LGI1

Leucine-rich, glioma inactivated 1
Identifiers
Symbols	LGI1 ; EPT; ETL1; IB1099
External IDs	Template:OMIM5 Template:MGI HomoloGene: 3737
Gene ontology Molecular function Template:GNF GO Biological process Template:GNF GO Template:GNF GO
RNA expression pattern
File:PBB GE LGI1 206349 at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Leucine-rich, glioma inactivated 1, also known as LGI1, is a human gene. It may be a metastasis suppressor.

The leucine-rich glioma inactivated -1 gene is rearranged as a result of translocations in glioblastoma cell lines. The protein contains a hydrophobic segment representing a putative transmembrane domain with the amino terminus located outside the cell. It also contains leucine-rich repeats with conserved cysteine-rich flanking sequences. This gene is predominantly expressed in neural tissues and its expression is reduced in low grade brain tumors and significantly reduced or absent in malignant gliomas.

Further reading

• Staub E, Pérez-Tur J, Siebert R; et al. (2002). "The novel EPTP repeat defines a superfamily of proteins implicated in epileptic disorders". Trends Biochem. Sci. 27 (9): 441–4. PMID 12217514.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gu W, Brodtkorb E, Piepoli T; et al. (2005). "LGI1: a gene involved in epileptogenesis and glioma progression?". Neurogenetics. 6 (2): 59–66. doi:10.1007/s10048-005-0216-5. PMID 15827762.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ottman R, Risch N, Hauser WA; et al. (1995). "Localization of a gene for partial epilepsy to chromosome 10q". Nat. Genet. 10 (1): 56–60. doi:10.1038/ng0595-56. PMID 7647791.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Chernova OB, Somerville RP, Cowell JK (1999). "A novel gene, LGI1, from 10q24 is rearranged and downregulated in malignant brain tumors". Oncogene. 17 (22): 2873–81. doi:10.1038/sj.onc.1202481. PMID 9879993.CS1 maint: Multiple names: authors list (link)
• Kalachikov S, Evgrafov O, Ross B; et al. (2002). "Mutations in LGI1 cause autosomal-dominant partial epilepsy with auditory features". Nat. Genet. 30 (3): 335–41. doi:10.1038/ng832. PMID 11810107.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Morante-Redolat JM, Gorostidi-Pagola A, Piquer-Sirerol S; et al. (2002). "Mutations in the LGI1/Epitempin gene on 10q24 cause autosomal dominant lateral temporal epilepsy". Hum. Mol. Genet. 11 (9): 1119–28. PMID 11978770.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Scheel H, Tomiuk S, Hofmann K (2003). "A common protein interaction domain links two recently identified epilepsy genes". Hum. Mol. Genet. 11 (15): 1757–62. PMID 12095917.CS1 maint: Multiple names: authors list (link)
• Gu W, Brodtkorb E, Steinlein OK (2002). "LGI1 is mutated in familial temporal lobe epilepsy characterized by aphasic seizures". Ann. Neurol. 52 (3): 364–7. doi:10.1002/ana.10280. PMID 12205652.CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Pizzuti A, Flex E, Di Bonaventura C; et al. (2003). "Epilepsy with auditory features: an LGI1 gene mutation suggests a loss-of-function mechanism". Ann. Neurol. 53 (3): 396–9. doi:10.1002/ana.10492. PMID 12601709.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Fertig E, Lincoln A, Martinuzzi A; et al. (2004). "Novel LGI1 mutation in a family with autosomal dominant partial epilepsy with auditory features". Neurology. 60 (10): 1687–90. PMID 12771268.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kunapuli P, Chitta KS, Cowell JK (2003). "Suppression of the cell proliferation and invasion phenotypes in glioma cells by the LGI1 gene". Oncogene. 22 (26): 3985–91. doi:10.1038/sj.onc.1206584. PMID 12821932.CS1 maint: Multiple names: authors list (link)
• Clark HF, Gurney AL, Abaya E; et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMID 12975309.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Hedera P, Abou-Khalil B, Crunk AE; et al. (2004). "Autosomal dominant lateral temporal epilepsy: two families with novel mutations in the LGI1 gene". Epilepsia. 45 (3): 218–22. PMID 15009222.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kunapuli P, Kasyapa CS, Hawthorn L, Cowell JK (2004). "LGI1, a putative tumor metastasis suppressor gene, controls in vitro invasiveness and expression of matrix metalloproteinases in glioma cells through the ERK1/2 pathway". J. Biol. Chem. 279 (22): 23151–7. doi:10.1074/jbc. M314192200 . PMID 15047712.CS1 maint: Multiple names: authors list (link)
• Berkovic SF, Izzillo P, McMahon JM; et al. (2004). "LGI1 mutations in temporal lobe epilepsies". Neurology. 62 (7): 1115–9. PMID 15079010.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ottman R, Winawer MR, Kalachikov S; et al. (2004). "LGI1 mutations in autosomal dominant partial epilepsy with auditory features". Neurology. 62 (7): 1120–6. PMID 15079011.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Deloukas P, Earthrowl ME, Grafham DV; et al. (2004). "The DNA sequence and comparative analysis of human chromosome 10". Nature. 429 (6990): 375–81. doi:10.1038/nature02462. PMID 15164054.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Bisulli F, Tinuper P, Scudellaro E; et al. (2004). "A de novo LGI1 mutation in sporadic partial epilepsy with auditory features". Ann. Neurol. 56 (3): 455–6. doi:10.1002/ana.20218. PMID 15349881.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)