HYAL1

Hyaluronoglucosaminidase 1
Identifiers
Symbols	HYAL1 ; HYAL-1; LUCA1; MGC45987; NAT6
External IDs	Template:OMIM5 Template:MGI HomoloGene: 5277
Gene ontology Molecular function Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO
RNA expression pattern
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Hyaluronoglucosaminidase 1, also known as HYAL1, is a human gene.

This gene encodes a lysosomal hyaluronidase. Hyaluronidases intracellularly degrade hyaluronan, one of the major glycosaminoglycans of the extracellular matrix. Hyaluronan is thought to be involved in cell proliferation, migration and differentiation. This enzyme is active at an acidic pH and is the major hyaluronidase in plasma. Mutations in this gene are associated with mucopolysaccharidosis type IX, or hyaluronidase deficiency. The gene is one of several related genes in a region of chromosome 3p21.3 associated with tumor suppression. Multiple transcript variants encoding different isoforms have been found for this gene.

Further reading

• Wei MH, Latif F, Bader S; et al. (1996). "Construction of a 600-kilobase cosmid clone contig and generation of a transcriptional map surrounding the lung cancer tumor suppressor gene (TSG) locus on human chromosome 3p21.3: progress toward the isolation of a lung cancer TSG". Cancer Res. 56 (7): 1487–92. PMID 8603390.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Natowicz MR, Short MP, Wang Y; et al. (1996). "Clinical and biochemical manifestations of hyaluronidase deficiency". N. Engl. J. Med. 335 (14): 1029–33. PMID 8793927.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Frost GI, Csóka AB, Wong T; et al. (1997). "Purification, cloning, and expression of human plasma hyaluronidase". Biochem. Biophys. Res. Commun. 236 (1): 10–5. PMID 9223416.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Csóka AB, Frost GI, Wong T; et al. (1998). "Purification and microsequencing of hyaluronidase isozymes from human urine". FEBS Lett. 417 (3): 307–10. PMID 9409739.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Csóka AB, Frost GI, Heng HH; et al. (1998). "The hyaluronidase gene HYAL1 maps to chromosome 3p21.2-p21.3 in human and 9F1-F2 in mouse, a conserved candidate tumor suppressor locus". Genomics. 48 (1): 63–70. PMID 9503017.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Triggs-Raine B, Salo TJ, Zhang H; et al. (1999). "Mutations in HYAL1, a member of a tandemly distributed multigene family encoding disparate hyaluronidase activities, cause a newly described lysosomal disorder, mucopolysaccharidosis IX". Proc. Natl. Acad. Sci. U.S.A. 96 (11): 6296–300. PMID 10339581.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Frost GI, Mohapatra G, Wong TM; et al. (2000). "HYAL1LUCA-1, a candidate tumor suppressor gene on chromosome 3p21.3, is inactivated in head and neck squamous cell carcinomas by aberrant splicing of pre-mRNA". Oncogene. 19 (7): 870–7. doi:10.1038/sj.onc.1203317. PMID 10702795.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Shuttleworth TL, Wilson MD, Wicklow BA; et al. (2002). "Characterization of the murine hyaluronidase gene region reveals complex organization and cotranscription of Hyal1 with downstream genes, Fus2 and Hyal3". J. Biol. Chem. 277 (25): 23008–18. doi:10.1074/jbc.M108991200. PMID 11929860.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Lokeshwar VB, Schroeder GL, Carey RI; et al. (2002). "Regulation of hyaluronidase activity by alternative mRNA splicing". J. Biol. Chem. 277 (37): 33654–63. doi:10.1074/jbc.M203821200. PMID 12084718.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Junker N, Latini S, Petersen LN, Kristjansen PE (2003). "Expression and regulation patterns of hyaluronidases in small cell lung cancer and glioma lines". Oncol. Rep. 10 (3): 609–16. PMID 12684632.CS1 maint: Multiple names: authors list (link)
• Franzmann EJ, Schroeder GL, Goodwin WJ; et al. (2003). "Expression of tumor markers hyaluronic acid and hyaluronidase (HYAL1) in head and neck tumors". Int. J. Cancer. 106 (3): 438–45. doi:10.1002/ijc.11252. PMID 12845686.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Muzny DM, Scherer SE, Kaul R; et al. (2006). "The DNA sequence, annotation and analysis of human chromosome 3". Nature. 440 (7088): 1194–8. doi:10.1038/nature04728. PMID 16641997.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Christopoulos TA, Papageorgakopoulou N, Theocharis DA; et al. (2006). "Hyaluronidase and CD44 hyaluronan receptor expression in squamous cell laryngeal carcinoma". Biochim. Biophys. Acta. 1760 (7): 1039–45. doi:10.1016/j.bbagen.2006.03.019. PMID 16713680.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Lokeshwar VB, Estrella V, Lopez L; et al. (2007). "HYAL1-v1, an alternatively spliced variant of HYAL1 hyaluronidase: a negative regulator of bladder cancer". Cancer Res. 66 (23): 11219–27. doi:10.1158/0008-5472.CAN-06-1121. PMID 17145867.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Hofinger ES, Spickenreither M, Oschmann J; et al. (2007). "Recombinant human hyaluronidase Hyal-1: insect cells versus Escherichia coli as expression system and identification of low molecular weight inhibitors". Glycobiology. 17 (4): 444–53. doi:10.1093/glycob/cwm003. PMID 17227790.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Nieuwdorp M, Holleman F, de Groot E; et al. (2007). "Perturbation of hyaluronan metabolism predisposes patients with type 1 diabetes mellitus to atherosclerosis". Diabetologia. 50 (6): 1288–93. doi:10.1007/s00125-007-0666-4. PMID 17415544.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Bharadwaj AG, Rector K, Simpson MA (2007). "Inducible hyaluronan production reveals differential effects on prostate tumor cell growth and tumor angiogenesis". J. Biol. Chem. 282 (28): 20561–72. doi:10.1074/jbc.M702964200. PMID 17502371.CS1 maint: Multiple names: authors list (link)