HIP2

Huntingtin interacting protein 2
PDB rendering based on 1yla.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 1yla​, 2bep​, 2bf8​, 2o25​
Identifiers
Symbols	HIP2 ; HYPG; LIG; UBE2K
External IDs	Template:OMIM5 Template:MGI HomoloGene: 3903
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Huntingtin interacting protein 2, also known as HIP2, is a human gene.

The protein encoded by this gene belongs to the ubiquitin-conjugating enzyme family. It binds selectively to a large region at the N terminus of huntingtin. This interaction is not influenced by the length of the huntingtin polyglutamine tract. This protein has been implicated in the degradation of huntingtin and suppression of apoptosis.

Further reading

• Petersén A, Mani K, Brundin P (1999). "Recent advances on the pathogenesis of Huntington's disease". Exp. Neurol. 157 (1): 1–18. doi:10.1006/exnr.1998.7006. PMID 10222105.CS1 maint: Multiple names: authors list (link)
• Kalchman MA, Graham RK, Xia G; et al. (1996). "Huntingtin is ubiquitinated and interacts with a specific ubiquitin-conjugating enzyme". J. Biol. Chem. 271 (32): 19385–94. PMID 8702625.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Coux O, Goldberg AL (1998). "Enzymes catalyzing ubiquitination and proteolytic processing of the p105 precursor of nuclear factor kappaB1". J. Biol. Chem. 273 (15): 8820–8. PMID 9535861.
• Whitby FG, Xia G, Pickart CM, Hill CP (1999). "Crystal structure of the human ubiquitin-like protein NEDD8 and interactions with ubiquitin pathway enzymes". J. Biol. Chem. 273 (52): 34983–91. PMID 9857030.CS1 maint: Multiple names: authors list (link)
• Kikuchi J, Furukawa Y, Kubo N; et al. (2000). "Induction of ubiquitin-conjugating enzyme by aggregated low density lipoprotein in human macrophages and its implications for atherosclerosis". Arterioscler. Thromb. Vasc. Biol. 20 (1): 128–34. PMID 10634809.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Furukawa Y, Kubo N, Kikuchi J; et al. (2000). "Regulation of macrophage-specific gene expression by degenerated lipoproteins". Electrophoresis. 21 (2): 338–46. doi:10.1002/(SICI)1522-2683(20000101)21:2<338::AID-ELPS338>3.0.CO;2-9. PMID 10675012.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Lee SJ, Choi JY, Sung YM; et al. (2001). "E3 ligase activity of RING finger proteins that interact with Hip-2, a human ubiquitin-conjugating enzyme". FEBS Lett. 503 (1): 61–4. PMID 11513855.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gevaert K, Goethals M, Martens L; et al. (2004). "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides". Nat. Biotechnol. 21 (5): 566–9. doi:10.1038/nbt810. PMID 12665801.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Goehler H, Lalowski M, Stelzl U; et al. (2004). "A protein interaction network links GIT1, an enhancer of huntingtin aggregation, to Huntington's disease". Mol. Cell. 15 (6): 853–65. doi:10.1016/j.molcel.2004.09.016. PMID 15383276.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kimura K, Wakamatsu A, Suzuki Y; et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMID 16344560.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Flierman D, Coleman CS, Pickart CM; et al. (2006). "E2-25K mediates US11-triggered retro-translocation of MHC class I heavy chains in a permeabilized cell system". Proc. Natl. Acad. Sci. U.S.A. 103 (31): 11589–94. doi:10.1073/pnas.0605215103. PMID 16868077.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• de Pril R, Fischer DF, Roos RA, van Leeuwen FW (2007). "Ubiquitin-conjugating enzyme E2-25K increases aggregate formation and cell death in polyglutamine diseases". Mol. Cell. Neurosci. 34 (1): 10–9. doi:10.1016/j.mcn.2006.09.006. PMID 17092742.CS1 maint: Multiple names: authors list (link)
• Ewing RM, Chu P, Elisma F; et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3: 89. doi:10.1038/msb4100134. PMID 17353931.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Christensen DE, Brzovic PS, Klevit RE. "E2-BRCA1 RING interactions dictate synthesis of mono- or specific polyubiquitin chain linkages". Nat. Struct. Mol. Biol. 14 (10): 941–8. doi:10.1038/nsmb1295. PMID 17873885.CS1 maint: Multiple names: authors list (link)