KIF22
| Kinesin family member 22 | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||||
| Symbols | KIF22 ; KID; KNSL4; OBP; OBP-1; OBP-2 | ||||||||||
| External IDs | Template:OMIM5 Template:MGI HomoloGene: 32011 | ||||||||||
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| RNA expression pattern | |||||||||||
| File:PBB GE KIF22 202183 s at tn.png | |||||||||||
| File:PBB GE KIF22 216969 s at tn.png | |||||||||||
| More reference expression data | |||||||||||
| Orthologs | |||||||||||
| Template:GNF Ortholog box | |||||||||||
| Species | Human | Mouse | |||||||||
| Entrez | n/a | n/a | |||||||||
| Ensembl | n/a | n/a | |||||||||
| UniProt | n/a | n/a | |||||||||
| RefSeq (mRNA) | n/a | n/a | |||||||||
| RefSeq (protein) | n/a | n/a | |||||||||
| Location (UCSC) | n/a | n/a | |||||||||
| PubMed search | n/a | n/a | |||||||||
Kinesin family member 22, also known as KIF22, is a human gene.[1]
The protein encoded by this gene is a member of kinesin-like protein family. This family of proteins are microtubule-dependent molecular motors that transport organelles within cells and move chromosomes during cell division. The C-terminal half of this protein has been shown to bind DNA. Studies with the Xenopus homolog suggests its essential role in metaphase chromosome alignment and maintenance.[1]
References
Further reading
- Miki H, Setou M, Kaneshiro K, Hirokawa N (2001). "All kinesin superfamily protein, KIF, genes in mouse and human". Proc. Natl. Acad. Sci. U.S.A. 98 (13): 7004–11. doi:10.1073/pnas.111145398. PMID 11416179.
- Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. PMID 8125298.
- Zhang S, Nonoyama M (1994). "The cellular proteins that bind specifically to the Epstein-Barr virus origin of plasmid DNA replication belong to a gene family". Proc. Natl. Acad. Sci. U.S.A. 91 (7): 2843–7. PMID 8146198.
- Tokai N, Fujimoto-Nishiyama A, Toyoshima Y; et al. (1996). "Kid, a novel kinesin-like DNA binding protein, is localized to chromosomes and the mitotic spindle". EMBO J. 15 (3): 457–67. PMID 8599929.
- Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K; et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. PMID 9373149.
- Song J, Murakami H, Tsutsui H; et al. (1998). "Genomic organization and expression of a human gene for Myc-associated zinc finger protein (MAZ)". J. Biol. Chem. 273 (32): 20603–14. PMID 9685418.
- Song J, Murakami H, Yang ZQ; et al. (1998). "Human genes for KNSL4 and MAZ are located close to one another on chromosome 16p11.2". Genomics. 52 (3): 374–7. doi:10.1006/geno.1998.5452. PMID 9790757.
- Loftus BJ, Kim UJ, Sneddon VP; et al. (1999). "Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q". Genomics. 60 (3): 295–308. doi:10.1006/geno.1999.5927. PMID 10493829.
- Funabiki H, Murray AW (2000). "The Xenopus chromokinesin Xkid is essential for metaphase chromosome alignment and must be degraded to allow anaphase chromosome movement". Cell. 102 (4): 411–24. PMID 10966104.
- Antonio C, Ferby I, Wilhelm H; et al. (2000). "Xkid, a chromokinesin required for chromosome alignment on the metaphase plate". Cell. 102 (4): 425–35. PMID 10966105.
- Germani A, Bruzzoni-Giovanelli H, Fellous A; et al. (2001). "SIAH-1 interacts with alpha-tubulin and degrades the kinesin Kid by the proteasome pathway during mitosis". Oncogene. 19 (52): 5997–6006. doi:10.1038/sj.onc.1204002. PMID 11146551.
- Levesque AA, Compton DA (2001). "The chromokinesin Kid is necessary for chromosome arm orientation and oscillation, but not congression, on mitotic spindles". J. Cell Biol. 154 (6): 1135–46. doi:10.1083/jcb.200106093. PMID 11564754.
- Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
- Yajima J, Edamatsu M, Watai-Nishii J; et al. (2003). "The human chromokinesin Kid is a plus end-directed microtubule-based motor". EMBO J. 22 (5): 1067–74. doi:10.1093/emboj/cdg102. PMID 12606572.
- Shiroguchi K, Ohsugi M, Edamatsu M; et al. (2003). "The second microtubule-binding site of monomeric kid enhances the microtubule affinity". J. Biol. Chem. 278 (25): 22460–5. doi:10.1074/jbc.M212274200. PMID 12692123.
- Ohsugi M, Tokai-Nishizumi N, Shiroguchi K; et al. (2003). "Cdc2-mediated phosphorylation of Kid controls its distribution to spindle and chromosomes". EMBO J. 22 (9): 2091–103. doi:10.1093/emboj/cdg208. PMID 12727876.
- Venkatesh LK, Gettemeier T, Chinnadurai G (2003). "A nuclear kinesin-like protein interacts with and stimulates the activity of the leucine-rich nuclear export signal of the human immunodeficiency virus type 1 rev protein". J. Virol. 77 (13): 7236–43. PMID 12805422.
- Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
- Tokai-Nishizumi N, Ohsugi M, Suzuki E, Yamamoto T (2006). "The chromokinesin Kid is required for maintenance of proper metaphase spindle size". Mol. Biol. Cell. 16 (11): 5455–63. doi:10.1091/mbc.E05-03-0244. PMID 16176979.
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