Inosine monophosphate synthase

5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase
PDB rendering based on 1p4r.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 1p4r​, 1pkx​, 1pl0​
Identifiers
Symbols	ATIC ; AICAR; AICARFT; IMPCHASE; PURH
External IDs	Template:OMIM5 Template:MGI HomoloGene: 2983
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO
RNA expression pattern
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase, also known as ATIC and Inosine monophosphate synthase, is a human gene.

ATIC encodes an enzyme which generates inosine monophosphate from aminoimidazole carboxamide ribonucleotide.

It has two functions:

• EC 2.1.2.3 - 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase
• EC 3.5.4.10 - IMP cyclohydrolase

Further reading

• Rasmussen HH, van Damme J, Puype M; et al. (1993). "Microsequences of 145 proteins recorded in the two-dimensional gel protein database of normal human epidermal keratinocytes". Electrophoresis. 13 (12): 960–9. PMID 1286667.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Rayl EA, Moroson BA, Beardsley GP (1996). "The human purH gene product, 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase. Cloning, sequencing, expression, purification, kinetic analysis, and domain mapping". J. Biol. Chem. 271 (4): 2225–33. PMID 8567683.CS1 maint: Multiple names: authors list (link)
• Yamauchi M, Seki N, Mita K; et al. (1996). "Isolation of human purH gene expressed in the rodent transformant cells by subtractive enrichment of 3'-untranslated region of human transcript". DNA Res. 2 (6): 269–75. PMID 8867801.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Sugita T, Aya H, Ueno M; et al. (1997). "Characterization of molecularly cloned human 5-aminoimidazole-4-carboxamide ribonucleotide transformylase". J. Biochem. 122 (2): 309–13. PMID 9378707.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Beardsley GP, Rayl EA, Gunn K; et al. (1998). "Structure and functional relationships in human pur H.". Adv. Exp. Med. Biol. 431: 221–6. PMID 9598063.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Vergis JM, Bulock KG, Fleming KG, Beardsley GP (2001). "Human 5-aminoimidazole-4-carboxamide ribonucleotide transformylase/inosine 5'-monophosphate cyclohydrolase. A bifunctional protein requiring dimerization for transformylase activity but not for cyclohydrolase activity". J. Biol. Chem. 276 (11): 7727–33. doi:10.1074/jbc.M009940200. PMID 11096114.CS1 maint: Multiple names: authors list (link)
• Bulock KG, Beardsley GP, Anderson KS (2002). "The kinetic mechanism of the human bifunctional enzyme ATIC (5-amino-4-imidazolecarboxamide ribonucleotide transformylase/inosine 5'-monophosphate cyclohydrolase). A surprising lack of substrate channeling". J. Biol. Chem. 277 (25): 22168–74. doi:10.1074/jbc.M111964200. PMID 11948179.CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Cheong CG, Wolan DW, Greasley SE; et al. (2004). "Crystal structures of human bifunctional enzyme aminoimidazole-4-carboxamide ribonucleotide transformylase/IMP cyclohydrolase in complex with potent sulfonyl-containing antifolates". J. Biol. Chem. 279 (17): 18034–45. doi:10.1074/jbc.M313691200. PMID 14966129.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Marie S, Heron B, Bitoun P; et al. (2004). "AICA-ribosiduria: a novel, neurologically devastating inborn error of purine biosynthesis caused by mutation of ATIC". Am. J. Hum. Genet. 74 (6): 1276–81. doi:10.1086/421475. PMID 15114530.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Dervieux T, Furst D, Lein DO; et al. (2004). "Polyglutamation of methotrexate with common polymorphisms in reduced folate carrier, aminoimidazole carboxamide ribonucleotide transformylase, and thymidylate synthase are associated with methotrexate effects in rheumatoid arthritis". Arthritis Rheum. 50 (9): 2766–74. doi:10.1002/art.20460. PMID 15457444.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ewing RM, Chu P, Elisma F; et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3: 89. doi:10.1038/msb4100134. PMID 17353931.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)

External links

• Inosine+monophosphate+synthase at the US National Library of Medicine Medical Subject Headings (MeSH)