HRB (gene)

HIV-1 Rev binding protein
PDB rendering based on 2d9l.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 2d9l​, 2olm​
Identifiers
Symbols	HRB ; MGC116938; MGC116940; RAB; RIP
External IDs	Template:OMIM5 Template:MGI HomoloGene: 37929
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

HIV-1 Rev binding protein, also known as HRB, is a human gene.

The protein encoded by this gene is related to nucleoporins, a class of proteins that mediate nucleocytoplasmic transport. This encoded protein binds the Rev activation domain when Rev is assembled onto its RNA target and can significantly enhance Rev activity when overexpressed. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined.

Further reading

• Li L, Li HS, Pauza CD; et al. (2006). "Roles of HIV-1 auxiliary proteins in viral pathogenesis and host-pathogen interactions". Cell Res. 15 (11–12): 923–34. doi:10.1038/sj.cr.7290370. PMID 16354571.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Bogerd HP, Fridell RA, Madore S, Cullen BR (1995). "Identification of a novel cellular cofactor for the Rev/Rex class of retroviral regulatory proteins". Cell. 82 (3): 485–94. PMID 7634337.CS1 maint: Multiple names: authors list (link)
• Fritz CC, Zapp ML, Green MR (1995). "A human nucleoporin-like protein that specifically interacts with HIV Rev". Nature. 376 (6540): 530–3. doi:10.1038/376530a0. PMID 7637788.CS1 maint: Multiple names: authors list (link)
• Fridell RA, Bogerd HP, Cullen BR (1996). "Nuclear export of late HIV-1 mRNAs occurs via a cellular protein export pathway". Proc. Natl. Acad. Sci. U.S.A. 93 (9): 4421–4. PMID 8633082.CS1 maint: Multiple names: authors list (link)
• Fritz CC, Green MR (1997). "HIV Rev uses a conserved cellular protein export pathway for the nucleocytoplasmic transport of viral RNAs". Curr. Biol. 6 (7): 848–54. PMID 8805303.
• Stutz F, Izaurralde E, Mattaj IW, Rosbash M (1997). "A role for nucleoporin FG repeat domains in export of human immunodeficiency virus type 1 Rev protein and RNA from the nucleus". Mol. Cell. Biol. 16 (12): 7144–50. PMID 8943370.CS1 maint: Multiple names: authors list (link)
• Jones T, Sheer D, Bevec D; et al. (1997). "The human HIV-1 Rev binding-protein hRIP/Rab (HRB) maps to chromosome 2q36". Genomics. 40 (1): 198–9. doi:10.1006/geno.1996.4457. PMID 9070945.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Salcini AE, Confalonieri S, Doria M; et al. (1997). "Binding specificity and in vivo targets of the EH domain, a novel protein-protein interaction module". Genes Dev. 11 (17): 2239–49. PMID 9303539.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Neville M, Stutz F, Lee L; et al. (1998). "The importin-beta family member Crm1p bridges the interaction between Rev and the nuclear pore complex during nuclear export". Curr. Biol. 7 (10): 767–75. PMID 9368759.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Güre AO, Altorki NK, Stockert E; et al. (1998). "Human lung cancer antigens recognized by autologous antibodies: definition of a novel cDNA derived from the tumor suppressor gene locus on chromosome 3p21.3". Cancer Res. 58 (5): 1034–41. PMID 9500467.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Farjot G, Sergeant A, Mikaélian I (1999). "A new nucleoporin-like protein interacts with both HIV-1 Rev nuclear export signal and CRM-1". J. Biol. Chem. 274 (24): 17309–17. PMID 10358091.CS1 maint: Multiple names: authors list (link)
• Doria M, Salcini AE, Colombo E; et al. (2000). "The eps15 homology (EH) domain-based interaction between eps15 and hrb connects the molecular machinery of endocytosis to that of nucleocytosolic transport". J. Cell Biol. 147 (7): 1379–84. PMID 10613896.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Dias Neto E, Correa RG, Verjovski-Almeida S; et al. (2000). "Shotgun sequencing of the human transcriptome with ORF expressed sequence tags". Proc. Natl. Acad. Sci. U.S.A. 97 (7): 3491–6. PMID 10737800.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Yang J, Bogerd HP, Wang PJ; et al. (2001). "Two closely related human nuclear export factors utilize entirely distinct export pathways". Mol. Cell. 8 (2): 397–406. PMID 11545741.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Chen D, Li X, Zhai Z, Shu HB (2002). "A novel zinc finger protein interacts with receptor-interacting protein (RIP) and inhibits tumor necrosis factor (TNF)- and IL1-induced NF-kappa B activation". J. Biol. Chem. 277 (18): 15985–91. doi:10.1074/jbc.M108675200. PMID 11854271.CS1 maint: Multiple names: authors list (link)
• Scherl A, Couté Y, Déon C; et al. (2003). "Functional proteomic analysis of human nucleolus". Mol. Biol. Cell. 13 (11): 4100–9. doi:10.1091/mbc.E02-05-0271. PMID 12429849.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kiss A, Li L, Gettemeier T, Venkatesh LK (2003). "Functional analysis of the interaction of the human immunodeficiency virus type 1 Rev nuclear export signal with its cofactors". Virology. 314 (2): 591–600. PMID 14554087.CS1 maint: Multiple names: authors list (link)
• Sánchez-Velar N, Udofia EB, Yu Z, Zapp ML (2004). "hRIP, a cellular cofactor for Rev function, promotes release of HIV RNAs from the perinuclear region". Genes Dev. 18 (1): 23–34. doi:10.1101/gad.1149704. PMID 14701878.CS1 maint: Multiple names: authors list (link)
• Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)