HGS (gene)

Hepatocyte growth factor-regulated tyrosine kinase substrate
Identifiers
Symbols	HGS ; HRS; ZFYVE8
External IDs	Template:OMIM5 Template:MGI HomoloGene: 37954
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Hepatocyte growth factor-regulated tyrosine kinase substrate, also known as HGS, is a human gene.

Further reading

• Comoglio PM (1993). "Structure, biosynthesis and biochemical properties of the HGF receptor in normal and malignant cells". EXS. 65: 131–65. PMID 8380735.
• Komada M, Masaki R, Yamamoto A, Kitamura N (1997). "Hrs, a tyrosine kinase substrate with a conserved double zinc finger domain, is localized to the cytoplasmic surface of early endosomes". J. Biol. Chem. 272 (33): 20538–44. PMID 9252367.CS1 maint: Multiple names: authors list (link)
• Asao H, Sasaki Y, Arita T; et al. (1998). "Hrs is associated with STAM, a signal-transducing adaptor molecule. Its suppressive effect on cytokine-induced cell growth". J. Biol. Chem. 272 (52): 32785–91. PMID 9407053.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Lu L, Komada M, Kitamura N (1998). "Human Hrs, a tyrosine kinase substrate in growth factor-stimulated cells: cDNA cloning and mapping of the gene to chromosome 17". Gene. 213 (1–2): 125–32. PMID 9630564.CS1 maint: Multiple names: authors list (link)
• Stephens DJ, Banting G (1999). "Direct interaction of the trans-Golgi network membrane protein, TGN38, with the F-actin binding protein, neurabin". J. Biol. Chem. 274 (42): 30080–6. PMID 10514494.
• Bean AJ, Davanger S, Chou MF; et al. (2000). "Hrs-2 regulates receptor-mediated endocytosis via interactions with Eps15". J. Biol. Chem. 275 (20): 15271–8. PMID 10809762.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kwong J, Roundabush FL, Hutton Moore P; et al. (2000). "Hrs interacts with SNAP-25 and regulates Ca(2+)-dependent exocytosis". J. Cell. Sci. 113 ( Pt 12): 2273–84. PMID 10825299.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Scoles DR, Huynh DP, Chen MS; et al. (2000). "The neurofibromatosis 2 tumor suppressor protein interacts with hepatocyte growth factor-regulated tyrosine kinase substrate". Hum. Mol. Genet. 9 (11): 1567–74. PMID 10861283.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gillooly DJ, Morrow IC, Lindsay M; et al. (2000). "Localization of phosphatidylinositol 3-phosphate in yeast and mammalian cells". EMBO J. 19 (17): 4577–88. doi:10.1093/emboj/19.17.4577. PMID 10970851.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Miura S, Takeshita T, Asao H; et al. (2001). "Hgs (Hrs), a FYVE domain protein, is involved in Smad signaling through cooperation with SARA". Mol. Cell. Biol. 20 (24): 9346–55. PMID 11094085.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Chin LS, Raynor MC, Wei X; et al. (2001). "Hrs interacts with sorting nexin 1 and regulates degradation of epidermal growth factor receptor". J. Biol. Chem. 276 (10): 7069–78. doi:10.1074/jbc.M004129200. PMID 11110793.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gutmann DH, Haipek CA, Burke SP; et al. (2001). "The NF2 interactor, hepatocyte growth factor-regulated tyrosine kinase substrate (HRS), associates with merlin in the "open" conformation and suppresses cell growth and motility". Hum. Mol. Genet. 10 (8): 825–34. PMID 11285248.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Sasaki Y, Sugamura K (2001). "Involvement of Hgs/Hrs in signaling for cytokine-mediated c-fos induction through interaction with TAK1 and Pak1". J. Biol. Chem. 276 (32): 29943–52. doi:10.1074/jbc.M104230200. PMID 11397816.
• Raiborg C, Bremnes B, Mehlum A; et al. (2001). "FYVE and coiled-coil domains determine the specific localisation of Hrs to early endosomes". J. Cell. Sci. 114 (Pt 12): 2255–63. PMID 11493665.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Raiborg C, Bache KG, Mehlum A; et al. (2001). "Hrs recruits clathrin to early endosomes". EMBO J. 20 (17): 5008–21. doi:10.1093/emboj/20.17.5008. PMID 11532964.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Steen H, Kuster B, Fernandez M; et al. (2002). "Tyrosine phosphorylation mapping of the epidermal growth factor receptor signaling pathway". J. Biol. Chem. 277 (2): 1031–9. doi:10.1074/jbc.M109992200. PMID 11687594.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Bishop N, Horman A, Woodman P (2002). "Mammalian class E vps proteins recognize ubiquitin and act in the removal of endosomal protein-ubiquitin conjugates". J. Cell Biol. 157 (1): 91–101. doi:10.1083/jcb.200112080. PMID 11916981.CS1 maint: Multiple names: authors list (link)
• Tchernev VT, Mansfield TA, Giot L; et al. (2002). "The Chediak-Higashi protein interacts with SNARE complex and signal transduction proteins". Mol. Med. 8 (1): 56–64. PMID 11984006.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Li Y, Chin LS, Levey AI, Li L (2002). "Huntingtin-associated protein 1 interacts with hepatocyte growth factor-regulated tyrosine kinase substrate and functions in endosomal trafficking". J. Biol. Chem. 277 (31): 28212–21. doi:10.1074/jbc.M111612200. PMID 12021262.CS1 maint: Multiple names: authors list (link)