IRS4

Insulin receptor substrate 4
Identifiers
Symbols	IRS4 ; IRS-4; PY160
External IDs	Template:OMIM5 Template:MGI HomoloGene: 2673
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Biological process Template:GNF GO
RNA expression pattern
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Insulin receptor substrate 4, also known as IRS4, is a human gene.

IRS4 encodes the insulin receptor substrate 4, a cytoplasmic protein that contains many potential tyrosine and serine/threonine phosphorylation sites. Tyrosine-phosphorylated IRS4 protein has been shown to associate with cytoplasmic signalling molecules that contain SH2 domains. The IRS4 protein is phosphorylated by the insulin receptor tyrosine kinase upon receptor stimulation..

Further reading

• White MF (1999). "The IRS-signalling system: a network of docking proteins that mediate insulin action". Mol. Cell. Biochem. 182 (1–2): 3–11. PMID 9609109.
• Lavan BE, Fantin VR, Chang ET; et al. (1997). "A novel 160-kDa phosphotyrosine protein in insulin-treated embryonic kidney cells is a new member of the insulin receptor substrate family". J. Biol. Chem. 272 (34): 21403–7. PMID 9261155.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Fantin VR, Sparling JD, Slot JW; et al. (1998). "Characterization of insulin receptor substrate 4 in human embryonic kidney 293 cells". J. Biol. Chem. 273 (17): 10726–32. PMID 9553137.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Koval AP, Karas M, Zick Y, LeRoith D (1998). "Interplay of the proto-oncogene proteins CrkL and CrkII in insulin-like growth factor-I receptor-mediated signal transduction". J. Biol. Chem. 273 (24): 14780–7. PMID 9614078.CS1 maint: Multiple names: authors list (link)
• Uchida T, Myers MG, White MF (2000). "IRS-4 mediates protein kinase B signaling during insulin stimulation without promoting antiapoptosis". Mol. Cell. Biol. 20 (1): 126–38. PMID 10594015.CS1 maint: Multiple names: authors list (link)
• Karas M, Koval AP, Zick Y, LeRoith D (2001). "The insulin-like growth factor I receptor-induced interaction of insulin receptor substrate-4 and Crk-II". Endocrinology. 142 (5): 1835–40. PMID 11316748.CS1 maint: Multiple names: authors list (link)
• Sano H, Liu SC, Lane WS; et al. (2002). "Insulin receptor substrate 4 associates with the protein IRAS". J. Biol. Chem. 277 (22): 19439–47. doi:10.1074/jbc.M111838200. PMID 11912194.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Krebs DL, Uren RT, Metcalf D; et al. (2002). "SOCS-6 binds to insulin receptor substrate 4, and mice lacking the SOCS-6 gene exhibit mild growth retardation". Mol. Cell. Biol. 22 (13): 4567–78. PMID 12052866.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Schreyer S, Ledwig D, Rakatzi I; et al. (2003). "Insulin receptor substrate-4 is expressed in muscle tissue without acting as a substrate for the insulin receptor". Endocrinology. 144 (4): 1211–8. PMID 12639902.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Escribano O, Fernández-Moreno MD, Zueco JA; et al. (2003). "Insulin receptor substrate-4 signaling in quiescent rat hepatocytes and in regenerating rat liver". Hepatology. 37 (6): 1461–9. doi:10.1053/jhep.2003.50245. PMID 12774026.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Yen HW, Jakimiuk AJ, Munir I, Magoffin DA (2005). "Selective alterations in insulin receptor substrates-1, -2 and -4 in theca but not granulosa cells from polycystic ovaries". Mol. Hum. Reprod. 10 (7): 473–9. doi:10.1093/molehr/gah066. PMID 15155816.CS1 maint: Multiple names: authors list (link)
• Hinsby AM, Olsen JV, Mann M (2004). "Tyrosine phosphoproteomics of fibroblast growth factor signaling: a role for insulin receptor substrate-4". J. Biol. Chem. 279 (45): 46438–47. doi:10.1074/jbc.M404537200. PMID 15316024.CS1 maint: Multiple names: authors list (link)
• Jin J, Smith FD, Stark C; et al. (2004). "Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization". Curr. Biol. 14 (16): 1436–50. doi:10.1016/j.cub.2004.07.051. PMID 15324660.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Mihindukulasuriya KA, Zhou G, Qin J, Tan TH (2004). "Protein phosphatase 4 interacts with and down-regulates insulin receptor substrate 4 following tumor necrosis factor-alpha stimulation". J. Biol. Chem. 279 (45): 46588–94. doi:10.1074/jbc.M408067200. PMID 15331607.CS1 maint: Multiple names: authors list (link)
• Qiu H, Zappacosta F, Su W; et al. (2005). "Interaction between Brk kinase and insulin receptor substrate-4". Oncogene. 24 (36): 5656–64. doi:10.1038/sj.onc.1208721. PMID 15870689.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Cuevas EP, Escribano O, Chiloeches A; et al. (2007). "Role of insulin receptor substrate-4 in IGF-I-stimulated HEPG2 proliferation". J. Hepatol. 46 (6): 1089–98. doi:10.1016/j.jhep.2007.01.031. PMID 17408801.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)