LECT2

Leukocyte cell-derived chemotaxin 2
Identifiers
Symbols	LECT2 ; MGC126628; chm-II; chm2
External IDs	Template:OMIM5 Template:MGI HomoloGene: 1730
Gene ontology Molecular function Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
File:PBB GE LECT2 207409 at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Leukocyte cell-derived chemotaxin 2, also known as LECT2, is a human gene.

This gene encodes a secreted, 16 kDa protein that acts as a chemotactic factor to neutrophils and stimulates the growth of chondrocytes and osteoblasts. This protein has high sequence similarity to the chondromodulin repeat regions of the chicken myb-induced myeloid 1 protein. A polymorphism in this gene may be associated with rheumatoid arthritis.

Further reading

• Yamagoe S, Yamakawa Y, Matsuo Y; et al. (1997). "Purification and primary amino acid sequence of a novel neutrophil chemotactic factor LECT2". Immunol. Lett. 52 (1): 9–13. PMID 8877413.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Yamagoe S, Akasaka T, Uchida T; et al. (1997). "Expression of a neutrophil chemotactic protein LECT2 in human hepatocytes revealed by immunochemical studies using polyclonal and monoclonal antibodies to a recombinant LECT2". Biochem. Biophys. Res. Commun. 237 (1): 116–20. doi:10.1006/bbrc.1997.7095. PMID 9266841.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Yamagoe S, Mizuno S, Suzuki K (1998). "Molecular cloning of human and bovine LECT2 having a neutrophil chemotactic activity and its specific expression in the liver". Biochim. Biophys. Acta. 1396 (1): 105–13. PMID 9524238.CS1 maint: Multiple names: authors list (link)
• Yamagoe S, Kameoka Y, Hashimoto K; et al. (1998). "Molecular cloning, structural characterization, and chromosomal mapping of the human LECT2 gene". Genomics. 48 (3): 324–9. doi:10.1006/geno.1997.5198. PMID 9545637.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Nagai H, Hamada T, Uchida T; et al. (1999). "Systemic expression of a newly recognized protein, LECT2, in the human body". Pathol. Int. 48 (11): 882–6. PMID 9832057.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kameoka Y, Yamagoe S, Hatano Y; et al. (2000). "Val58Ile polymorphism of the neutrophil chemoattractant LECT2 and rheumatoid arthritis in the Japanese population". Arthritis Rheum. 43 (6): 1419–20. doi:10.1002/1529-0131(200006)43:6<1419::AID-ANR28>3.0.CO;2-I. PMID 10857804.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Xu XR, Huang J, Xu ZG; et al. (2002). "Insight into hepatocellular carcinogenesis at transcriptome level by comparing gene expression profiles of hepatocellular carcinoma with those of corresponding noncancerous liver". Proc. Natl. Acad. Sci. U.S.A. 98 (26): 15089–94. doi:10.1073/pnas.241522398. PMID 11752456.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ovejero C, Cavard C, Périanin A; et al. (2004). "Identification of the leukocyte cell-derived chemotaxin 2 as a direct target gene of beta-catenin in the liver". Hepatology. 40 (1): 167–76. doi:10.1002/hep.20286. PMID 15239100.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ito M, Nagata K, Yumoto F; et al. (2005). "1H, 13C, 15N resonance assignments of the cytokine LECT2". J. Biomol. NMR. 29 (4): 543–4. doi:10.1023/B:JNMR.0000034343.48628.f6. PMID 15243190.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Schmutz J, Martin J, Terry A; et al. (2004). "The DNA sequence and comparative analysis of human chromosome 5". Nature. 431 (7006): 268–74. doi:10.1038/nature02919. PMID 15372022.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Sato Y, Watanabe H, Kameyama H; et al. (2005). "Changes in serum LECT 2 levels during the early period of liver regeneration after adult living related donor liver transplantation". Transplant. Proc. 36 (8): 2357–8. doi:10.1016/j.transproceed.2004.07.006. PMID 15561248.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Sato Y, Watanabe H, Kameyama H; et al. (2005). "Serum LECT2 level as a prognostic indicator in acute liver failure". Transplant. Proc. 36 (8): 2359–61. doi:10.1016/j.transproceed.2004.07.007. PMID 15561249.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)