ITGA9

Integrin, alpha 9
Identifiers
Symbols	ITGA9 ; ALPHA-RLC; ITGA4L; RLC
External IDs	Template:OMIM5 Template:MGI HomoloGene: 1664
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO
RNA expression pattern
File:PBB GE ITGA9 gnf1h04097 s at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Integrin, alpha 9, also known as ITGA9, is a human gene.

This gene encodes an alpha integrin. Integrins are heterodimeric integral membrane glycoproteins composed of an alpha chain and a beta chain that mediate cell-cell and cell-matrix adhesion. The protein encoded by this gene, when bound to the beta 1 chain, forms an integrin that is a receptor for VCAM1, cytotactin and osteopontin. Expression of this gene has been found to be upregulated in small cell lung cancers.

Further reading

• Evans JP (2001). "Fertilin beta and other ADAMs as integrin ligands: insights into cell adhesion and fertilization". Bioessays. 23 (7): 628–39. doi:10.1002/bies.1088. PMID 11462216.
• Palmer EL, Rüegg C, Ferrando R; et al. (1994). "Sequence and tissue distribution of the integrin alpha 9 subunit, a novel partner of beta 1 that is widely distributed in epithelia and muscle". J. Cell Biol. 123 (5): 1289–97. PMID 8245132.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Hibi K, Yamakawa K, Ueda R; et al. (1994). "Aberrant upregulation of a novel integrin alpha subunit gene at 3p21.3 in small cell lung cancer". Oncogene. 9 (2): 611–9. PMID 8290272.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Yamakawa K, Takahashi T, Horio Y; et al. (1993). "Frequent homozygous deletions in lung cancer cell lines detected by a DNA marker located at 3p21.3-p22". Oncogene. 8 (2): 327–30. PMID 8381220.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Yokosaki Y, Monis H, Chen J, Sheppard D (1996). "Differential effects of the integrins alpha9beta1, alphavbeta3, and alphavbeta6 on cell proliferative responses to tenascin. Roles of the beta subunit extracellular and cytoplasmic domains". J. Biol. Chem. 271 (39): 24144–50. PMID 8798654.CS1 maint: Multiple names: authors list (link)
• Yokosaki Y, Matsuura N, Sasaki T; et al. (2000). "The integrin alpha(9)beta(1) binds to a novel recognition sequence (SVVYGLR) in the thrombin-cleaved amino-terminal fragment of osteopontin". J. Biol. Chem. 274 (51): 36328–34. PMID 10593924.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Young BA, Taooka Y, Liu S; et al. (2002). "The cytoplasmic domain of the integrin alpha9 subunit requires the adaptor protein paxillin to inhibit cell spreading but promotes cell migration in a paxillin-independent manner". Mol. Biol. Cell. 12 (10): 3214–25. PMID 11598204.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Eto K, Huet C, Tarui T; et al. (2002). "Functional classification of ADAMs based on a conserved motif for binding to integrin alpha 9beta 1: implications for sperm-egg binding and other cell interactions". J. Biol. Chem. 277 (20): 17804–10. doi:10.1074/jbc.M200086200. PMID 11882657.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Majumdar M, Tarui T, Shi B; et al. (2004). "Plasmin-induced migration requires signaling through protease-activated receptor 1 and integrin alpha(9)beta(1)". J. Biol. Chem. 279 (36): 37528–34. doi:10.1074/jbc.M401372200. PMID 15247268.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Chen C, Young BA, Coleman CS; et al. (2004). "Spermidine/spermine N1-acetyltransferase specifically binds to the integrin alpha9 subunit cytoplasmic domain and enhances cell migration". J. Cell Biol. 167 (1): 161–70. doi:10.1083/jcb.200312166. PMID 15479742.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Vlahakis NE, Young BA, Atakilit A, Sheppard D (2005). "The lymphangiogenic vascular endothelial growth factors VEGF-C and -D are ligands for the integrin alpha9beta1". J. Biol. Chem. 280 (6): 4544–52. doi:10.1074/jbc.M412816200. PMID 15590642.CS1 maint: Multiple names: authors list (link)
• Yokosaki Y, Tanaka K, Higashikawa F; et al. (2005). "Distinct structural requirements for binding of the integrins alphavbeta6, alphavbeta3, alphavbeta5, alpha5beta1 and alpha9beta1 to osteopontin". Matrix Biol. 24 (6): 418–27. doi:10.1016/j.matbio.2005.05.005. PMID 16005200.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gulubova M, Vlaykova T (2006). "Immunohistochemical assessment of fibronectin and tenascin and their integrin receptors alpha5beta1 and alpha9beta1 in gastric and colorectal cancers with lymph node and liver metastases". Acta Histochem. 108 (1): 25–35. doi:10.1016/j.acthis.2005.12.001. PMID 16430945.