Host cell factor C1

Host cell factor C1 (VP16-accessory protein)
Identifiers
Symbols	HCFC1 ; CFF; HCF-1; HCF1; HFC1; MGC70925; VCAF
External IDs	Template:OMIM5 Template:MGI HomoloGene: 3898
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Host cell factor C1 (VP16-accessory protein), also known as HCFC1, is a human gene.

This gene is a member of the host cell factor family and encodes a protein with five Kelch repeats, a fibronectin-like motif, and six HCF repeats, each of which contains a highly specific cleavage signal. This nuclear coactivator is proteolytically cleaved at one of the six possible sites, resulting in the creation of an N-terminal chain and the corresponding C-terminal chain. The final form of this protein consists of noncovalently bound N- and C-terminal chains. The protein is involved in control of the cell cycle and transcriptional regulation during herpes simplex virus infection. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized.

Further reading

• Oehler T, Angel P (1992). "A common intermediary factor (p52/54) recognizing "acidic blob"-type domains is required for transcriptional activation by the Jun proteins". Mol. Cell. Biol. 12 (12): 5508–15. PMID 1448082.
• Wilson AC, Peterson MG, Herr W (1995). "The HCF repeat is an unusual proteolytic cleavage signal". Genes Dev. 9 (20): 2445–58. PMID 7590226.CS1 maint: Multiple names: authors list (link)
• Klemm RD, Goodrich JA, Zhou S, Tjian R (1995). "Molecular cloning and expression of the 32-kDa subunit of human TFIID reveals interactions with VP16 and TFIIB that mediate transcriptional activation". Proc. Natl. Acad. Sci. U.S.A. 92 (13): 5788–92. PMID 7597030.CS1 maint: Multiple names: authors list (link)
• Frattini A, Faranda S, Redolfi E; et al. (1995). "Genomic organization of the human VP16 accessory protein, a housekeeping gene (HCFC1) mapping to Xq28". Genomics. 23 (1): 30–5. doi:10.1006/geno.1994.1455. PMID 7829097.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kristie TM, Pomerantz JL, Twomey TC; et al. (1995). "The cellular C1 factor of the herpes simplex virus enhancer complex is a family of polypeptides". J. Biol. Chem. 270 (9): 4387–94. PMID 7876203.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Wilson AC, LaMarco K, Peterson MG, Herr W (1993). "The VP16 accessory protein HCF is a family of polypeptides processed from a large precursor protein". Cell. 74 (1): 115–25. PMID 8392914.CS1 maint: Multiple names: authors list (link)
• Kristie TM, Sharp PA (1993). "Purification of the cellular C1 factor required for the stable recognition of the Oct-1 homeodomain by the herpes simplex virus alpha-trans-induction factor (VP16)". J. Biol. Chem. 268 (9): 6525–34. PMID 8454622.
• Zoppè M, Frattini A, Faranda S, Vezzoni P (1996). "The complete sequence of the host cell factor 1 (HCFC1) gene and its promoter: a role for YY1 transcription factor in the regulation of its expression". Genomics. 34 (1): 85–91. doi:10.1006/geno.1996.0244. PMID 8661027.CS1 maint: Multiple names: authors list (link)
• Wilson AC, Freiman RN, Goto H; et al. (1997). "VP16 targets an amino-terminal domain of HCF involved in cell cycle progression". Mol. Cell. Biol. 17 (10): 6139–46. PMID 9315674.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Freiman RN, Herr W (1998). "Viral mimicry: common mode of association with HCF by VP16 and the cellular protein LZIP". Genes Dev. 11 (23): 3122–7. PMID 9389645.
• Lu R, Yang P, Padmakumar S, Misra V (1998). "The herpesvirus transactivator VP16 mimics a human basic domain leucine zipper protein, luman, in its interaction with HCF". J. Virol. 72 (8): 6291–7. PMID 9658067.CS1 maint: Multiple names: authors list (link)
• Ge H, Si Y, Roeder RG (1999). "Isolation of cDNAs encoding novel transcription coactivators p52 and p75 reveals an alternate regulatory mechanism of transcriptional activation". EMBO J. 17 (22): 6723–9. doi:10.1093/emboj/17.22.6723. PMID 9822615.CS1 maint: Multiple names: authors list (link)
• La Boissière S, Hughes T, O'Hare P (1999). "HCF-dependent nuclear import of VP16". EMBO J. 18 (2): 480–9. doi:10.1093/emboj/18.2.480. PMID 9889203.CS1 maint: Multiple names: authors list (link)
• Lu R, Misra V (2000). "Potential role for luman, the cellular homologue of herpes simplex virus VP16 (alpha gene trans-inducing factor), in herpesvirus latency". J. Virol. 74 (2): 934–43. PMID 10623756.
• Mahajan SS, Wilson AC (2000). "Mutations in host cell factor 1 separate its role in cell proliferation from recruitment of VP16 and LZIP". Mol. Cell. Biol. 20 (3): 919–28. PMID 10629049.
• Ajuh PM, Browne GJ, Hawkes NA; et al. (2000). "Association of a protein phosphatase 1 activity with the human factor C1 (HCF) complex". Nucleic Acids Res. 28 (3): 678–86. PMID 10637318.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Vogel JL, Kristie TM (2000). "The novel coactivator C1 (HCF) coordinates multiprotein enhancer formation and mediates transcription activation by GABP". EMBO J. 19 (4): 683–90. doi:10.1093/emboj/19.4.683. PMID 10675337.
• Scarr RB, Smith MR, Beddall M, Sharp PA (2000). "A novel 50-kilodalton fragment of host cell factor 1 (C1) in G(0) cells". Mol. Cell. Biol. 20 (10): 3568–75. PMID 10779346.CS1 maint: Multiple names: authors list (link)
• Choi Y, Asada S, Uesugi M (2000). "Divergent hTAFII31-binding motifs hidden in activation domains". J. Biol. Chem. 275 (21): 15912–6. PMID 10821850.CS1 maint: Multiple names: authors list (link)
• Lu R, Misra V (2000). "Zhangfei: a second cellular protein interacts with herpes simplex virus accessory factor HCF in a manner similar to Luman and VP16". Nucleic Acids Res. 28 (12): 2446–54. PMID 10871379.