KLK8

Kallikrein-related peptidase 8
Identifiers
Symbols	KLK8 ; NP; HNP; NRPN; PRSS19; TADG14
External IDs	Template:OMIM5 Template:MGI HomoloGene: 21410
Gene ontology Molecular function Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Kallikrein-related peptidase 8, also known as KLK8, is a human gene.

Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Alternate splicing of this gene results in four transcript variants encoding four different isoforms. The isoforms exhibit distinct patterns of expression that suggest roles in brain plasticity and ovarian cancer.

Further reading

• Yoshida S, Taniguchi M, Hirata A, Shiosaka S (1998). "Sequence analysis and expression of human neuropsin cDNA and gene". Gene. 213 (1–2): 9–16. PMID 9714609.CS1 maint: Multiple names: authors list (link)
• Mitsui S, Tsuruoka N, Yamashiro K; et al. (1999). "A novel form of human neuropsin, a brain-related serine protease, is generated by alternative splicing and is expressed preferentially in human adult brain". Eur. J. Biochem. 260 (3): 627–34. PMID 10102990.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Underwood LJ, Tanimoto H, Wang Y; et al. (1999). "Cloning of tumor-associated differentially expressed gene-14, a novel serine protease overexpressed by ovarian carcinoma". Cancer Res. 59 (17): 4435–9. PMID 10485494.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Harvey TJ, Hooper JD, Myers SA; et al. (2001). "Tissue-specific expression patterns and fine mapping of the human kallikrein (KLK) locus on proximal 19q13.4". J. Biol. Chem. 275 (48): 37397–406. doi:10.1074/jbc.M004525200. PMID 10969073.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gan L, Lee I, Smith R; et al. (2001). "Sequencing and expression analysis of the serine protease gene cluster located in chromosome 19q13 region". Gene. 257 (1): 119–30. PMID 11054574.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Magklara A, Scorilas A, Katsaros D; et al. (2001). "The human KLK8 (neuropsin/ovasin) gene: identification of two novel splice variants and its prognostic value in ovarian cancer". Clin. Cancer Res. 7 (4): 806–11. PMID 11309326.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Clark HF, Gurney AL, Abaya E; et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMID 12975309.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Cané S, Bignotti E, Bellone S; et al. (2004). "The novel serine protease tumor-associated differentially expressed gene-14 (KLK8/Neuropsin/Ovasin) is highly overexpressed in cervical cancer". Am. J. Obstet. Gynecol. 190 (1): 60–6. doi:10.1016/j.ajog.2003.07.020. PMID 14749636.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Grimwood J, Gordon LA, Olsen A; et al. (2004). "The DNA sequence and biology of human chromosome 19". Nature. 428 (6982): 529–35. doi:10.1038/nature02399. PMID 15057824.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Shigemasa K, Tian X, Gu L; et al. (2004). "Human kallikrein 8 (hK8/TADG-14) expression is associated with an early clinical stage and favorable prognosis in ovarian cancer". Oncol. Rep. 11 (6): 1153–9. PMID 15138549.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Li Y, Qian YP, Yu XJ; et al. (2005). "Recent origin of a hominoid-specific splice form of neuropsin, a gene involved in learning and memory". Mol. Biol. Evol. 21 (11): 2111–5. doi:10.1093/molbev/msh220. PMID 15282331.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Rajapakse S, Ogiwara K, Takano N; et al. (2006). "Biochemical characterization of human kallikrein 8 and its possible involvement in the degradation of extracellular matrix proteins". FEBS Lett. 579 (30): 6879–84. doi:10.1016/j.febslet.2005.11.039. PMID 16337200.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• "Proceedings of the 1st International Symposium on Kallikreins, Lausanne, Switzerland, September 1-3 , 2005". Biol. Chem. 387 (6): 635–824. 2006. doi:10.1515/BC.2006.081. PMID 16800723.
• Lundwall A, Band V, Blaber M; et al. (2006). "A comprehensive nomenclature for serine proteases with homology to tissue kallikreins". Biol. Chem. 387 (6): 637–41. doi:10.1515/BC.2006.082. PMID 16800724.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kishi T, Cloutier SM, Kündig C; et al. (2006). "Activation and enzymatic characterization of recombinant human kallikrein 8". Biol. Chem. 387 (6): 723–31. doi:10.1515/BC.2006.091. PMID 16800733.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Sher YP, Chou CC, Chou RH; et al. (2007). "Human kallikrein 8 protease confers a favorable clinical outcome in non-small cell lung cancer by suppressing tumor cell invasiveness". Cancer Res. 66 (24): 11763–70. doi:10.1158/0008-5472.CAN-06-3165. PMID 17178872.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Lu ZX, Peng J, Su B (2007). "A human-specific mutation leads to the origin of a novel splice form of neuropsin (KLK8), a gene involved in learning and memory". Hum. Mutat. 28 (10): 978–84. doi:10.1002/humu.20547. PMID 17487847.CS1 maint: Multiple names: authors list (link)