JAG2

Jagged 2
Identifiers
Symbols	JAG2 ; HJ2
External IDs	Template:OMIM5 Template:MGI HomoloGene: 1677
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Jagged 2, also known as JAG2, is a human gene.

The Notch signaling pathway is an intercellular signaling mechanism that is essential for proper embryonic development. Members of the Notch gene family encode transmembrane receptors that are critical for various cell fate decisions. The protein encoded by this gene is one of several ligands that activate Notch and related receptors. Two transcript variants encoding different isoforms have been found for this gene.

Further reading

• Shawber C, Boulter J, Lindsell CE, Weinmaster G (1997). "Jagged2: a serrate-like gene expressed during rat embryogenesis". Dev. Biol. 180 (1): 370–6. doi:10.1006/dbio.1996.0310. PMID 8948600.CS1 maint: Multiple names: authors list (link)
• Luo B, Aster JC, Hasserjian RP; et al. (1997). "Isolation and functional analysis of a cDNA for human Jagged2, a gene encoding a ligand for the Notch1 receptor". Mol. Cell. Biol. 17 (10): 6057–67. PMID 9315665.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Valsecchi C, Ghezzi C, Ballabio A, Rugarli EI (1998). "JAGGED2: a putative Notch ligand expressed in the apical ectodermal ridge and in sites of epithelial-mesenchymal interactions". Mech. Dev. 69 (1–2): 203–7. PMID 9486542.CS1 maint: Multiple names: authors list (link)
• Gray GE, Mann RS, Mitsiadis E; et al. (1999). "Human ligands of the Notch receptor". Am. J. Pathol. 154 (3): 785–94. PMID 10079256.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Lanford PJ, Lan Y, Jiang R; et al. (1999). "Notch signalling pathway mediates hair cell development in mammalian cochlea". Nat. Genet. 21 (3): 289–92. doi:10.1038/6804. PMID 10080181.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Felli MP, Maroder M, Mitsiadis TA; et al. (1999). "Expression pattern of notch1, 2 and 3 and Jagged1 and 2 in lymphoid and stromal thymus components: distinct ligand-receptor interactions in intrathymic T cell development". Int. Immunol. 11 (7): 1017–25. PMID 10383933.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Deng Y, Madan A, Banta AB; et al. (2000). "Characterization, chromosomal localization, and the complete 30-kb DNA sequence of the human Jagged2 (JAG2) gene". Genomics. 63 (1): 133–8. doi:10.1006/geno.1999.6045. PMID 10662552.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Tsai S, Fero J, Bartelmez S (2000). "Mouse Jagged2 is differentially expressed in hematopoietic progenitors and endothelial cells and promotes the survival and proliferation of hematopoietic progenitors by direct cell-to-cell contact". Blood. 96 (3): 950–7. PMID 10910909.CS1 maint: Multiple names: authors list (link)
• Shimizu K, Chiba S, Hosoya N; et al. (2000). "Binding of Delta1, Jagged1, and Jagged2 to Notch2 rapidly induces cleavage, nuclear translocation, and hyperphosphorylation of Notch2". Mol. Cell. Biol. 20 (18): 6913–22. PMID 10958687.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Shimizu K, Chiba S, Saito T; et al. (2000). "Physical interaction of Delta1, Jagged1, and Jagged2 with Notch1 and Notch3 receptors". Biochem. Biophys. Res. Commun. 276 (1): 385–9. doi:10.1006/bbrc.2000.3469. PMID 11006133.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Cereseto A, Tsai S (2000). "Jagged2 induces cell cycling in confluent fibroblasts susceptible to density-dependent inhibition of cell division". J. Cell. Physiol. 185 (3): 425–31. doi:10.1002/1097-4652(200012)185:3<425::AID-JCP13>3.0.CO;2-U. PMID 11056013.
• Lindner V, Booth C, Prudovsky I; et al. (2001). "Members of the Jagged/Notch gene families are expressed in injured arteries and regulate cell phenotype via alterations in cell matrix and cell-cell interaction". Am. J. Pathol. 159 (3): 875–83. PMID 11549580.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Hayashi T, Kageyama Y, Ishizaka K; et al. (2002). "Requirement of Notch 1 and its ligand jagged 2 expressions for spermatogenesis in rat and human testes". J. Androl. 22 (6): 999–1011. PMID 11700865.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ikeuchi T, Sisodia SS (2003). "The Notch ligands, Delta1 and Jagged2, are substrates for presenilin-dependent "gamma-secretase" cleavage". J. Biol. Chem. 278 (10): 7751–4. doi:10.1074/jbc.C200711200. PMID 12551931.
• Houde C, Li Y, Song L; et al. (2004). "Overexpression of the NOTCH ligand JAG2 in malignant plasma cells from multiple myeloma patients and cell lines". Blood. 104 (12): 3697–704. doi:10.1182/blood-2003-12-4114. PMID 15292061.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Lim J, Hao T, Shaw C; et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)