KLC3

Kinesin light chain 3
Identifiers
Symbols	KLC3 ; KLC2; KLC2L; KLCt; KNS2B
External IDs	Template:OMIM5 Template:MGI HomoloGene: 14899
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Kinesin light chain 3, also known as KLC3, is a human gene.

This gene encodes a member of the kinesin light chain gene family. Kinesins are molecular motors involved in the transport of cargo along microtubules, and are composed of two kinesin heavy chain (KHC) and two kinesin light chain (KLC) molecules. KLCs are thought to typically be involved in binding cargo and regulating kinesin activity. In the rat, a protein similar to this gene product is expressed in post-meiotic spermatids, where it associates with structural components of sperm tails and mitochondria.

Further reading

• Ewing RM, Chu P, Elisma F; et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3: 89. doi:10.1038/msb4100134. PMID 17353931.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Zhang Y, Oko R, van der Hoorn FA (2004). "Rat kinesin light chain 3 associates with spermatid mitochondria". Dev. Biol. 275 (1): 23–33. doi:10.1016/j.ydbio.2004.07.014. PMID 15464570.CS1 maint: Multiple names: authors list (link)
• Jin J, Smith FD, Stark C; et al. (2004). "Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization". Curr. Biol. 14 (16): 1436–50. doi:10.1016/j.cub.2004.07.051. PMID 15324660.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Bhullar B, Zhang Y, Junco A; et al. (2003). "Association of kinesin light chain with outer dense fibers in a microtubule-independent fashion". J. Biol. Chem. 278 (18): 16159–68. doi:10.1074/jbc.M213126200. PMID 12594206.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Yang J, Liu X, Yue G; et al. (2002). "Rootletin, a novel coiled-coil protein, is a structural component of the ciliary rootlet". J. Cell Biol. 159 (3): 431–40. doi:10.1083/jcb.200207153. PMID 12427867.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ichimura T, Wakamiya-Tsuruta A, Itagaki C; et al. (2002). "Phosphorylation-dependent interaction of kinesin light chain 2 and the 14-3-3 protein". Biochemistry. 41 (17): 5566–72. PMID 11969417.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Junco A, Bhullar B, Tarnasky HA, van der Hoorn FA (2001). "Kinesin light-chain KLC3 expression in testis is restricted to spermatids". Biol. Reprod. 64 (5): 1320–30. PMID 11319135.CS1 maint: Multiple names: authors list (link)
• Rahman A, Kamal A, Roberts EA, Goldstein LS (1999). "Defective kinesin heavy chain behavior in mouse kinesin light chain mutants". J. Cell Biol. 146 (6): 1277–88. PMID 10491391.CS1 maint: Multiple names: authors list (link)
• Rahman A, Friedman DS, Goldstein LS (1998). "Two kinesin light chain genes in mice. Identification and characterization of the encoded proteins". J. Biol. Chem. 273 (25): 15395–403. PMID 9624122.CS1 maint: Multiple names: authors list (link)
• Lamerdin JE, Stilwagen SA, Ramirez MH; et al. (1996). "Sequence analysis of the ERCC2 gene regions in human, mouse, and hamster reveals three linked genes". Genomics. 34 (3): 399–409. doi:10.1006/geno.1996.0303. PMID 8786141.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)