INCENP

Inner centromere protein antigens 135/155kDa
Identifiers
Symbols	INCENP ; FLJ31633; MGC111393
External IDs	Template:OMIM5 Template:MGI HomoloGene: 9624
Gene ontology Molecular function Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Inner centromere protein antigens 135/155kDa, also known as INCENP, is a human gene.

In mammalian cells, 2 broad groups of centromere-interacting proteins have been described: constitutively binding centromere proteins and 'passenger,' or transiently interacting, proteins (reviewed by Choo, 1997). The constitutive proteins include CENPA (centromere protein A; MIM 117139), CENPB (MIM 117140), CENPC1 (MIM 117141), and CENPD (MIM 117142). The term 'passenger proteins' encompasses a broad collection of proteins that localize to the centromere during specific stages of the cell cycle (Earnshaw and Mackay, 1994). These include CENPE (MIM 117143); MCAK (MIM 604538); KID (MIM 603213); cytoplasmic dynein (e.g., MIM 600112); CliPs (e.g., MIM 179838); and CENPF/mitosin (MIM 600236). The inner centromere proteins (INCENPs) (Earnshaw and Cooke, 1991), the initial members of the passenger protein group, display a broad localization along chromosomes in the early stages of mitosis but gradually become concentrated at centromeres as the cell cycle progresses into mid-metaphase. During telophase, the proteins are located within the midbody in the intercellular bridge, where they are discarded after cytokinesis (Cutts et al., 1999).[supplied by OMIM]

Further reading

• Earnshaw WC, Cooke CA (1991). "Analysis of the distribution of the INCENPs throughout mitosis reveals the existence of a pathway of structural changes in the chromosomes during metaphase and early events in cleavage furrow formation". J. Cell. Sci. 98 ( Pt 4): 443–61. PMID 1860899.
• Ainsztein AM, Kandels-Lewis SE, Mackay AM, Earnshaw WC (1999). "INCENP centromere and spindle targeting: identification of essential conserved motifs and involvement of heterochromatin protein HP1". J. Cell Biol. 143 (7): 1763–74. PMID 9864353.CS1 maint: Multiple names: authors list (link)
• Martineau-Thuillier S, Andreassen PR, Margolis RL (1999). "Colocalization of TD-60 and INCENP throughout G2 and mitosis: evidence for their possible interaction in signalling cytokinesis". Chromosoma. 107 (6–7): 461–70. PMID 9914378.CS1 maint: Multiple names: authors list (link)
• Dias Neto E, Correa RG, Verjovski-Almeida S; et al. (2000). "Shotgun sequencing of the human transcriptome with ORF expressed sequence tags". Proc. Natl. Acad. Sci. U.S.A. 97 (7): 3491–6. PMID 10737800.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Wheatley SP, Kandels-Lewis SE, Adams RR; et al. (2001). "INCENP binds directly to tubulin and requires dynamic microtubules to target to the cleavage furrow". Exp. Cell Res. 262 (2): 122–7. doi:10.1006/excr.2000.5088. PMID 11139336.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Adams RR, Eckley DM, Vagnarelli P; et al. (2001). "Human INCENP colocalizes with the Aurora-B/AIRK2 kinase on chromosomes and is overexpressed in tumour cells". Chromosoma. 110 (2): 65–74. PMID 11453556.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Wheatley SP, Carvalho A, Vagnarelli P, Earnshaw WC (2001). "INCENP is required for proper targeting of Survivin to the centromeres and the anaphase spindle during mitosis". Curr. Biol. 11 (11): 886–90. PMID 11516652.CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Parra MT, Viera A, Gómez R; et al. (2003). "Dynamic relocalization of the chromosomal passenger complex proteins inner centromere protein (INCENP) and aurora-B kinase during male mouse meiosis". J. Cell. Sci. 116 (Pt 6): 961–74. PMID 12584241.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Rangasamy D, Berven L, Ridgway P, Tremethick DJ (2003). "Pericentric heterochromatin becomes enriched with H2A.Z during early mammalian development". EMBO J. 22 (7): 1599–607. doi:10.1093/emboj/cdg160. PMID 12660166.CS1 maint: Multiple names: authors list (link)
• Honda R, Körner R, Nigg EA (2004). "Exploring the functional interactions between Aurora B, INCENP, and survivin in mitosis". Mol. Biol. Cell. 14 (8): 3325–41. doi:10.1091/mbc.E02-11-0769. PMID 12925766.CS1 maint: Multiple names: authors list (link)
• Wheatley SP, Henzing AJ, Dodson H; et al. (2004). "Aurora-B phosphorylation in vitro identifies a residue of survivin that is essential for its localization and binding to inner centromere protein (INCENP) in vivo". J. Biol. Chem. 279 (7): 5655–60. doi:10.1074/jbc.M311299200. PMID 14610074.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gassmann R, Carvalho A, Henzing AJ; et al. (2004). "Borealin: a novel chromosomal passenger required for stability of the bipolar mitotic spindle". J. Cell Biol. 166 (2): 179–91. doi:10.1083/jcb.200404001. PMID 15249581.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Li X, Sakashita G, Matsuzaki H; et al. (2004). "Direct association with inner centromere protein (INCENP) activates the novel chromosomal passenger protein, Aurora-C". J. Biol. Chem. 279 (45): 47201–11. doi:10.1074/jbc.M403029200. PMID 15316025.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Zhu C, Bossy-Wetzel E, Jiang W (2005). "Recruitment of MKLP1 to the spindle midzone/midbody by INCENP is essential for midbody formation and completion of cytokinesis in human cells". Biochem. J. 389 (Pt 2): 373–81. doi:10.1042/BJ20050097. PMID 15796717.CS1 maint: Multiple names: authors list (link)
• Chen HL, Tang CJ, Chen CY, Tang TK (2005). "Overexpression of an Aurora-C kinase-deficient mutant disrupts the Aurora-B/INCENP complex and induces polyploidy". J. Biomed. Sci. 12 (2): 297–310. doi:10.1007/s11373-005-0980-0. PMID 15917996.CS1 maint: Multiple names: authors list (link)
• Vader G, Kauw JJ, Medema RH, Lens SM (2006). "Survivin mediates targeting of the chromosomal passenger complex to the centromere and midbody". EMBO Rep. 7 (1): 85–92. doi:10.1038/sj.embor.7400562. PMID 16239925.CS1 maint: Multiple names: authors list (link)
• Goto H, Kiyono T, Tomono Y; et al. (2006). "Complex formation of Plk1 and INCENP required for metaphase-anaphase transition". Nat. Cell Biol. 8 (2): 180–7. doi:10.1038/ncb1350. PMID 16378098.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)