LGALS2
Lectin, galactoside-binding, soluble, 2 | |||||||||||||
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File:PBB Protein LGALS2 image.jpg PDB rendering based on 1hlc. | |||||||||||||
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Identifiers | |||||||||||||
Symbols | LGALS2 ; HL14; MGC75071 | ||||||||||||
External IDs | Template:OMIM5 Template:MGI HomoloGene: 4741 | ||||||||||||
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RNA expression pattern | |||||||||||||
File:PBB GE LGALS2 208450 at tn.png | |||||||||||||
More reference expression data | |||||||||||||
Orthologs | |||||||||||||
Template:GNF Ortholog box | |||||||||||||
Species | Human | Mouse | |||||||||||
Entrez | n/a | n/a | |||||||||||
Ensembl | n/a | n/a | |||||||||||
UniProt | n/a | n/a | |||||||||||
RefSeq (mRNA) | n/a | n/a | |||||||||||
RefSeq (protein) | n/a | n/a | |||||||||||
Location (UCSC) | n/a | n/a | |||||||||||
PubMed search | n/a | n/a |
Lectin, galactoside-binding, soluble, 2, also known as LGALS2, is a human gene.[1]
The protein encoded by this gene is a soluble beta-galactoside binding lectin. The encoded protein is found as a homodimer and can bind to lymphotoxin-alpha. A single nucleotide polymorphism in an intron of this gene can alter the transcriptional level of the protein, with a resultant increased risk of myocardial infarction.[1]
References
Further reading
- Gitt MA, Massa SM, Leffler H, Barondes SH (1992). "Isolation and expression of a gene encoding L-14-II, a new human soluble lactose-binding lectin". J. Biol. Chem. 267 (15): 10601–6. PMID 1375225.
- Gitt MA, Barondes SH (1991). "Genomic sequence and organization of two members of a human lectin gene family". Biochemistry. 30 (1): 82–9. PMID 1988031.
- Gitt MA, Barondes SH (1986). "Evidence that a human soluble beta-galactoside-binding lectin is encoded by a family of genes". Proc. Natl. Acad. Sci. U.S.A. 83 (20): 7603–7. PMID 3020551.
- Lobsanov YD, Gitt MA, Leffler H; et al. (1994). "X-ray crystal structure of the human dimeric S-Lac lectin, L-14-II, in complex with lactose at 2.9-A resolution". J. Biol. Chem. 268 (36): 27034–8. PMID 8262940.
- Lobsanov YD, Gitt MA, Leffler H; et al. (1993). "Crystallization and preliminary X-ray diffraction analysis of the human dimeric S-Lac lectin (L-14-II)". J. Mol. Biol. 233 (3): 553–5. doi:10.1006/jmbi.1993.1533. PMID 8411163.
- Mehrabian M, Gitt MA, Sparkes RS; et al. (1993). "Two members of the S-lac lectin gene family, LGALS1 and LGALS2, reside in close proximity on human chromosome 22q12-q13". Genomics. 15 (2): 418–20. doi:10.1006/geno.1993.1078. PMID 8449510.
- Dunham I, Shimizu N, Roe BA; et al. (1999). "The DNA sequence of human chromosome 22". Nature. 402 (6761): 489–95. doi:10.1038/990031. PMID 10591208.
- Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
- Ozaki K, Inoue K, Sato H; et al. (2004). "Functional variation in LGALS2 confers risk of myocardial infarction and regulates lymphotoxin-alpha secretion in vitro". Nature. 429 (6987): 72–5. doi:10.1038/nature02502. PMID 15129282.
- Sturm A, Lensch M, André S; et al. (2004). "Human galectin-2: novel inducer of T cell apoptosis with distinct profile of caspase activation". J. Immunol. 173 (6): 3825–37. PMID 15356130.
- Collins JE, Wright CL, Edwards CA; et al. (2005). "A genome annotation-driven approach to cloning the human ORFeome". Genome Biol. 5 (10): R84. doi:10.1186/gb-2004-5-10-r84. PMID 15461802.
- Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
- Christensen MB, Lawlor DA, Gaunt TR; et al. (2006). "Genotype of galectin 2 (LGALS2) is associated with insulin-glucose profile in the British Women's Heart and Health Study". Diabetologia. 49 (4): 673–7. doi:10.1007/s00125-006-0145-3. PMID 16468038.
- Stowell SR, Karmakar S, Stowell CJ; et al. (2007). "Human galectin-1, -2, and -4 induce surface exposure of phosphatidylserine in activated human neutrophils but not in activated T cells". Blood. 109 (1): 219–27. doi:10.1182/blood-2006-03-007153. PMID 16940423.
- Mangino M, Braund P, Singh R; et al. (2007). "LGALS2 functional variant rs7291467 is not associated with susceptibility to myocardial infarction in Caucasians". Atherosclerosis. 194 (1): 112–5. doi:10.1016/j.atherosclerosis.2006.10.004. PMID 17098239.
- Kimura A, Takahashi M, Choi BY; et al. (2007). "Lack of association between LTA and LGALS2 polymorphisms and myocardial infarction in Japanese and Korean populations". Tissue Antigens. 69 (3): 265–9. doi:10.1111/j.1399-0039.2006.00798.x. PMID 17493152.
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