IGFBP1

Insulin-like growth factor binding protein 1
PDB rendering based on 1zt3.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 1zt3​, 1zt5​, 2dsq​
Identifiers
Symbols	IGFBP1 ; IBP1; AFBP; IGF-BP25; PP12; hIGFBP-1
External IDs	Template:OMIM5 Template:MGI HomoloGene: 498
Gene ontology Molecular function Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO
RNA expression pattern
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Insulin-like growth factor binding protein 1, also known as IGFBP1, is a human gene.

This gene is a member of the insulin-like growth factor binding protein (IGFBP) family and encodes a protein with an IGFBP domain and a thyroglobulin type-I domain. The protein binds both insulin-like growth factors (IGFs) I and II and circulates in the plasma. Binding of this protein prolongs the half-life of the IGFs and alters their interaction with cell surface receptors. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.

Further reading

• Rajaram S, Baylink DJ, Mohan S (1998). "Insulin-like growth factor-binding proteins in serum and other biological fluids: regulation and functions". Endocr. Rev. 18 (6): 801–31. PMID 9408744.CS1 maint: Multiple names: authors list (link)
• Ferry RJ, Cerri RW, Cohen P (1999). "Insulin-like growth factor binding proteins: new proteins, new functions". Horm. Res. 51 (2): 53–67. PMID 10352394.CS1 maint: Multiple names: authors list (link)
• Firth SM, Baxter RC (2003). "Cellular actions of the insulin-like growth factor binding proteins". Endocr. Rev. 23 (6): 824–54. PMID 12466191.
• Wood AW, Duan C, Bern HA (2005). "Insulin-like growth factor signaling in fish". Int. Rev. Cytol. 243: 215–85. doi:10.1016/S0074-7696(05)43004-1. PMID 15797461.CS1 maint: Multiple names: authors list (link)
• Ehrenborg E, Larsson C, Stern I; et al. (1992). "Contiguous localization of the genes encoding human insulin-like growth factor binding proteins 1 (IGBP1) and 3 (IGBP3) on chromosome 7". Genomics. 12 (3): 497–502. PMID 1373120.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ekstrand J, Ehrenborg E, Stern I; et al. (1990). "The gene for insulin-like growth factor-binding protein-1 is localized to human chromosomal region 7p14-p12". Genomics. 6 (3): 413–8. PMID 1691735.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Suwanichkul A, Cubbage ML, Powell DR (1991). "The promoter of the human gene for insulin-like growth factor binding protein-1. Basal promoter activity in HEP G2 cells depends upon liver factor B1". J. Biol. Chem. 265 (34): 21185–93. PMID 1701175.CS1 maint: Multiple names: authors list (link)
• Brinkman A, Kortleve DJ, Schuller AG; et al. (1991). "Site-directed mutagenesis of the N-terminal region of IGF binding protein 1; analysis of IGF binding capability". FEBS Lett. 291 (2): 264–8. PMID 1718783.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Brewer MT, Stetler GL, Squires CH; et al. (1988). "Cloning, characterization, and expression of a human insulin-like growth factor binding protein". Biochem. Biophys. Res. Commun. 152 (3): 1289–97. PMID 2454104.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Julkunen M, Koistinen R, Aalto-Setälä K; et al. (1988). "Primary structure of human insulin-like growth factor-binding protein/placental protein 12 and tissue-specific expression of its mRNA". FEBS Lett. 236 (2): 295–302. PMID 2457513.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Lee YL, Hintz RL, James PM; et al. (1988). "Insulin-like growth factor (IGF) binding protein complementary deoxyribonucleic acid from human HEP G2 hepatoma cells: predicted protein sequence suggests an IGF binding domain different from those of the IGF-I and IGF-II receptors". Mol. Endocrinol. 2 (5): 404–11. PMID 2458522.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Brinkman A, Groffen C, Kortleve DJ; et al. (1989). "Isolation and characterization of a cDNA encoding the low molecular weight insulin-like growth factor binding protein (IBP-1)". EMBO J. 7 (8): 2417–23. PMID 2461294.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Luthman H, Söderling-Barros J, Persson B; et al. (1989). "Human insulin-like growth-factor-binding protein. Low-molecular-mass form: protein sequence and cDNA cloning". Eur. J. Biochem. 180 (2): 259–65. PMID 2466665.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Cubbage ML, Suwanichkul A, Powell DR (1989). "Structure of the human chromosomal gene for the 25 kilodalton insulin-like growth factor binding protein". Mol. Endocrinol. 3 (5): 846–51. PMID 2474129.CS1 maint: Multiple names: authors list (link)
• Alitalo T, Kontula K, Koistinen R; et al. (1989). "The gene encoding human low-molecular weight insulin-like growth-factor binding protein (IGF-BP25): regional localization to 7p12-p13 and description of a DNA polymorphism". Hum. Genet. 83 (4): 335–8. PMID 2478445.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Brinkman A, Groffen CA, Kortleve DJ, Drop SL (1989). "Organization of the gene encoding the insulin-like growth factor binding protein IBP-1". Biochem. Biophys. Res. Commun. 157 (3): 898–907. PMID 2849945.CS1 maint: Multiple names: authors list (link)
• Busby WH, Klapper DG, Clemmons DR (1988). "Purification of a 31,000-dalton insulin-like growth factor binding protein from human amniotic fluid. Isolation of two forms with different biologic actions". J. Biol. Chem. 263 (28): 14203–10. PMID 2971653.CS1 maint: Multiple names: authors list (link)
• Grundmann U, Nerlich C, Bohn H, Rein T (1988). "Cloning of cDNA encoding human placental protein 12 (PP12): binding protein for IGF I and somatomedin". Nucleic Acids Res. 16 (17): 8711. PMID 3419931.CS1 maint: Multiple names: authors list (link)
• Jones JI, Gockerman A, Busby WH; et al. (1993). "Insulin-like growth factor binding protein 1 stimulates cell migration and binds to the alpha 5 beta 1 integrin by means of its Arg-Gly-Asp sequence". Proc. Natl. Acad. Sci. U.S.A. 90 (22): 10553–7. PMID 7504269.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Jones JI, Busby WH, Wright G; et al. (1993). "Identification of the sites of phosphorylation in insulin-like growth factor binding protein-1. Regulation of its affinity by phosphorylation of serine 101". J. Biol. Chem. 268 (2): 1125–31. PMID 7678248.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)