KLRG1
| Killer cell lectin-like receptor subfamily G, member 1 | |||||||||||
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| Identifiers | |||||||||||
| Symbols | KLRG1 ; 2F1; CLEC15A; MAFA; MAFA-2F1; MAFA-L; MGC13600 | ||||||||||
| External IDs | Template:OMIM5 Template:MGI HomoloGene: 4244 | ||||||||||
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| RNA expression pattern | |||||||||||
| File:PBB GE KLRG1 210288 at tn.png | |||||||||||
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| Template:GNF Ortholog box | |||||||||||
| Species | Human | Mouse | |||||||||
| Entrez | n/a | n/a | |||||||||
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| RefSeq (mRNA) | n/a | n/a | |||||||||
| RefSeq (protein) | n/a | n/a | |||||||||
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Killer cell lectin-like receptor subfamily G, member 1, also known as KLRG1, is a human gene.[1]
Natural killer (NK) cells are lymphocytes that can mediate lysis of certain tumor cells and virus-infected cells without previous activation. They can also regulate specific humoral and cell-mediated immunity. The protein encoded by this gene belongs to the killer cell lectin-like receptor (KLR) family, which is a group of transmembrane proteins preferentially expressed in NK cells. Studies in mice suggested that the expression of this gene may be regulated by MHC class I molecules. Alternatively spliced transcript variants have been reported, but their full-length natures have not yet been determined.[1]
References
Further reading
- Ortega E, Schneider H, Pecht I (1991). "Possible interactions between the Fc epsilon receptor and a novel mast cell function-associated antigen". Int. Immunol. 3 (4): 333–42. PMID 1831652.
- Lamers MB, Lamont AG, Williams DH (1998). "Human MAFA has alternatively spliced variants". Biochim. Biophys. Acta. 1399 (2–3): 209–12. PMID 9765598.
- Butcher S, Arney KL, Cook GP (1998). "MAFA-L, an ITIM-containing receptor encoded by the human NK cell gene complex and expressed by basophils and NK cells". Eur. J. Immunol. 28 (11): 3755–62. PMID 9842918.
- Hanke T, Corral L, Vance RE, Raulet DH (1999). "2F1 antigen, the mouse homolog of the rat "mast cell function-associated antigen", is a lectin-like type II transmembrane receptor expressed by natural killer cells". Eur. J. Immunol. 28 (12): 4409–17. PMID 9862378.
- Voehringer D, Koschella M, Pircher H (2003). "Lack of proliferative capacity of human effector and memory T cells expressing killer cell lectinlike receptor G1 (KLRG1)". Blood. 100 (10): 3698–702. doi:10.1182/blood-2002-02-0657. PMID 12393723.
- Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
- Matsuoka TA, Artner I, Henderson E; et al. (2004). "The MafA transcription factor appears to be responsible for tissue-specific expression of insulin". Proc. Natl. Acad. Sci. U.S.A. 101 (9): 2930–3. doi:10.1073/pnas.0306233101. PMID 14973194.
- Marcolino I, Przybylski GK, Koschella M; et al. (2004). "Frequent expression of the natural killer cell receptor KLRG1 in human cord blood T cells: correlation with replicative history". Eur. J. Immunol. 34 (10): 2672–80. doi:10.1002/eji.200425282. PMID 15368283.
- Ibegbu CC, Xu YX, Harris W; et al. (2005). "Expression of killer cell lectin-like receptor G1 on antigen-specific human CD8+ T lymphocytes during active, latent, and resolved infection and its relation with CD57". J. Immunol. 174 (10): 6088–94. PMID 15879103.
- Thimme R, Appay V, Koschella M; et al. (2005). "Increased expression of the NK cell receptor KLRG1 by virus-specific CD8 T cells during persistent antigen stimulation". J. Virol. 79 (18): 12112–6. doi:10.1128/JVI.79.18.12112-12116.2005. PMID 16140789.
- Rual JF, Venkatesan K, Hao T; et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
- Ito M, Maruyama T, Saito N; et al. (2006). "Killer cell lectin-like receptor G1 binds three members of the classical cadherin family to inhibit NK cell cytotoxicity". J. Exp. Med. 203 (2): 289–95. doi:10.1084/jem.20051986. PMID 16461340.
- Bengsch B, Spangenberg HC, Kersting N; et al. (2007). "Analysis of CD127 and KLRG1 expression on hepatitis C virus-specific CD8+ T cells reveals the existence of different memory T-cell subsets in the peripheral blood and liver". J. Virol. 81 (2): 945–53. doi:10.1128/JVI.01354-06. PMID 17079288.
- Schwartzkopff S, Gründemann C, Schweier O; et al. (2007). "Tumor-associated E-cadherin mutations affect binding to the killer cell lectin-like receptor G1 in humans". J. Immunol. 179 (2): 1022–9. PMID 17617594.
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