HBXIP

Hepatitis B virus x interacting protein
Identifiers
Symbols	HBXIP ; MGC71071; XIP
External IDs	Template:OMIM5 Template:MGI HomoloGene: 4668
Gene ontology Molecular function Template:GNF GO Cellular component Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Hepatitis B virus x interacting protein, also known as HBXIP, is a human gene.

This gene encodes a protein that specifically complexes with the C-terminus of hepatitis B virus X protein (HBx). The function of this protein is to negatively regulate HBx activity and thus to alter the replication life cycle of the virus.

Further reading

• Melegari M, Scaglioni PP, Wands JR (1998). "Cloning and characterization of a novel hepatitis B virus x binding protein that inhibits viral replication". J. Virol. 72 (3): 1737–43. PMID 9499022.CS1 maint: Multiple names: authors list (link)
• Shamay M, Barak O, Doitsh G; et al. (2002). "Hepatitis B virus pX interacts with HBXAP, a PHD finger protein to coactivate transcription". J. Biol. Chem. 277 (12): 9982–8. doi:10.1074/jbc.M111354200. PMID 11788598.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Li Y, Lu YY (2002). "Applying a highly specific and reproducible cDNA RDA method to clone garlic up-regulated genes in human gastric cancer cells". World J. Gastroenterol. 8 (2): 213–6. PMID 11925594.
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Marusawa H, Matsuzawa S, Welsh K; et al. (2003). "HBXIP functions as a cofactor of survivin in apoptosis suppression". EMBO J. 22 (11): 2729–40. doi:10.1093/emboj/cdg263. PMID 12773388.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kong HJ, Park MJ, Hong S; et al. (2003). "Hepatitis B virus X protein regulates transactivation activity and protein stability of the cancer-amplified transcription coactivator ASC-2". Hepatology. 38 (5): 1258–66. doi:10.1053/jhep.2003.50451. PMID 14578865.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Lee SH, Park SG, Lim SO, Jung G (2005). "The hepatitis B virus X protein up-regulates lymphotoxin alpha expression in hepatocytes". Biochim. Biophys. Acta. 1741 (1–2): 75–84. doi:10.1016/j.bbadis.2004.10.004. PMID 15955450.CS1 maint: Multiple names: authors list (link)
• Lee AT, Ren J, Wong ET; et al. (2005). "The hepatitis B virus X protein sensitizes HepG2 cells to UV light-induced DNA damage". J. Biol. Chem. 280 (39): 33525–35. doi:10.1074/jbc.M506628200. PMID 16055925.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Stelzl U, Worm U, Lalowski M; et al. (2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell. 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. PMID 16169070.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Minczuk M, Mroczek S, Pawlak SD, Stepien PP (2005). "Human ATP-dependent RNA/DNA helicase hSuv3p interacts with the cofactor of survivin HBXIP". FEBS J. 272 (19): 5008–19. doi:10.1111/j.1742-4658.2005.04910.x. PMID 16176273.CS1 maint: Multiple names: authors list (link)
• Muroyama R, Kato N, Yoshida H; et al. (2007). "Nucleotide change of codon 38 in the X gene of hepatitis B virus genotype C is associated with an increased risk of hepatocellular carcinoma". J. Hepatol. 45 (6): 805–12. doi:10.1016/j.jhep.2006.07.025. PMID 17050029.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Chen J, Siddiqui A (2007). "Hepatitis B virus X protein stimulates the mitochondrial translocation of Raf-1 via oxidative stress". J. Virol. 81 (12): 6757–60. doi:10.1128/JVI.00172-07. PMID 17428866.