammadsadegh A, Tartler U, Michel G; et al. (2003). "HAX-1, identified by differential display reverse transcription polymerase chain reaction, is overexpressed in lesional psoriasis". J. Invest. Dermatol. 120 (6): 1045–51. doi:10.1046/j.1523-1747.2003.12247.x. PMID 12787133.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Yin H, Morioka H, Towle CA; et al. (2001). "Evidence that HAX-1 is an interleukin-1 alpha N-terminal binding protein". Cytokine. 15 (3): 122–37. doi:10.1006/cyto.2001.0891. PMID 11554782.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gallagher AR, Cedzich A, Gretz N; et al. (2000). "The polycystic kidney disease protein PKD2 interacts with Hax-1, a protein associated with the actin cytoskeleton". Proc. Natl. Acad. Sci. U.S.A. 97 (8): 4017–22. PMID 10760273.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Suzuki Y, Demoliere C, Kitamura D; et al. (1997). "HAX-1, a novel intracellular protein, localized on mitochondria, directly associates with HS1, a substrate of Src family tyrosine kinases". J. Immunol. 158 (6): 2736–44. PMID 9058808.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)